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Ibuprofen alters human testicular physiology

pnas.org

71–80 of 216 posts

Re: Ibuprofen alters human testicular physiology

#71

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

Is the /d per day? If so that's well within what I've seen "normal" people take.

A regular Advil is 200mg. The usual dose is two pills, so 400mg. If your larger it's common to take three or four pills. Multiply by a dose ever six hours and it's quite easy to get to 3200mg per day.

Re: Ibuprofen alters human testicular physiology

#72

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

Turmeric is my pain killer of choice.

Re: Ibuprofen alters human testicular physiology

#73

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

Nietzsche would advise against all forms of painkillers.

Re: Ibuprofen alters human testicular physiology

#74

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

Nietzsche would advise against all forms of painkillers.

why is that?

Re: Ibuprofen alters human testicular physiology

#75
post #54

I've taken entirely too much Ibuprofen - I've had a lot of babies. Since the sample size of this study is 31 people, I say that my one case is significant and this study is bunk. That's why you can't rely on a study of 31 people.

Of course. I'd much rather trust the anecdotes of a stranger on the internet

mlloyd has a point, the P value is right on the edge of significance and the study has only 31 people.

Take into account the bias that the negative result (no-correlation) would not pass the bar for publication and you likely have noise.

Re: Ibuprofen alters human testicular physiology

#76

How sufficient is a sample size of 31 healthy white men?

If you're asking if this is generalization to other healthy white men? It seems okay for a first shot. There is no fancy stats in this paper (they just use unpaired t-test to look for significance). They measured at two time points (+ the baseline condition) and both "real" (I don't really feel like including the Free T/LH ratio...) measurements that they found significantly different at minus 14 days remained significant (and same direction) at 44 days. The dose response curve seems particularly convincing to me.

It does seem that the particular study was centered around a single electrically stimulated exercise session. It would be difficult to try to guess what happens if combined with different (more sustained? more repeated?) exercise.

If you're asking if this is generalizable to any other group? No idea. Probably okay to generalize to all healthy men. But that's about it.

As for why this is so small? Looks like they just piggy backed on another study. Pretty reasonable use of resources.

Re: Ibuprofen alters human testicular physiology

#77
post #72

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

Turmeric is my pain killer of choice.

[deleted]

Re: Ibuprofen alters human testicular physiology

#78

Earlier quoted context omitted.

Can't use aspirin in children and teenagers because of the risk of Reye's Syndrome. https://www.mayoclinic.org/diseases-conditions/reyes-syndrom...

1000 cases in the US, which means you're about 30x more likely to die in a car accident in any given year. Also, the syndrome isn't immediately lethal. When people worry about infinitesimally small risks, it always makes me chuckle.

1000 cases in the US because there are no child friendly pain medications (sweet syrup and oral syringe) but by all means risk your child’s liver to prove us all wrong

Re: Ibuprofen alters human testicular physiology

#79

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

I can’t take Ibuprofen (or any typical NSAIDS including aspirin) because of a medical condition, which has sucked over the last decade because acetaminophen really doesn’t help me at all when I’m excruciatingly sore for whatever reason.

In Oregon and Washington, where I’ve lived for pretty much my entire life, legal marijuana has been amazingly helpful, at least since I finally got around to trying it.

The various products out that are high in CBD and low in psychoactive ingredients have been really good at even my worst muscle aches and really painful, but not super serious, injuries like sprained ankles and such.

My surgeon after hip surgery even blessed the notion of using the opiates I was prescribed for as short as possible and then using high CBD edibles to cover the gap between excruciating post-op pain subsiding but still being in a lot of pain. In fact, he didn’t just bless the idea, he practically endorsed it as a “still emerging but very likely positive course of treatment” in his words.

I don’t use CBD like someone might (even if maybe they shouldn’t) pop ibuprofen, but it’s great to have an option between acetomenaphin and opiates.

Re: Ibuprofen alters human testicular physiology

#80
post #16

Earlier quoted context omitted.

some people can't handle the effect on the stomach. but if you can handle it, it's a good choice. Or marijuana

> marijuana Unless that makes you anxious.

In that case, use ketamine?

In all seriousness though, there is research being done and evidence to suggest that ketamine can be used for pain management. Most of it seems to be about using it synergistically with opioids, to reduce the amount of opioids required.

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