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Smoking “causes hundreds of DNA changes”

bbc.com

71–80 of 259 posts

Re: Smoking “causes hundreds of DNA changes”

#71
post #25

Earlier quoted context omitted.

I wonder if there is just about anything (other than water) that you can put in your body that wouldn't have some effect on the mutation rate of some particular cells in your body.

Plants, fruits, starchy vegetables..

Tobacco is a plant!

A wonderfully aromatic plant …

Re: Smoking “causes hundreds of DNA changes”

#72

Earlier quoted context omitted.

I've once read somewhere that they polled heroin addicts, asking them what they'd rather do first time they wake up in the morning - shoot heroin or smoke a cigarette. Of course the vast majority said they'd smoke a cigarette. I've never been a heroin addict, but I've been a tobacco smoker for many years and I can confirm that smoking a cig was definitely the most important thing I had to do in the morning. Also if I…

What kinds of cigarettes were you smoking exactly?

I started with Lucky Strike, then smoked Marlboro Lights for about 18 years, then the last two years or so I smoked organic rolling tobacco - Cross Road.

I've stopped smoking 18 months ago, but even after 1.5 years, I still get the urge to smoke almost every day.

Re: Smoking “causes hundreds of DNA changes”

#73
post #23

Earlier quoted context omitted.

Considering opiate withdraw can cause death I'd say tobacco is less addictive

Actually I believe clinically, "addictiveness" is measured by what it takes to develop a dependence in the first place, rather that what it takes to get rid of that dependence or even the physical effects of an abrupt cessation. I heard somewhere (sorry no references) that by that measure, nicotine is one of if not the most addictive substance known.

I think you need very large quantities of whatever is in tobacco that makes you addicted to have physical dependency on it. (Is it nicotine?)

I smoke a pipe on weekends. I have no physical craving for tobacco during the week and sometimes I just don't want to even on the weekends. The most amount of cigarettes I had throughout my life was probably equal to one pack and I never inhaled it because I don't feel like choking on smoke.

The worst effect I get with nicotine is dizziness but never any physical dependency or withdrawal from its absence in my body.

I just wish they did more studies on the effects of occasional use of tobacco, via pipes and cigars to see the effect of what occasional smoking does to someone.

Re: Smoking “causes hundreds of DNA changes”

#74
post #70

I wonder if there were studies that analyzed the effect of smoking non-industrialized cigarettes. I smoke 2-4 cigarettes per day and make my own cigarettes from tobacco leaves that I dry/shred myself. The leaves in turn come from a few organically grown plants.

Also, you are controlling your own dose (by how big you roll and pack your cigarette), no?

I feel with industrialized cigarettes, most users feel obligated to consume it completely.

My father-in-law would smoke a portion of the cigarette, put it out, and resume later.

Re: Smoking “causes hundreds of DNA changes”

#75
post #27

This has some legal implications. You can now prove fairly conclusively that your lung cancer came from smoking. I wonder if it will lead to a new wave of tobacco litigation. I think even Fisher would be convinced [1]. [1] https://priceonomics.com/why-the-father-of-modern-statistics...

Smokers were already and for a long time aware of the risks. They choose to take them. What could they possibly claim? That a product known for causing lung cancer caused lung cancer?

I think that in all other areas it's been on the manufacturer of products to make them safer over time (cars, children's toys, cosmetics etc.) so shouldn't the tobacco companies be trying to make their product safer?

Re: Smoking “causes hundreds of DNA changes”

#76
post #68
post #56

Earlier quoted context omitted.

Very interesting, does look promising indeed. However, currently it still seems unclear that they have enough data to say with certainty that these "signatures" are unique or complete. From your source: > With more cancer genome sequences and the additional statistical power this will bring, new signatures may be found, the profiles of current signatures may be further refined, signatures may split into component sig…

These signatures will never be unique or complete. Remind you that this is biology where there is not the TRUTH to be found. At some point you can always subdivide one phenomenon in to two cases. These signatures are generated from non-negative matrix factorization which generates signature vectors more or less stable depending on the amount of input datasets and the number of signatures you want to obtain. And at so…

You leave out the fact that there is a known carcinogenic mechanism for smoking, and this corresponds to the signature derived by NMF. In vitro studies in controlled systems exposed to smoking carcinogens also reproduce this signature. In addition to the NMF signature, there are other features like transcriptional strand bias, and dinucleotide substitutions. This is a bit more than an association.

Re: Smoking “causes hundreds of DNA changes”

#77

Earlier quoted context omitted.

What kinds of cigarettes were you smoking exactly?

I started with Lucky Strike, then smoked Marlboro Lights for about 18 years, then the last two years or so I smoked organic rolling tobacco - Cross Road. I've stopped smoking 18 months ago, but even after 1.5 years, I still get the urge to smoke almost every day.

How old were you when you first smoked?

I have anecdotally heard that if one had not smoked by adulthood, chances of addiction are fairly low.

Re: Smoking “causes hundreds of DNA changes”

#78
post #70

I wonder if there were studies that analyzed the effect of smoking non-industrialized cigarettes. I smoke 2-4 cigarettes per day and make my own cigarettes from tobacco leaves that I dry/shred myself. The leaves in turn come from a few organically grown plants.

Also, you are controlling your own dose (by how big you roll and pack your cigarette), no? I feel with industrialized cigarettes, most users feel obligated to consume it completely. My father-in-law would smoke a portion of the cigarette, put it out, and resume later.

Oh, sure, you can control the size/dose - mines are slightly shorter/thinner than normal cigarettes.

Re: Smoking “causes hundreds of DNA changes”

#79

Earlier quoted context omitted.

Alcohol (ethanol) is a Type 1 / Group A carcinogen.[1] 1. http://www.cancer.org/cancer/cancercauses/othercarcinogens/g...

And surprisingly no mass deaths from cancer of Russians or Irish were detected, with both nations famous for alcohol abuse. Yes, alcohol is harmful, but like Russians joke, it only kills weak brain cells.

Maybe a lot of people die before they get cancer from it? Like organ failure (liver, kidney, heart) way before they develop cancer (symptoms)? Or get into accidents (car, freezing to death) etc. It is like people saying smoking can prevent Alzheimer as statistically people who smoke a lot have less instances of it. Because they die from that habit before the Alzheimer shows up.

Re: Smoking “causes hundreds of DNA changes”

#80
post #59

Earlier quoted context omitted.

Hitting yourself repeatedly over the head with a hammer can give you a headache. Not sure DeWalt are worried from a litigious point of view. I doubt there is a smoker alive today who can reasonably claim to have been unaware of the risks when they started. Anal point - why the apostrophe? Should it be "Smoking becauses hundreds..."?

There is literally a 69 year old woman in the article who claims just that: > "Had I known as a teenager that smoking caused mutations which would stay with me for life then I would never had started" It agree with you that it's a little silly, especially for young people, but it wasn't that long ago they started forcing cancer warnings on tobacco.

I'm an ex-smoker and I had the same thought as I read the article: I wish I'd known this.

But really, I know it wouldn't have made a difference. From an early age I was taught at school that smoking would kill me and I started anyway. The idea that detailed knowledge of one particular cause of death would have made a difference is laughable. It's just a way of deflecting blame from one's own responsibility.

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