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GLP-1 drugs linked to lower death rates in colon cancer patients

today.ucsd.edu

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#41

Post by stavros »

jl6 wrote: post #22

> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong…

Yeah, most GLP-1 benefits (or even adverse effects, like muscle loss) seem to be caused by the weight loss. We already knew obesity massively increases risk from a host of diseases, but GLP-1s are still treated with scepticism of the "oh but what about the side-effects we don't know about?!" variety?

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#43

Post by robbomacrae »

azinman2 wrote: post #33
robbomacrae wrote: post #4

Earlier quoted context omitted.

There have been some. I've heard about eyesight related issues. A quick google found this article [0] where results showed that people using GLP-1 drugs were 68.6 times more likely to develop certain types of vision problems. [0]: https://www.aao.org/newsroom/news-releases/detail/do-glp-1-d...

This is also an extremely rare vision problem. So absolute numbers are very tiny. The absolute numbers for diabetes, weight related problems, etc far dwarf this.

Right. On the whole I think these things are incredible.. looking to try myself after reading here in HN the other day about it working for all sorts of distractions. Just wanted to point out it's not all sunshine and rainbows which would certainly be suspicious.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#44

Post by stavros »

daedrdev wrote: post #38
cerved wrote: post #34

Earlier quoted context omitted.

Well glp1 doesn't make you want to eat broccoli. Just less in general

sure but it definitely makes carbs specifically disgusting in my case

I can confirm that. On GLP-1s (when they worked for me, anyway), I'd routinely think "pizza? Bleh, so fatty, I'd really like some chicken breast with roast potatoes instead right now".

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#46

Post by stavros »

OptionOfT wrote: post #11
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Even with an increased risk of mortality, at least right now I can live. The voice in my head that is constantly telling me I'm hungry is quiet. Without it I'd die sooner anyway.

It's not even "I'm hungry", it's just "must have more food". What a nuisance.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#47

Post by degamad »

bpodgursky wrote: post #5
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

GLP-1s are just showing what people always knew to be true but was not clinically actionable — most of our health problems come from eating too much and being fat. Well, now it's actionable. No magic, just adherence.

We don't quite have the data to say "most" yet, but it's certainly looking like "many" is justifiable.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#48

Post by JumpCrisscross »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

> I'm waiting for the other shoe to drop when it comes to GLP-1s

We know there are downsides. They’re just irrelevant compared to being obese. (Or alcoholic. Or, potentially, overweight.)

It might be a vitamin, where there literally aren’t any downsides. I’m sceptical of that. But to the degree there is mass cognitive bias in respect of GLP-1s, it’s against them. (I suspect these are sour grapes due to the drugs being unreachable for many.)

My frank concern is we’re separating into a social media addicted, unvaccinated and obese population on one hand and a wealthy, insured, disease free and fit one on the other. Those are dangerous class and physical divides to risk becoming heritable (socially, not genetically).

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#49

Post by matthewdgreen »

gwbas1c wrote: post #7
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Some people stop using it due to personality changes.

Say more?

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#50

Post by [deleted] »

azinman2 wrote: post #33
robbomacrae wrote: post #4

Earlier quoted context omitted.

There have been some. I've heard about eyesight related issues. A quick google found this article [0] where results showed that people using GLP-1 drugs were 68.6 times more likely to develop certain types of vision problems. [0]: https://www.aao.org/newsroom/news-releases/detail/do-glp-1-d...

This is also an extremely rare vision problem. So absolute numbers are very tiny. The absolute numbers for diabetes, weight related problems, etc far dwarf this.

[deleted]
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