Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

What Ozempic does to the gut-brain axis

psychologytoday.com

Post reply on HN
Print view View original

451–460 of 555 posts

Re: What Ozempic does to the gut-brain axis

#451

Post by owebmaster »

faangguyindia wrote: post #350
tsimionescu wrote: post #337

Earlier quoted context omitted.

Because you're feeling peckish. Because you hadn't had a good burger in a while. Because you saw a good looking pizza on TV and you can't order less than a full pizza. Because your mother made this good lasagna and would feel offended if you didn't eat a portion because you'd already eaten earlier. Because you're sadand tired and just don't want to also feel hungry, and eating a pack of oreos dipped in nutella is mor…

Never had this issue tbh, I maintain 12% bodyfat year around and cannot relate to people who just eat when there is no need to eat.

Just post less in this thread then? People got your point already.

Re: What Ozempic does to the gut-brain axis

#452

Post by SoftTalker »

habinero wrote: post #341
SoftTalker wrote: post #222

Earlier quoted context omitted.

Buy unprocessed food and prepare it yourself. Don't add sugar. Eating processed food and even most restaurant food is eating food that's designed to make you want more, not satiate you.

Yeah, that does nothing. I love to cook, and I can cook super healthy and like it. I'm still hungry lol. There's a part of my brain that constantly thinks about food. It's like tinnitus. GLPs stopped that cold.

Do you have addictive/compulsive tendencies in other things besides eating? Did GLPs reduce those as well (I've heard that it does)?

For me, stopping fast food, most restaurant/takeout food, and processed food such as bread, pastries, chips, cookies, and any prepared/convenient "snack" items drastically reduced how often I felt hungry or just wanted to eat for no apparent reason.

Re: What Ozempic does to the gut-brain axis

#453

Post by topgrain2 »

hack1312 wrote: post #269
topgrain2 wrote: post #246

Earlier quoted context omitted.

The drug is more likely to work long-term. Diet & exercise, as a treatment plan, are distressingly ineffective. Well-studied problem. It makes more sense when you realize that something like sheer dieting/exercising willpower isn't why some populations are skinnier than others. Pick another country with a healthier-weight population, start placing some of them in the US, and they'll gain weight. Put them back, and it…

So clearly it’s something to do with the difference in their lives in the USA, but your first response is to treat the symptom with drugs rather than look at their life holistically? Just off the top of my head the food (portions, quality, etc) in the USA combined with how much people no longer can walk vs being required to drive are a huge contributor to weight gain of immigrants to the USA.

A person can take a shot every week.

What’s a person supposed to do about a problem that’s probably tangled up in several major areas and would require large reforms across the economy? We can’t even get mandatory minimum paid leave or healthcare for everyone (both of which might well be components of fixing it “right” anyway!)

This is likely a problem that spans our food culture, business culture, economic structure, built geography, and social benefits system, among other things.

You can spend a lifetime fighting those and be fat the whole time because despite massive effort and objectively incredible achievements you and your movement only got us 5% (that’s a lot!) down the road towards fixing these things, in fifty years.

Or you can take a weekly shot and be well on your way in a month.

Working on the “real” fix is definitely something we should do (it’s not like the causes of this aren’t causing other things to suck, too) but even people doing that would probably like something available that they, not just their great-grandchildren, can have.

Re: What Ozempic does to the gut-brain axis

#454

Post by fooker »

spicyusername wrote: post #425
wpm wrote: post #21

Earlier quoted context omitted.

Why not? People take depression meds, blood pressure meds, all kinds of meds for their whole life. I'll be on omeprazole for reflux my whole life. It doesn't solve the underlying problem of my gut being prone to overpumping acid into my stomach. So omeprazole is problematic? The underlying issue is being treated, it's treated by taking the drug. It works. It's doing its job. I'd be curious as to how you came to this…

Because it's pretty likely some of these have negative long term effects. And some of those long-term effects are probably pretty serious. Many people taking these kind of drugs are gambling with their well being. No doubt that in many cases that gamble is worth it. But issues that can be solved with non-pharmaceutical solutions, such as with weight loss and lifestyle changes, are really better solved that way if pos…

The negative long term effects are unlikely to be worse than the negative long term effects of obesity.

Re: What Ozempic does to the gut-brain axis

#455

Post by unparagoned »

mycall wrote: post #265
ceejayoz wrote: post #152

Earlier quoted context omitted.

What if you could intentionally eat good food? I've heard it widely described as reducing mental noise around food.

People can get fat by eating too much healthy food.

Not really the fiber and stuff is normally too filling

Re: What Ozempic does to the gut-brain axis

#456

Post by SoftTalker »

thesmtsolver2 wrote: post #279
SoftTalker wrote: post #213

Earlier quoted context omitted.

But that's not what the pharma companies want. They want you on the lifetime prescriptions that don't actually address the underlying problem.

Are they hiding true solutions treating the underlying issues?

I don't think they are hiding true solutions but they are not pursuing them.

Their R&D is directed at treating common chronic conditions with drugs that you have to take forever. That's what makes them money. Treatments for rare conditions or true solutions do not. It's just economic incentives.

That's also why when they do develop something for a rare condition, it costs you a bankrupting amount of money if you need it.

Re: What Ozempic does to the gut-brain axis

#457

Post by unparagoned »

Bombthecat wrote: post #372
mycall wrote: post #265

Earlier quoted context omitted.

People can get fat by eating too much healthy food.

Wasn't there just a study, that many fat kids are fat because of fruit juices? Healthy in a way, but surprisingly a lot of sugar ( either added or from the fruits)

Fruit juice isn’t considered healthy. It has worse health outcomes than soda

Re: What Ozempic does to the gut-brain axis

#458

Post by unparagoned »

chiply314 wrote: post #365
Illotus wrote: post #359

Earlier quoted context omitted.

8 to 10 oranges per day being healthy or not is largely dependent what else you eat. Biggest issue there is likely teeth decay due to acidity.

No its not. 8-10 Oranges is too much sugar. Too much sugar hurts your insulin reaction and can bring diabetes.

No with the fiber that’s perfectly fine. The slow release of sugar is perfectly fine. Obesity is the main risk for insulin, fast release sugar is bad for insulin via obesity not on its own.

Re: What Ozempic does to the gut-brain axis

#459

Post by unparagoned »

s1artibartfast wrote: post #319
faangguyindia wrote: post #275

Earlier quoted context omitted.

true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense. Eating healthy food alone isn't solution, you need to make your life active as well.

This has never been my problem. I can easily eat 5k calories of whole foods

Healthy and whole foods are a different thing. A healthy diet would have so much fiber that 5k Fritos be near impossible

Re: What Ozempic does to the gut-brain axis

#460

Post by faangguyindia »

theshrike79 wrote: post #389
faangguyindia wrote: post #352

Earlier quoted context omitted.

[flagged]

People are different. Weird, right? I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it". I'm not like that. Leaving half a burger that I paid for on the plate is something I've never done or even conside…

>People are different. Weird, right?

How many people you see with 3 eyes and 4 on regular basis to claim people are different? I'd argue most people aren't that different.

Calorie balance works for majority of people.

>I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".

Here's a thing, most of the underweight people tell me they are genetically predisposed to not gaining weight. When I calculate calories in their regular diet, what I notice is a very low-calorie diet.

After that, I put them on calorie-dense shakes and high-intensity workouts, with light movement, and their appetite quickly starts growing as they start consuming healthy fats.

The same engine which starts this appetite can also have a "thermal runway" kind of mechanism where your appetite just becomes very large and it becomes harder to dial down.

The question is why reach that point?

Post reply on HN