(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2014) mentions it in passing in one of the later chapters. I believe there's even been trials where NSAID is applied topically during biopsy, reducing chance of mets. If I recall correctly, suspected mechanism is some sort of correlation between COX-2 inhibition…
There's documentation of firocoxib (a partially selective COX-2 inhibitor used in veterinary medicine) with efficacy against osteosarcoma, for instance.
Even a small amount of Asprin, if taken regularly, will mess up your stomach in my experience! I guess not everyone is sensitive to it, but for me I've avoided Asprin (and Ibuprofen, another NSAID drug) for years because of this.
What's 'regular?' I use ibprufen exclusively, without stomach issues. But not daily. I probably take it once per week on average. Usually when lacking caffeine has caused a headache. Or eyestrain, occasionally. Those are probably the issues I should fix, though.
I had some back problems and was reliant on ibuprofen for a few years. By the time I stopped taking them, I had to choose between back pain/ not being able to walk, or throwing up blood and not being able to eat.
What's 'regular?' I use ibprufen exclusively, without stomach issues. But not daily. I probably take it once per week on average. Usually when lacking caffeine has caused a headache. Or eyestrain, occasionally. Those are probably the issues I should fix, though.
>But not daily. I probably take it once per week on average. My grandmother shits and pukes blood if she takes NSAIDs of any kind, from long-term, daily misuse. I'm not exaggerating even a little bit, I wish I was. A direct result of being denied access to proper pain relief, mind you, mainly because she lived her entire life without health insurance. Until she turned 65 and qualified for Medicare last year. I had to…
Add me to the anecdotal evidence there. A regular dose of ibuprofen and I can't eat and I throw up blood for a day..
Acetaminophen in particular is somewhat scary. Just 2.5x the recommended maximal daily dose of 4g can lead to complete liver failure. With alcohol, other medication, or existing damage, much less could be enough.
A friend of mine swears that the reason acetaminophen is added to opioids (like hydrocodone) is so that you cant abuse the opioid without being poisoned by the acetaminophen. If true, it's alarming that the way to "prevent abuse" is to poison the patient.
You can buy codeine over the counter in the UK, in doses of 8mg with 500mg acetaminophen(paracetamol to us). If you get a prescription, they happily bump it to 30/500
Acetaminophen in particular is somewhat scary. Just 2.5x the recommended maximal daily dose of 4g can lead to complete liver failure. With alcohol, other medication, or existing damage, much less could be enough.
A friend of mine swears that the reason acetaminophen is added to opioids (like hydrocodone) is so that you cant abuse the opioid without being poisoned by the acetaminophen. If true, it's alarming that the way to "prevent abuse" is to poison the patient.
Isn't their anything that is uncomfortable in higher doses, but not deadly? Or have I misunderstood what I read about acetaminophen and/or liver failure–i. e. is there a meaningful dosage range where it's uncomfortable without causing irreparable harm?
Because it's anti-inflammatory? Could be confirmation bias, but I keep getting the sense that cancer/immune failure in general is connected to our modern 24/7 eating cycle, without any down time for your body to not be inflamed and work on clearing out bad stuff. Thus life extension from intermittent fasting.
I abstain from food between 8PM and 12PM Monday - Friday, adjusting for training schedules and such. It really helps me keep my GI tract clear, reduces inflammation, resulted in weight loss, etc. without any effect on my cycling fitness. IF (or IMF as some people call it) is amazing.
Train while fasted, you'll feel amazing trust me. I do a 16:8 daily fast too and do regular HIIT and strength training while fasted (in the morning). In the fasted state your body is producing more adrenaline and HGH which helps with performance and gains. It also trains your muscles to burn fat instead of sugar (since there's none available), which is incredible for endurance (run a half marathon or more on just water? no problem).
I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)
What's the trick? I wake up starving. If I go to bed starving I sleep horribly and eventually wake up to eat.
Eat low carb when you're feasting. I.e. stop eating sugar and grains that make your body crave and depend on them for energy all the time. Get off the insulin rush rollercoaster.
Because it's anti-inflammatory? Could be confirmation bias, but I keep getting the sense that cancer/immune failure in general is connected to our modern 24/7 eating cycle, without any down time for your body to not be inflamed and work on clearing out bad stuff. Thus life extension from intermittent fasting.
Plant based diets are largely anti - inflammatory and Aspirin is essentially a processed phytonutrient.
I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)
I do the same as well. It pretty much has changed my life. The only thing I have noticed is that it seems not work well for females (my wife is annoyed about that). Also strangely my blood sugar has been above normal lately which is strange because I don't eat a carb heavy diet and I have never had blood sugar problems. Last time it was checked it was ~105 mg/dl or so (and I was fasted of course). I have had some the…
Stress and lack of sleep can dramatically raise blood sugar. I don't have diabetes but I check my blood sugar fairly regularly with a $30 glucose monitor. Bad sleep raises my fasting blood sugar to a level I would normally have after a bowl of ice cream.
What's the trick? I wake up starving. If I go to bed starving I sleep horribly and eventually wake up to eat.
My understanding is that it doesn't work the same way for everyone. My theory is just that if you're insulin sensitive, then concentrating your eating to one small part of the day levels your blood sugar and hormones out for the rest of the day. My experience is: once I start eating during a day, I will be hungry for the rest of the day. If I just don't eat, I basically don't ever get hungry: I'll know it's time to e…
Huh - I feel that way with regards to food, in that once I eat I keep wanting to the rest of the day. Maybe I'll give this a shot...