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Aspirin May Prevent Cancer from Spreading, New Research Shows

scientificamerican.com

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Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#111

Post by icantdrive55 »

joshgel wrote: post #85
jaggederest wrote: post #53

Earlier quoted context omitted.

That is completely correct. It also has synergistic effects as a pain reliever, but it's mainly there to deter abuse. Of course, addicts have found ways to extract the opiates from the adulterants, so it's not even effective.

Source? Adding it for synergism makes sense and is what I was taught in medical school. I doubt they add it to deter abusers, but I could be wrong...

I think what you were taught in med school was correct.

I was told by an emergency room nurse that Vicodin is not killing patients/abusers; it the liver damage that results from the acetaminophen.

A few years ago, I heard they were talking about removing it, but lost track of the outcome.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#112

Post by vldx »

tdicola wrote: post #76
iplaw wrote: post #14

Earlier quoted context omitted.

I abstain from food between 8PM and 12PM Monday - Friday, adjusting for training schedules and such. It really helps me keep my GI tract clear, reduces inflammation, resulted in weight loss, etc. without any effect on my cycling fitness. IF (or IMF as some people call it) is amazing.

Train while fasted, you'll feel amazing trust me. I do a 16:8 daily fast too and do regular HIIT and strength training while fasted (in the morning). In the fasted state your body is producing more adrenaline and HGH which helps with performance and gains. It also trains your muscles to burn fat instead of sugar (since there's none available), which is incredible for endurance (run a half marathon or more on just wat…

I think training in completely fasted state is ok, but not optimal; you should be cautious not go dogmatic regarding that, as at given point it might halt your progress. From my relatively modest experience (as former client of Martin Berkhan) - BCAA and/or MCT oil prior the workout might yield substantial positives.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#113

Post by noam87 »

dmichulke wrote: post #108
noam87 wrote: post #54

(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2014) mentions it in passing in one of the later chapters. I believe there's even been trials where NSAID is applied topically during biopsy, reducing chance of mets. If I recall correctly, suspected mechanism is some sort of correlation between COX-2 inhibition…

> Even the standard book "The Biology Of Cancer" (2014) mentions it Is this book ok for people with other backgrounds or does it require a good foundation in medicine or biology? And could a programmer (that knows how to learn) deal with it without spending months on research? Thanks and all the best wishes!

um some parts are more high-level than others, but a lot would be gibberish. Familiarity with the contents of e.g "Molecular Biology Of The Cell" would greatly increase your experience. -- That book is big and exhaustive (and expensive), a focused intro to the same material is MIT "Introduction To Biology" on EDx! It's an amazing course!

The book and MIT course also give a good enough conceptual intro to the chemistry concepts you need too. Obviously the rabbit hole goes deeep tho... people spend lifetimes scratching the surface.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#114

Post by ahh »

tptacek wrote: post #15
iplaw wrote: post #14

Earlier quoted context omitted.

I abstain from food between 8PM and 12PM Monday - Friday, adjusting for training schedules and such. It really helps me keep my GI tract clear, reduces inflammation, resulted in weight loss, etc. without any effect on my cycling fitness. IF (or IMF as some people call it) is amazing.

I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)

How much do you work out?

I like IF a lot too, but when I'm in a heavily active phase of my life--say lifting 3x week, climbing 1x, jiujitsu 3x, and full on dance rehearsals 3x a week--I find I start to crumble unless I eat more to keep fueled.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#115

Post by tptacek »

ahh wrote: post #114
tptacek wrote: post #15

Earlier quoted context omitted.

I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)

How much do you work out? I like IF a lot too, but when I'm in a heavily active phase of my life--say lifting 3x week, climbing 1x, jiujitsu 3x, and full on dance rehearsals 3x a week--I find I start to crumble unless I eat more to keep fueled.

I was 5x5 when I started, for about 6 months, then hurt my ankle and don't do much more than walk a couple miles now. I worked out in fasted state and then would eat shortly after, because I'd be so ravenous that I could eat just protein and still enjoy the meal.

I should get back to lifting (I'm just lazy), and it's possible that some of the other purported IF effects would kick in if I did so --- but the literature isn't encouraging, at least what I've read (I may be reading the wrong stuff!).

I should add: I'm in pretty terrible shape! I joked on Twitter about how, in the post-AHCA US, my wife Erin will have trouble getting insurance despite her constant exercise and diet regime, while I, subsisting on pork fat, nicotine, and whiskey, will have no trouble. I mean, I eat a green bean here and there, but for the most part I'm not joking. :)

I don't have a lot of health objectives with IF; it's just mostly painless and imposes some structure over what I eat and when I have to take time out of my day to eat.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#116

Post by killjoywashere »

oxide wrote: post #102
killjoywashere wrote: post #100

Earlier quoted context omitted.

> I've personally never seen it given more than 325mg daily. Really? Lortab 5/500?

is tylenol, not aspirin. unless the formulation has changed. I'm not sure of any generic formulations of hydrocodone that are made with aspirin and widely prescribed. there are some like Percodan but those are 5/325 AFAIK and oxycodone, not hydrocodone. I'm not a doctor though, just a nerd.

Lortab has all sorts of variations, 500 mg aspirin being one: https://www.drugs.com/imprints/500-4519.html

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#117

Post by joelthelion »

oxide wrote: post #49
salmonet wrote: post #41

Earlier quoted context omitted.

I would go out on a limb and say it's a LOT of Asprin. I usually use "surprising" on HN because anything more specific gets criticized surprisingly often, but that is a ton of asprin

it's a veritable fuck-ton. the usual modern dose is 325mg.

In the US. It's higher in France, for example.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#118

Post by fanf2 »

Swizec wrote: post #31
tptacek wrote: post #15

Earlier quoted context omitted.

I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)

I have the opposite experience. My body and mind function best with regular small meals every 3 or 4 hours. With that regime I have constant energy without ups and lulls. It's great. When I do go too long without eating, I feel fine and I don't feel particularly hungry. But people around me say that I become uncommunicative, quarelsome, and that I tend to just kind of sit there and stare in front of me unmovingly. Pe…

Classic example of being low-level "hangry": hungry/angry. Beware of it in children when simple lack of food can spill over into full-blown tantrums!

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#119

Post by mixmastamyk »

Swizec wrote: post #57
mixmastamyk wrote: post #42

Earlier quoted context omitted.

Might be eating too many carbs, which spike blood sugar, and tend to produce the symptoms you mention. Still, don't need to fast all day to fix the problem.

Funnily only about 30% of my calories come from carbs. Except on half marathon days. I can't digest enough food to recover from a 2000 calorie run without carbs I've tried going below 30% carbs but it makes me unstoppably crave chocolate.

I eat the ghirardelli dark chocolate (72 and 86%) often, it is healthy and low sugar. It's not the enemy. ;)

https://www.ghirardelli.com/chocolate-and-gifts/flavors/dark...

There are similar European varieties of course.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#120

Post by iplaw »

ahh wrote: post #114
tptacek wrote: post #15

Earlier quoted context omitted.

I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)

How much do you work out? I like IF a lot too, but when I'm in a heavily active phase of my life--say lifting 3x week, climbing 1x, jiujitsu 3x, and full on dance rehearsals 3x a week--I find I start to crumble unless I eat more to keep fueled.

I ride 6 days a week for 1 to 5 hours per ride. 4 training rides, 2 recovery rides, and one off day per week. In terms of energy expenditure, it averages 700-900 calories/hour. A weeknight training crit and/or weekend races often replace the training days mid-season, and the schedule is tweaked for peaking at my A events.

For major events, I'll eat differently. But for general training, I am fine fasting until lunch.

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