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Ketamine has 'fast-acting benefits' for depression

bbc.co.uk

181–190 of 215 posts

Re: Ketamine has 'fast-acting benefits' for depression

#181
post #92

Earlier quoted context omitted.

Do you think something like "FDA-approval of Ketamine" could be successfully crowdfunded?

It's happened with MDMA via maps.org Why not? Probably need about $25M - $50M Also Ketamine seems to be pallative vs. a cure, if I'm not mistaken.

I'd probably run a "crowdfunding" round involving people at the level of billionaire - Bill Gates, Peter Thiel, Bezos, etc.

Get 50 of those to each chip in $1 mill - it's pocket-change to them.

Re: Ketamine has 'fast-acting benefits' for depression

#182
post #88

Earlier quoted context omitted.

Ketamine isn't a pain reliever. It's a dissociative hallucinogen. It works by disconnecting you from sensory input and putting you in something like a lucid dream.

This isn't true. Ketamine infusions are also administered to patients with chronic pain.

That it’s given for pain does not make it anything like what people think of as a pain reliever. It’s nothing like Tylenol, ibuprofen, or opiates.

Re: Ketamine has 'fast-acting benefits' for depression

#183
post #62

Earlier quoted context omitted.

Doesn't ketamine stimulate growth in the same areas of the brain that exercise does, and does therapy prescribe routine daily exercise? I can imagine there being a great short term benefit to ketamine, as people who are severely depressed can't exercise due to the depression. Has there been any mention switching from ketamine to daily exercise, or doing both?

How often did you have depression? Especially major depressive episodes where you have trouble to even motivate yourself to move out of the bed or do ANYTHING but just "exist" and even that seems hard? If the answer is zero (which I think it is) do those who have it a favor and shut up. Depression is hard enough without "you just have to exercise, huahua" comments.

When studies seem to suggest exercise helps, its pretty dangerous to shout down comments like this. Especially when you're completely misrepresenting the question.

Re: Ketamine has 'fast-acting benefits' for depression

#184

Earlier quoted context omitted.

Yeah. I feel pretty lonely here... :'(

Anarcho-capitalism largely depends on a belief that human nature is essentially good, and prone to spontaneous cooperation. It is also heavily dependent on reputation, which scales poorly, or on trustless technologies, which aren't yet mature. I'm still anarchist in 2018, but I haven't been anywhere near the an-cap territory of it since around 2006. Sticking to a political dogma out in the libertarian hinterlands is…

[dead]

Re: Ketamine has 'fast-acting benefits' for depression

#185
post #7

My girlfriend receives ketamine treatment for her depression, so I’ve the results first hand. It’s truly astounding. She’s seen more improvement from the ketamine than from a decade of psychotherapy and traditional psychopharmacology. The only downside is the cost (it’s not covered by insurance) and the potential that there are long term side effects that have yet to be discovered. We pay $375 for a 40-minute infusio…

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Re: Ketamine has 'fast-acting benefits' for depression

#186
post #14
post #7

My girlfriend receives ketamine treatment for her depression, so I’ve the results first hand. It’s truly astounding. She’s seen more improvement from the ketamine than from a decade of psychotherapy and traditional psychopharmacology. The only downside is the cost (it’s not covered by insurance) and the potential that there are long term side effects that have yet to be discovered. We pay $375 for a 40-minute infusio…

Can confirm. I’m in a similar boat. Some other tidbits of information: - only thing that seemed to work even after TMS and other treatments. - New pathways (SF and San Mateo locations) is really good. - more and more treatment places opening up in different cities etc. - uber assist or drive the patient home (full lucidity afterwards but you don’t want to drive). - long-term benefits aren’t apparent after the first t…

Thanks for the info, do you know if they allow people to come in on their own? I don't really want to try to get my doctor to refer me.

Re: Ketamine has 'fast-acting benefits' for depression

#188
post #182

Earlier quoted context omitted.

This isn't true. Ketamine infusions are also administered to patients with chronic pain.

That it’s given for pain does not make it anything like what people think of as a pain reliever. It’s nothing like Tylenol, ibuprofen, or opiates.

It makes it a pain reliever.

Re: Ketamine has 'fast-acting benefits' for depression

#189
post #155

Earlier quoted context omitted.

counter anecdote i know massive amounts of people who have taken psychedelics that are depressed. similarly for ketamine.

Without specifying the relative proportion of those who went up, in your experience, along with the massive amount of people who went down, your counter anecdote is weakly armed.

I think either case is weak. Parroting Leary here seems appropriate - set and setting are just as important as dosage when it comes to these substances.

Re: Ketamine has 'fast-acting benefits' for depression

#190

I've posted this in other ketamine news stories before, but I'm offering it as a firsthand testimonial here. Ketamine was both the best and most depressing depression treatment option I've ever tried. Within a couple of weeks after having had the initial round of six treatments in two weeks, I was the most functional and productive human being I've _ever_ been - things that used to be impossible or utterly agonizing…

This easily explained: Ketamine seems to repair some kind of cell damage, thereby increasing neural plasticity.

That is a huge asset, but long endured depressions leave many unhealthy neural circuits over the years. These have be unlearned one by one, which takes time.

Ketamine increases freedom of thought and emotion, but you still need a goal and long-term plan to precisely target and unwork all the patterns that circle back to depression.

Luckily the entrypoint away from happiness is discernable and it is bittersweet: giving up, thereby reducing stress. Which is sweet at first, but turns into hell fast.

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