51–60 of 211 posts
no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird
In theory you could supplement with L-tryptophan which is metabolized into indole which then raises GLP-1 production within enteroendocrine cells. https://www.sciencedirect.com/science/article/pii/S221112471...
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
When the side effects are better understood I suspect for the average person, eating less would be a net benefit to their overall health - _even if they don't lose any weight_.
no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird
In theory you could supplement with L-tryptophan which is metabolized into indole which then raises GLP-1 production within enteroendocrine cells. https://www.sciencedirect.com/science/article/pii/S221112471...
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
Some people stop using it due to personality changes.
I've gained about 15-20 pounds back, but I'm now much healthier overall.
I like how my brain works and I didn't like something affecting or changing that because I couldn't put the fork down. Easy decision for me
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[1] https://link.springer.com/article/10.1007/s12672-025-03902-4
no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird
In theory you could supplement with L-tryptophan which is metabolized into indole which then raises GLP-1 production within enteroendocrine cells. https://www.sciencedirect.com/science/article/pii/S221112471...
> Indole increased GLP-1 release during short exposures, but it reduced secretion over longer periods.
> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong…
Yeah, most GLP-1 benefits (or even adverse effects, like muscle loss) seem to be caused by the weight loss. We already knew obesity massively increases risk from a host of diseases, but GLP-1s are still treated with scepticism of the "oh but what about the side-effects we don't know about?!" variety?
There’s growing evidence of cardioprotective effects independent of weight loss.
Eg https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
> The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss and had only a small association with waist circumference, suggesting some mechanisms for benefit beyond adiposity reduction.