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New‐onset autoimmune phenomena post‐Covid‐19 vaccination

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Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#51
post #18

This is a pretty non-controversial paper and doesn't contain anything shocking or previously unknown, but the title has the potential to cause controversy. Here's my quick summary: - Previous vaccines for HPV, Hepatitis B and Flu are known to (rarely) trigger or worsen autoimmune diseases such as Guillain-Barré syndrome. - Lots of new Covid vaccines have been created globally using a wide variety of technologies (mRN…

Nice summary - with apologies I’ll nitpick - I am not aware of VITTP from mRNA vaccines. (Edit - I dial this back - I see the piece in the paper where they mention the case series from mRNA vaccines) I think (I guess the audience of a scientific paper is more general a scientific audience) that it would be nice if there was at least a comparator paragraph to the risks of actual COVID disease. Molecular mimicry is to…

> rise in both type 1 and type 2 diabetes in those less than 18 with a recent COVID infection

https://twitter.com/j_g_allen/status/1479876564930248708

> Careful with this study on diabetes. Worth skipping ahead to the limitations section…

  1. Single ICD code
  2. Differential exposure misclassification
  3. No covariates (obesity?!)
  4. only included those seeking care + insured 
> (actually a great teaching case for EPI 101!)

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#52
post #28

Earlier quoted context omitted.

Well I’m taking a stand against the anecdote then

> Well I’m taking a stand against the anecdote then I am not generalising, just providing a single data point about my local health service which is very relevant to my treatment. Even if it an outlier or does not match your colleagues experiences it does not make it less true for me. I recommend reading the top comment by walterbell. Not everything is an attack on medicine/science. While it's important to keep discu…

If you read my comment you will see that it is not, in fact an attack on you and if I had not made the unfortunate use of the word ‘claim’ and instead said ‘I’d like to counter your anecdote with one of my own …… and lets wait until there’s more data’ then we wouldn’t be having this thread. As it stands I apologise and also retract my snappy comment that you are replying to above.

The problem with anecdote, whichever way you cut it, particularly in a charged debate like this, is that they get picked up and snowball just like the election being stolen. People believe them, even if there is no data. Now we can’t wait until the data is in in every circumstance particularly in a public health crisis. So it’s appropriate to try and inform, listen to the stories, and do the studies, and also recognise that when you try and give some new medication to billions of people there’s bound to be some blowback. But how much? To what degree? And are we communicating the issues in a truthful, timely and non-alarmist manner?

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#53
post #45
post #37

Earlier quoted context omitted.

Yes, that’s my doubt as well. Until we have more unbiased studies coming out, we can’t determine the impact of these side effects. The problem with pro-vaccine propaganda is that it tells you to blindly listen to the science. The problem with that is “the science” is controlled by commercial interests and profit margins. It’s like telling everyone democracy is the One True Way and we end up in last-stage capitalism.

Well - I’m not sure I have doubts but I remain open to the possibility. As a doctor and public health advocate I think the vaccines are miracles and have saved already millions of lives. Our society is already fundamentally changed by the damage wrought by the virus. There are over 140,000 ORPHANS that have been created by COVID in the last 2 years in the US alone [0]. The vaccine is safe and effective, if unfortunat…

You wrote a very long reply, but didn’t really address my argument directly. I am fully vaccinated, but I’m not blind to capitalistic interests and corruption.

The “science” in this case are vaccines produced by pharmaceutical corporations that have the ability to dictate that developing countries pledge their sovereign assets to cover their exorbitant pricing. (1) All vaccine companies are fighting over patents and ownership. And there’s innumerable other scandals. (2)

You appear to trust authorities way more than I do, so we probably won’t ever see eye to eye on this.

(1) https://www.fdanews.com/articles/202403-pfizer-stops-demandi...

(2) https://www.transparency.org/en/press/covid-19-vaccines-lack...

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#54
post #37
post #32

Earlier quoted context omitted.

But they aren’t in the same magnitude - for example, incidences of peri/myocarditis is 30x (at a minimum) greater in someone who has COVID vs someone vaccinated; and vaccination leads to shorter milder breakthrough infections which (should - I can’t claim to have seen a study) lead to a lower incidence compared to someone who was unvaccinated and infected

Yes, that’s my doubt as well. Until we have more unbiased studies coming out, we can’t determine the impact of these side effects. The problem with pro-vaccine propaganda is that it tells you to blindly listen to the science. The problem with that is “the science” is controlled by commercial interests and profit margins. It’s like telling everyone democracy is the One True Way and we end up in last-stage capitalism.

@robbiep wasn't agreeing with you.

