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New insights into why aspirin works so well

eurekalert.org

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Re: New insights into why aspirin works so well

#81

Post by plugin-baby »

consp wrote: post #71
zabzonk wrote: post #8

annecdata: aspirin is pretty good as an anti-inflamitory and hence pain-killer. the reason i don't take it is that it irritates the stomach, and i have enough issues with my insides as it is (irritable-bowel syndrome - not fun) i currently use cocodamol (codeine and paracetomol) to control my arthritic pain, but it isn't doing so great. at the end of the day, if you really need pain control, you probably want a pure…

You might be a poor codeine metaboliser. My mom and I both have this and need about twice the normally prescribed amount to have any workable effect. Always check with a medical professional before assuming you are since if it's the reverse you could easily od yourself due to rapid metabolisation of codeine to morphine.

Doubling your dose of cocodamol is a bad idea for the paracetamol too.

Re: New insights into why aspirin works so well

#82

Post by 11235813213455 »

TheSpiceIsLife wrote: post #74
11235813213455 wrote: post #47

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

I wouldn't know how old you are, some people just have such wildly good genetics they can smoke and drink till they get hit by a bus jogging at night at 98 years old. Other people don't, you wave a celery stick near them and they put on eight pounds, a pollen particle passes within thirty kilometres of them and they're hayfever nearly kills them.

yes but I really believe it doesn't have much to do with genetics, like for intelligence. It's more the lifestyle, eating as much vegetable as possible, raw, fermented, I eat rice as well, working remotely definitely helped too, outdoor exercise (bike as a vehicle) or just walking, sun exposure, cold showers (because it's broken and it's not unpleasant as well), no heating as well all year long (south of France) so my body is trained to heat and probably have good immunity

Re: New insights into why aspirin works so well

#83

Post by 11235813213455 »

swidi wrote: post #59
11235813213455 wrote: post #47

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

Yes, and everybody here thinks you're a brave little boy. Have a lollipop.

yea and if you think a bit more, you could see it's applicable to almost everyone. This article explains how it's counter-productive to do anything else, there are working on new molecules that will be found later than similarly they inhibit something else..

Re: New insights into why aspirin works so well

#84

Post by kensai »

9dev wrote: post #60
11235813213455 wrote: post #47

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

The body handles inflammations just fine, but you can actively help it to get it done more quickly. Doesn't have to be Aspirin though, chamomile tea and lots of other things work wonders, too.

Although HN is not a medical site, comments like yours need a disclaimer. Cause even the phrase “the body handles inflammations just fine” needs a it depends clarifier.

Re: New insights into why aspirin works so well

#85

Post by glass3 »

zabzonk wrote: post #37
glass3 wrote: post #29

Earlier quoted context omitted.

If you haven't seen it: >consumer451 3 months ago | next [–] >I was diagnosed with arthritis at a very young age. [...] >One day I learned about modifying my diet to avoid inflammation. I greatly limited, but did not entirely eliminate, tomatoes and potatoes in my diet. >[...] https://news.ycombinator.com/item?id=34163231

unhappily, i was diagnosed with arthritis at quite an old age (60+) after happily eating tomatoes and tatties for all my life. i won't say what i think about advice like this.

There are two kinds of arthritis and the age-related one shouldn't be linked with food.

Re: New insights into why aspirin works so well

#86

Post by LeoPanthera »

11235813213455 wrote: post #47

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

I'm sure you didn't mean it this way, but this does read as if you're shaming people for using painkillers.

No-one should have to endure pain and there's nothing wrong with the responsible use of drugs to reduce it.

Re: New insights into why aspirin works so well

#87

Post by a_c »

I used to have the impression that the advance of LLM is peak human ignorance - we know how things work in a recipe like fashion, but not why. I even compared this with tribal rituals - follow a recipe with a probably misguided why. News like this gradually make me realize that this is how human wisdom have long been working, discovery and invention first, understanding later.

Re: New insights into why aspirin works so well

#88

Post by 11235813213455 »

LeoPanthera wrote: post #86
11235813213455 wrote: post #47

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

I'm sure you didn't mean it this way, but this does read as if you're shaming people for using painkillers. No-one should have to endure pain and there's nothing wrong with the responsible use of drugs to reduce it.

no, just going in the direction of the article about the fact that drugs for things like inflammation are more counter-productive than useful

Re: New insights into why aspirin works so well

#89

Post by kadoban »

9dev wrote: post #60
11235813213455 wrote: post #47

I use nothing for reducing inflammation, nor any drugs since decades, when I'm ill from time to time (once or twice a year), I let the fever go, the body is just working actively, it's not especially uncomfortable

The body handles inflammations just fine, but you can actively help it to get it done more quickly. Doesn't have to be Aspirin though, chamomile tea and lots of other things work wonders, too.

> The body handles inflammations just fine, but you can actively help it to get it done more quickly.

The body doesn't "handle" inflammations, inflammation is something the body _does itself_ in response to issues.

In the vast majority of cases you don't have to help it do anything, it's intentionally doing that. The only reason to interfere at all is if it's making you uncomfortable or actively causing you problems (the body isn't perfect, it fucks up too).

The same thing applies to fevers. The body doesn't (in the vast majority of cases) need your help getting rid of a fever, it _caused_ a fever because that's part of its immune response. If the fever is becoming dangerous, sure go nuts, but usually you're just reducing its ability to fight off an infection.

Re: New insights into why aspirin works so well

#90

Post by szundi »

a_c wrote: post #87

I used to have the impression that the advance of LLM is peak human ignorance - we know how things work in a recipe like fashion, but not why. I even compared this with tribal rituals - follow a recipe with a probably misguided why. News like this gradually make me realize that this is how human wisdom have long been working, discovery and invention first, understanding later.

Hopefully we realize and reach the off-switch before too late
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