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Aspirin May Prevent Cancer from Spreading, New Research Shows

scientificamerican.com

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Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#101

Post by [deleted] »

killjoywashere wrote: post #99
noam87 wrote: post #54

(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2014) mentions it in passing in one of the later chapters. I believe there's even been trials where NSAID is applied topically during biopsy, reducing chance of mets. If I recall correctly, suspected mechanism is some sort of correlation between COX-2 inhibition…

Erm... that's actually a great book. I'm part-way through it, but set it down a while back because somewhere around chapter 10 I felt like I was up against the law of diminishing returns. If you could happen to get me a page reference, I'd appreciate it.

[deleted]

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#102

Post by oxide »

killjoywashere wrote: post #100
joshgel wrote: post #82

Earlier quoted context omitted.

Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.

> I've personally never seen it given more than 325mg daily. Really? Lortab 5/500?

is tylenol, not aspirin. unless the formulation has changed.

I'm not sure of any generic formulations of hydrocodone that are made with aspirin and widely prescribed.

there are some like Percodan but those are 5/325 AFAIK and oxycodone, not hydrocodone.

I'm not a doctor though, just a nerd.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#103

Post by greggman »

joshgel wrote: post #82
libdong wrote: post #66

Earlier quoted context omitted.

The maximum daily dose is usually around 4g. 325mg is probably the dose in one tablet.

Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.

Isn't tylenol fairly dangerous?

https://www.thisamericanlife.org/radio-archives/episode/505/...

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#104

Post by taneq »

oxide wrote: post #52
mod wrote: post #38

Earlier quoted context omitted.

What's 'regular?' I use ibprufen exclusively, without stomach issues. But not daily. I probably take it once per week on average. Usually when lacking caffeine has caused a headache. Or eyestrain, occasionally. Those are probably the issues I should fix, though.

>But not daily. I probably take it once per week on average. My grandmother shits and pukes blood if she takes NSAIDs of any kind, from long-term, daily misuse. I'm not exaggerating even a little bit, I wish I was. A direct result of being denied access to proper pain relief, mind you, mainly because she lived her entire life without health insurance. Until she turned 65 and qualified for Medicare last year. I had to…

After surgery I was prescribed an NSAID called Naproxen. It's apparently much easier on the stomach than Ibuprofen, but has a very slightly higher chance of causing a heart attack or stroke.

I think this is one of those situations where they'd rather a thousand people be miserable and wreck their stomachs than one person drop dead and cause a lawsuit.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#105

Post by taneq »

iplaw wrote: post #14
erikpukinskis wrote: post #10

Because it's anti-inflammatory? Could be confirmation bias, but I keep getting the sense that cancer/immune failure in general is connected to our modern 24/7 eating cycle, without any down time for your body to not be inflamed and work on clearing out bad stuff. Thus life extension from intermittent fasting.

I abstain from food between 8PM and 12PM Monday - Friday, adjusting for training schedules and such. It really helps me keep my GI tract clear, reduces inflammation, resulted in weight loss, etc. without any effect on my cycling fitness. IF (or IMF as some people call it) is amazing.

That's a really fancy way to say "I skip breakfast".

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#106

Post by taneq »

tptacek wrote: post #18
ianai wrote: post #17

Earlier quoted context omitted.

What's the trick? I wake up starving. If I go to bed starving I sleep horribly and eventually wake up to eat.

My understanding is that it doesn't work the same way for everyone. My theory is just that if you're insulin sensitive, then concentrating your eating to one small part of the day levels your blood sugar and hormones out for the rest of the day. My experience is: once I start eating during a day, I will be hungry for the rest of the day. If I just don't eat, I basically don't ever get hungry: I'll know it's time to e…

That's why you shouldn't skip breakfast entirely when you're dieting (at least that's what I've read). The stomach 'wakes up' when you first eat something, and uses more energy from that point on. If you eat something small, you'll feel hungry for more of the morning - because the extra activity from your stomach puts you in energy debt.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#107

Post by ihaveahadron »

"Investigators are thus trying to develop genetic tests to determine who is most likely to benefit from long-term use of aspirin"

Oh did we figure out the problem with modern medicine is that were all different subspecies of humans, or to simplify it you could say species for the slow people. Its like having prescribing the same drug to a blonde haired blue eyed person to a rat, or for you not slow people, like prescribing not to a rat but to say a bacteria. FUXKING RETARDEDPAINT HIFFING FAGGOT DOCTORS

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#108

Post by dmichulke »

noam87 wrote: post #54

(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2014) mentions it in passing in one of the later chapters. I believe there's even been trials where NSAID is applied topically during biopsy, reducing chance of mets. If I recall correctly, suspected mechanism is some sort of correlation between COX-2 inhibition…

> Even the standard book "The Biology Of Cancer" (2014) mentions it

Is this book ok for people with other backgrounds or does it require a good foundation in medicine or biology?

And could a programmer (that knows how to learn) deal with it without spending months on research?

Thanks and all the best wishes!

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#109

Post by Muuuchem »

joshgel wrote: post #82
libdong wrote: post #66

Earlier quoted context omitted.

The maximum daily dose is usually around 4g. 325mg is probably the dose in one tablet.

Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.

Acetaminophen != NSAID

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#110

Post by Muuuchem »

greggman wrote: post #103
joshgel wrote: post #82

Earlier quoted context omitted.

Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.

Isn't tylenol fairly dangerous? https://www.thisamericanlife.org/radio-archives/episode/505/...

Toxic to the liver in large or frequent dosage.
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