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#55

I wish we could have a disclaimer on every article/study about vaccine side effects, something like: "This is not an attack on vaccines, pharmaceutical interventions, associated stakeholders or policy makers. This is not a statistical assessment of risk for specific audiences. Please focus feedback and resources on specific treatments for the living human beings who have been injured. Even one in a million is of litt…

Thanks you for this thoughtful response. I chose to be vaccinated and unfortunately have suffered serious consequences like a very small number of other people will statistically. It's been pretty disheartening to see that sharing anything negative about vaccines, even those warned about by medical officials, leads to very negative reactions from people (being told to shut up, being censored/downvoted online etc). I…

This saddens me greatly.

I'm continually amazed at the arrogant, ignorant, and down right "head in the sand" nature that has swept across the minds of the land. Worse is that "their thoughts are not theirs". They are being taught to hate you because your truth is inconvenient.

I wish you the best recovery possible.

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#56
post #37

Earlier quoted context omitted.

Yes, that’s my doubt as well. Until we have more unbiased studies coming out, we can’t determine the impact of these side effects. The problem with pro-vaccine propaganda is that it tells you to blindly listen to the science. The problem with that is “the science” is controlled by commercial interests and profit margins. It’s like telling everyone democracy is the One True Way and we end up in last-stage capitalism.

> The problem with that is “the science” is controlled by commercial interests and profit margins. Is it? A good proportion of academia is funded by states, non-profits, and tuition from undergraduate students, and researchers generally operate with a great degree of autonomy. Of course there is corrupt research out there, but I see little evidence that it's pervasive.

I don’t think it’s reasonable to live in 2022 and argue that academia isn’t influenced by capitalistic interests. This is so backwards of a viewpoint that I don’t have the time to argue further.

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#57
post #35
post #29

Earlier quoted context omitted.

Ok, but if I get vaccines I’m exposed, but may not be exposed to Covid or at least a variant that causes an immune disorder.

You’re at a 30x (minimum) increased risk, as well as running a 0.5-2% chance of dying depending on your state of health. If you’re less than 18, you have a higher risk of type 1 OR type 2 diabetes. Anyone who willingly runs that risk in the light of a (let’s face it, extremely safe) alternative is making some sort of strange calculus that is not in any way rational

Source for 30x risk of autoimmune disorder?

And no, the floor of fatality is not 0.5%, you’re off by an order of magnitude (too high) at least.

And source for risk of diabetes.

You’re throwing a lot of “facts” around that don’t seem to be true.

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#58
post #29

Earlier quoted context omitted.

Ok, but if I get vaccines I’m exposed, but may not be exposed to Covid or at least a variant that causes an immune disorder.

Unless you're planning to isolate at home indefinitely or live somewhere very remote you are pretty much guaranteed to be exposed to covid at some point. A good proportion of my friends have already had it twice. Consider that Omicron is more infectious than the common cold and how many colds you've had in your life. The main risk factor in whether you develop an auto-immune disorder (other than the specifics of your…

Sure, I might be exposed in the next few years, but that variant may be very different than current ones.

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#59
post #33

This is a pretty non-controversial paper and doesn't contain anything shocking or previously unknown, but the title has the potential to cause controversy. Here's my quick summary: - Previous vaccines for HPV, Hepatitis B and Flu are known to (rarely) trigger or worsen autoimmune diseases such as Guillain-Barré syndrome. - Lots of new Covid vaccines have been created globally using a wide variety of technologies (mRN…

The main problem I have with all these papers is that they don't compare to the rates of symptoms from having had Covid . A lot of the idiocy these kinds of papers cause would be muted if you could point at the paper and say "Probably of X from vaccine--N%. Probability of X from Covid--N+M%." Of course, if the probability of X is less than with Covid--that's important to know, as well. It defines which vaccines we sh…

> “Probably of X from vaccine--N%. Probability of X from Covid--N+M%."

It’s always important to do the math. But you’ve missed the third, and most obvious, calculation.

Probability of X from vaccine+Covid — 2N+M, or whatever.

Re: New‐onset autoimmune phenomena post‐Covid‐19 vaccination

#60
post #18

Earlier quoted context omitted.

Nice summary - with apologies I’ll nitpick - I am not aware of VITTP from mRNA vaccines. (Edit - I dial this back - I see the piece in the paper where they mention the case series from mRNA vaccines) I think (I guess the audience of a scientific paper is more general a scientific audience) that it would be nice if there was at least a comparator paragraph to the risks of actual COVID disease. Molecular mimicry is to…

> rise in both type 1 and type 2 diabetes in those less than 18 with a recent COVID infection https://twitter.com/j_g_allen/status/1479876564930248708 > Careful with this study on diabetes. Worth skipping ahead to the limitations section… 1. Single ICD code 2. Differential exposure misclassification 3. No covariates (obesity?!) 4. only included those seeking care + insured > (actually a great teaching case for EPI 10…

Thank you
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