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Aspirin May Prevent Cancer from Spreading, New Research Shows

scientificamerican.com

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Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#41

Post by salmonet »

benji-york wrote: post #19
nonbel wrote: post #11

There are some interesting theories about aspirin. For example that it was Rasputin's secret healing trick to tell people to stop taking it: "Gilliard,[32] the French historian Hélène Carrère d'Encausse[33] and Diarmuid Jeffreys, a journalist, speculated Rasputin's healing practice included halting the administration of aspirin, a pain-relieving analgesic available since 1899.[34] Aspirin is an antiaggregant and has…

> 8.0–31.2 g per day That is surprising amount of aspirin.

I would go out on a limb and say it's a LOT of Asprin. I usually use "surprising" on HN because anything more specific gets criticized surprisingly often, but that is a ton of asprin

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#42

Post by mixmastamyk »

Swizec wrote: post #31
tptacek wrote: post #15

Earlier quoted context omitted.

I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)

I have the opposite experience. My body and mind function best with regular small meals every 3 or 4 hours. With that regime I have constant energy without ups and lulls. It's great. When I do go too long without eating, I feel fine and I don't feel particularly hungry. But people around me say that I become uncommunicative, quarelsome, and that I tend to just kind of sit there and stare in front of me unmovingly. Pe…

Might be eating too many carbs, which spike blood sugar, and tend to produce the symptoms you mention.

Still, don't need to fast all day to fix the problem.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#43

Post by mrfusion »

agentgt wrote: post #22
tptacek wrote: post #15

Earlier quoted context omitted.

I've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)

I do the same as well. It pretty much has changed my life. The only thing I have noticed is that it seems not work well for females (my wife is annoyed about that). Also strangely my blood sugar has been above normal lately which is strange because I don't eat a carb heavy diet and I have never had blood sugar problems. Last time it was checked it was ~105 mg/dl or so (and I was fasted of course). I have had some the…

What's your theory about the blood sugar?

I have the same issue. Hovers around 100 when not eating. What's weird is it drops to 85 within 20 minutes after eating a meal. I'm not sure what that could mean.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#44

Post by nostromo »

matt4077 wrote: post #37
mtgx wrote: post #21

Earlier quoted context omitted.

Does that mean the risks are very low? What about compared to aspirin alternatives such as ibuprofen or acetaminophen (in terms of how much damage they can each cause to the body, and which is safer)?

Acetaminophen in particular is somewhat scary. Just 2.5x the recommended maximal daily dose of 4g can lead to complete liver failure. With alcohol, other medication, or existing damage, much less could be enough.

A friend of mine swears that the reason acetaminophen is added to opioids (like hydrocodone) is so that you cant abuse the opioid without being poisoned by the acetaminophen.

If true, it's alarming that the way to "prevent abuse" is to poison the patient.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#45

Post by smeyer »

mtgx wrote: post #21
aantix wrote: post #16

As for the internal bleeding risks, I was wondering what the actual numbers were. This is based on one low dose aspirin a day. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.... "These results translate into an absolute rate increase with aspirin above placebo (the incidence of cases of major GI bleeding attributable to low-dose aspirin) of 0.12% per year (95% CI: 0.070.19% per year).[20] Based on this v…

Does that mean the risks are very low? What about compared to aspirin alternatives such as ibuprofen or acetaminophen (in terms of how much damage they can each cause to the body, and which is safer)?

Are those really alternatives in this context? The linked study highlights

>Low-dose aspirin, commonly defined as 75–325 mg daily, is used for primary and secondary prevention of cardiovascular events such as myocardial infarction (MI).

The whole purpose of aspirin here is its blood-thinning properties and the effect this has on cardiovascular events. Do ibuprofen and acetaminophen have those same properties, or are you just calling them alternatives in terms of pain relief or other applications?

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#46

Post by NotHereNotThere »

tossaway1 wrote: post #40
carbocation wrote: post #32

Earlier quoted context omitted.

Aspirin (previously erroneously typed cancer , hat tip to 'tossaway1 for the correction!) has previously been associated with reduced colorectal cancer death[1]. The cancer/aspirin link has come up a fair amount over the past few decades. 1 = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354696/

Cancer has been associated with colorectal cancer death??

He obviously meant to type "aspirin" as the first word, but that was hilarious nonetheless.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#47

Post by ghaff »

matt4077 wrote: post #37
mtgx wrote: post #21

Earlier quoted context omitted.

Does that mean the risks are very low? What about compared to aspirin alternatives such as ibuprofen or acetaminophen (in terms of how much damage they can each cause to the body, and which is safer)?

Acetaminophen in particular is somewhat scary. Just 2.5x the recommended maximal daily dose of 4g can lead to complete liver failure. With alcohol, other medication, or existing damage, much less could be enough.

It's arguable that Acetaminophen shouldn't be an OTC drug. And that, had its liver toxicity been fully understood, it probably wouldn't be.

At the time, it apparently seemed a good alternative to aspirin which does cause some number of people to have stomach problems. (As well as having a particularly extensive repertoire of only somewhat understood physiological effects, for better or worse.)

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#48

Post by protomyth »

Reason077 wrote: post #27
jszymborski wrote: post #24

Earlier quoted context omitted.

you know what they say, ten aspirin tablets a-day keeps the emergency room busy.

Even a small amount of Asprin, if taken regularly, will mess up your stomach in my experience! I guess not everyone is sensitive to it, but for me I've avoided Asprin (and Ibuprofen, another NSAID drug) for years because of this.

Given the doctors seem to be telling everyone over 50 to take a daily aspirin, I would think that a goodly chunk of people aren't sensitive. It might be the low dose people are taking.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#49

Post by oxide »

salmonet wrote: post #41
benji-york wrote: post #19

Earlier quoted context omitted.

> 8.0–31.2 g per day That is surprising amount of aspirin.

I would go out on a limb and say it's a LOT of Asprin. I usually use "surprising" on HN because anything more specific gets criticized surprisingly often, but that is a ton of asprin

it's a veritable fuck-ton. the usual modern dose is 325mg.

Re: Aspirin May Prevent Cancer from Spreading, New Research Shows

#50

Post by carbocation »

NotHereNotThere wrote: post #46
tossaway1 wrote: post #40

Earlier quoted context omitted.

Cancer has been associated with colorectal cancer death??

He obviously meant to type "aspirin" as the first word, but that was hilarious nonetheless.

Ha! :-) Thanks to both of you for noticing this. Updated.
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