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Smoking “causes hundreds of DNA changes”

bbc.com

51–60 of 259 posts

Re: Smoking “causes hundreds of DNA changes”

#51
post #27

This has some legal implications. You can now prove fairly conclusively that your lung cancer came from smoking. I wonder if it will lead to a new wave of tobacco litigation. I think even Fisher would be convinced [1]. [1] https://priceonomics.com/why-the-father-of-modern-statistics...

Smokers were already and for a long time aware of the risks. They choose to take them. What could they possibly claim? That a product known for causing lung cancer caused lung cancer?

Re: Smoking “causes hundreds of DNA changes”

#54
post #27

This has some legal implications. You can now prove fairly conclusively that your lung cancer came from smoking. I wonder if it will lead to a new wave of tobacco litigation. I think even Fisher would be convinced [1]. [1] https://priceonomics.com/why-the-father-of-modern-statistics...

Hitting yourself repeatedly over the head with a hammer can give you a headache. Not sure DeWalt are worried from a litigious point of view. I doubt there is a smoker alive today who can reasonably claim to have been unaware of the risks when they started.

Anal point - why the apostrophe? Should it be "Smoking becauses hundreds..."?

Re: Smoking “causes hundreds of DNA changes”

#55

Earlier quoted context omitted.

You can always go for vaporizers. Are vaporizers actually ever used on tobaco? (i think they're sold "for tobaco use only" like bongs?)

As a pipe smoker, I can tell that vaporisers work with synthetic liquids containing synthetical nicotine, nothing to do with harms and benefits of tobacco. You could use nicotine plasters with the same effect.

I was talking about vaporizers where you put the thing that you usually burn in there, not some kind of liquid. Example: http://sales.magic-flight.com/original-maple-launch-box-kit/

Re: Smoking “causes hundreds of DNA changes”

#56
post #36
post #30

Earlier quoted context omitted.

I'm not sure that this could prove that. I believe that the mutation rate for non-smokers that develop lung cancer should be elevated as well. Perhaps there is a statistical difference, but it might not be easy to prove with certainty.

The tobacco signature goes beyond elevated rate, it has a sequence specific pattern (see http://cancer.sanger.ac.uk/cosmic/signatures ).

Very interesting, does look promising indeed. However, currently it still seems unclear that they have enough data to say with certainty that these "signatures" are unique or complete.

From your source:

> With more cancer genome sequences and the additional statistical power this will bring, new signatures may be found, the profiles of current signatures may be further refined, signatures may split into component signatures and signatures may be found in cancer types in which they are currently not detected.

Re: Smoking “causes hundreds of DNA changes”

#57

Earlier quoted context omitted.

As a pipe smoker, I can tell that vaporisers work with synthetic liquids containing synthetical nicotine, nothing to do with harms and benefits of tobacco. You could use nicotine plasters with the same effect.

I was talking about vaporizers where you put the thing that you usually burn in there, not some kind of liquid. Example: http://sales.magic-flight.com/original-maple-launch-box-kit/

Thank you, interesting boxes. I understood that whole assembly works like portable shisha, which is a good way to smoke certain tobaccos.

Re: Smoking “causes hundreds of DNA changes”

#58
post #17
post #11

Earlier quoted context omitted.

That's definitely not obvious. I would agree that mutations due to smoking could be in majority harmful due to the chemical components and the high temperatures involved. Other than that, a mutation is a mutation, whether due to smoke, nuclear irradiation, high altitude, or chance. In all cases, they can be beneficial or harmful. The evolution process will then cause only the beneficial ones to perdure.

> The evolution process will then cause only the beneficial ones to perdure. This isn't correct and is a common misconception about evolution. The process which does this is natural selection, and it only occurs through the organism being unable to reproduce as well as an organism with beneficial evolutionary changes. With humans in the modern world, there is no natural selection because of state benefits that keep p…

I think he means generally among all species and not particularly people in last 200 years.

Re: Smoking “causes hundreds of DNA changes”

#59
post #27

This has some legal implications. You can now prove fairly conclusively that your lung cancer came from smoking. I wonder if it will lead to a new wave of tobacco litigation. I think even Fisher would be convinced [1]. [1] https://priceonomics.com/why-the-father-of-modern-statistics...

Hitting yourself repeatedly over the head with a hammer can give you a headache. Not sure DeWalt are worried from a litigious point of view. I doubt there is a smoker alive today who can reasonably claim to have been unaware of the risks when they started. Anal point - why the apostrophe? Should it be "Smoking becauses hundreds..."?

There is literally a 69 year old woman in the article who claims just that:

> "Had I known as a teenager that smoking caused mutations which would stay with me for life then I would never had started"

It agree with you that it's a little silly, especially for young people, but it wasn't that long ago they started forcing cancer warnings on tobacco.

Re: Smoking “causes hundreds of DNA changes”

#60
A significant amount of the shredded brown innards of most modern cigarettes is a paper product called "reconstituted tobacco" or "homogenized sheet tobacco," which is made from a pulp of mashed tobacco stems and other parts of the tobacco leaf that would otherwise go to waste. Manufacturers spray and impregnate reconstituted tobacco paper with nicotine and other substances lost during the process, along with as many as 600 chemical additives. These include several that may come as a surprise, such as ammonia, which aids in the delivery of nicotine, and chocolate, which masks the bitter taste of tobacco. Finally, the 'recon' is sliced to resemble shredded leaf tobacco. So basically good research should compare people smoking quality cuban (once a week) with pipe smoker (once a day) with this poor creature addicted to synthetical 'tobacco' on her 20/day. And of course, since urban people are exposed to contaminated air from cars, control group must be taken from rural areas. I predict result that tobacco is not responsible for lung cancer, in absence of other air contamination factors. You know, more than 90% of people with lung cancer ate cucumbers. So think twice before blaming tobacco.
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