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Psilocybin Produced in Yeast

phys.org

71–80 of 214 posts

Re: Psilocybin Produced in Yeast

#71
Psylocibin is already synthetically available as I understand - its a pill they get in Johns Hopkins trails for smoking cessation. Anyone know how that is produced?

Another point they make is about psylocin. As I understand, as soon as psylocibin hits your stomach acid it gets converted to psylocin anyway. People use lemon to do the process before ingesting in order for it to hit them faster.

Re: Psilocybin Produced in Yeast

#72
post #2

Realistically, I know this will be used to make pills. But the first thing I thought when I saw the headline was, "Wow. That's some interesting beer."

Denmark is in general pretty well known for doing stuff with yeast. The yeast used in most of the worlds lager beer are all "descendants" of a yeast cultivated by the beer company Carlsberg which have been distributed around the world. And the pharma company Nova were among the first to produce human insulin with yeast.

Re: Psilocybin Produced in Yeast

#73
post #18

Earlier quoted context omitted.

> Extraction can’t be that expensive. From the article, apparently yes it can: "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms"

It does say that. It's wrong, what it says, but it definitely says it.

I'd love to hear more about this cheap, efficient extraction of psilocybin from mushrooms.

Re: Psilocybin Produced in Yeast

#74
post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

> There is no reason That psilocybin shouldn’t be administered in its most common form, as it has been for thousands of years They’re using very large doses in therapy, and there are a lot of unpleasant things that are going to happen already even at the minimum effective dose.

It sounded equivalent to 3-4 grams of dried mushrooms, which is a moderately large dose (well that's what they described as a "sweet spot"), but not out of the ordinary. Trips are graded up to level 5 with is > 5g dried. Terrance McKenna talks a lot about 5g in silent darkness.

Re: Psilocybin Produced in Yeast

#75

Earlier quoted context omitted.

It does say that. It's wrong, what it says, but it definitely says it.

Is there any pure psilocybin being sold? My (entirely pop-culture based) impression is that "white powder" and similar processed substances of high purity are the dominant form for almost all drugs. Cocaine isn't sold as leaves, nor can you buy dried poppies. Marijuana is an exception because it easier to smoke in its more natural state and, let's face it, because its users are hippies beholden to the naturalistic fa…

Johns Hopkins trials administer a pill, so I assume it's available somewhere.

Re: Psilocybin Produced in Yeast

#76

Earlier quoted context omitted.

Australia: To use a still of any capacity to distil alcohol such as spirits, you must have an excise manufacturer licence. Severe penalties apply for manufacturing spirits without an excise manufacturer licence. [1] Although, in practice, I can’t say I’ve ever heard of a case of someone being fined for making spirits at home, and you’d probably have to repeatedly offend that particular law in order to be sentenced to…

Isn't that because of taxation? It is that way in Czechia as well, purely because of that; it is OK to make spirits at home though (up to some - albeit pretty large - amount).

Sorry but it is not allowed to make spirits at home in Czech Republic.

You can use certified distillery to make spirit from home grown fruit and pay taxes (although not as much as for commercial alcohol). This spirit is used for personal use only and could not be sold.

Re: Psilocybin Produced in Yeast

#77

Earlier quoted context omitted.

Oh yeah, I forgot about Norway. I have a (Czech) friend there, they have to pull down the sunblinds when they want to drink a beer. Seems insane to me, also a Czech guy.

As a Norwegian I can tell you that your friend is pulling your leg. You are free to drink on private property. I have never heard about anyone being arrested for responsible drinking in public parks, beaches and places like that. It's not allowed to serve people that is "visibly intoxicated" but almost no one cares. At a normal Friday and Saturday night, Oslo is a battlefield of shitfaced people.

Oslo is very liberal when it comes to public drinking. It's not uncommon to get fined for drinking in parks in other cities in Norway. I've only heard of someone getting arrested for it once though, and that was because he refused to pour out the beer when requested by a police officer and chugged it instead.

Re: Psilocybin Produced in Yeast

#78
post #56

Earlier quoted context omitted.

That doesn't sound right. You are allowed to drink beer on your own property, or in bars. You are not allowed to drink beer in public spaces, but the police will enforce that differently depending on the region.

I think it has something to do with them having children.

Drinking with children present is taboo but not illegal. So that kind of makes sense if they have nosy neighbors.

Re: Psilocybin Produced in Yeast

#79
post #51
post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

Standardized total extracts of natural sources are pretty standard in the pharmacopeia, so what you're saying makes total sense. Making sure that the dosage is standardized is a solved problem. Unfortunately this type of drug preparation is not that fashionable. One example of this is the total extract of St. John's Wort, which is superior to synthetic antidepressants in many cases, but doctors often prefer to prescr…

> St. John's Wort, which is superior to synthetic antidepressants in many cases,

Oh boy, yet another claim without references.

Re: Psilocybin Produced in Yeast

#80

Earlier quoted context omitted.

Fair you pointed out but with no implied criticism, those are the exact arguments one should expect from a psilocybin user.

Why is that? Do you think they are less sensical than non-users? Or are you implying that the author was under the influence at the time of writing?

I think that was just a free dunk on drug users. Sorry for being uncharitable here.
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