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Psilocybin Produced in Yeast

phys.org

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Re: Psilocybin Produced in Yeast

#21

Post by edoceo »

ninetax wrote: post #17
mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

Someone more knowledgeable please step in to correct me but: I think what can be desirable from this process is the lack of variability in the product when you produce it at scale.

Grind it, blend it, test it. It's how loads of other naturally variable stuff is done eg: flour, whiskey, wine, juice

Re: Psilocybin Produced in Yeast

#22

Post by rriepe »

mikeg8 wrote: post #9
undersuit wrote: post #7

Earlier quoted context omitted.

Dosing is far easier in pill form regardless?

You can make capsules from ground up mushrooms very easily.

Grinding up a mushroom and putting it in a capsule seems unpredictable, dose-wise.

But a whole batch mixed together? It seems like that would be both testable and predictable. This is the way to go for sure.

Re: Psilocybin Produced in Yeast

#23

Post by rriepe »

chepaslaaa wrote: post #20
karlicoss wrote: post #16

Earlier quoted context omitted.

As far as I understand it's too inconsistent, i.e. very unevenly distributed within one fruiting body. Not sure if that's the reason, but: if you ever bought mushrooms/truffles in the Netherlands, there is no psylocibin content on the box. And if you try googling, the estimates vary pretty wildly (although it's possible that it's just a lack or proper research) Also not everyone enjoys the taste of mushrooms or truff…

With regards to the taste, grinding them up and mixing them into melted chocolate will negate all taste issues (or consistency, I find the getting bits stuck in your teeth is what really sucks).

Nutella is a real blessing here.

Re: Psilocybin Produced in Yeast

#24

Post by 55555 »

rriepe wrote: post #22
mikeg8 wrote: post #9

Earlier quoted context omitted.

You can make capsules from ground up mushrooms very easily.

Grinding up a mushroom and putting it in a capsule seems unpredictable, dose-wise. But a whole batch mixed together? It seems like that would be both testable and predictable. This is the way to go for sure.

From what I remember from 14 years ago when I was more interested in this, psilocybic mushroom strains are, gram-for-gram, almost all equivalent in relative potency.

Drying them to cracker dry, then grinding them up, and encapsulating (optional), is a safe way to dose. It's not unpredictable.

> But a whole batch mixed together

Indeed. This is the right way to do it.

Making it in a test tube is fine, but it's really not needed. Mushrooms are very cheap to grow, and it's not like people need to take big doses daily to get the benefits.

Re: Psilocybin Produced in Yeast

#25

Post by Alex3917 »

mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

> There is no reason That psilocybin shouldn’t be administered in its most common form, as it has been for thousands of years

They’re using very large doses in therapy, and there are a lot of unpleasant things that are going to happen already even at the minimum effective dose.

Re: Psilocybin Produced in Yeast

#26

Post by asdff »

mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

Growing it in yeast would be great if you are trying to get a consistent quantity of the drug. You could do vats at a time all genetically identical and producing the same yield batch over batch, and can scale up and down your operation for as much as you have vats and yeast food.

This is something you want if you are going to press this into pills at a certain dose and give to people for psychiatric disorders, not for people looking to go on spiritual journeys or see a phish concert.

Re: Psilocybin Produced in Yeast

#27

Post by [deleted] »

mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

[deleted]

Re: Psilocybin Produced in Yeast

#28

Post by asdff »

55555 wrote: post #24
rriepe wrote: post #22

Earlier quoted context omitted.

Grinding up a mushroom and putting it in a capsule seems unpredictable, dose-wise. But a whole batch mixed together? It seems like that would be both testable and predictable. This is the way to go for sure.

From what I remember from 14 years ago when I was more interested in this, psilocybic mushroom strains are, gram-for-gram, almost all equivalent in relative potency. Drying them to cracker dry, then grinding them up, and encapsulating (optional), is a safe way to dose. It's not unpredictable. > But a whole batch mixed together Indeed. This is the right way to do it. Making it in a test tube is fine, but it's really n…

mushrooms aren't as cheap to grow as laboratory yeast cultures already set up to produce quantities of drug of interest.

Re: Psilocybin Produced in Yeast

#30

Post by derefr »

scythe wrote: post #8

Psilocybin may be an underrated chemical precursor. 4-substituted indoles are notoriously difficult to synthesize. Psilocin is a rare example of a natural one. (LSD is another.) For example, a milliliter of 4-bromoindole costs a whopping $75: https://www.sigmaaldrich.com/catalog/product/aldrich/524336?... Presumably this technique could produce psilocybin for much less than $75 per milliliter.

Are you sure that these precursors aren't just expensive because so many of the compounds that go into them, or which come from them, are controlled substances?

There are a lot of bulk reactants that I'd like to buy for chemistry experiments, but can't (because they're controlled, because they can be used to make illegal things), so I have to make them myself from even earlier precursor chemicals; this adds (via labor costs) to the cost of making the final product. Presumably, even big producers like Sigma are in the same situation.

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