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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#341

Post by habinero »

SoftTalker wrote: post #222
mynameisash wrote: post #209

Earlier quoted context omitted.

What breaks the hunger response, and how does one fix it? Maybe it's well-known, but I read the starvation response Wikipedia page[0] and didn't grok it. [0] https://en.wikipedia.org/wiki/Starvation_response

Buy unprocessed food and prepare it yourself. Don't add sugar. Eating processed food and even most restaurant food is eating food that's designed to make you want more, not satiate you.

Yeah, that does nothing. I love to cook, and I can cook super healthy and like it. I'm still hungry lol.

There's a part of my brain that constantly thinks about food. It's like tinnitus. GLPs stopped that cold.

Re: What Ozempic does to the gut-brain axis

#342

Post by crooked-v »

TMWNN wrote: post #277

The more I hear about GLP-1 drugs, the more I think there is something to the joking suggestion of putting it in the water supply.

I personally think that once the patents expire, it will be about as universal as antihistamines, or if not, only because of the larger side effects like rapid weight loss causing gallstones.

Re: What Ozempic does to the gut-brain axis

#343

Post by herbst »

wpm wrote: post #21
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

Why not? People take depression meds, blood pressure meds, all kinds of meds for their whole life. I'll be on omeprazole for reflux my whole life. It doesn't solve the underlying problem of my gut being prone to overpumping acid into my stomach. So omeprazole is problematic? The underlying issue is being treated, it's treated by taking the drug. It works. It's doing its job. I'd be curious as to how you came to this…

I know several people who stopped both of your examples and only used them for a while until the underlaying issues got fixed. I am just in the progress of stopping with anti depression meds. Without bigger issues.

Maybe in America you do, here in Europe I am not so sure about that

Re: What Ozempic does to the gut-brain axis

#344

Post by herbst »

crooked-v wrote: post #154
htk wrote: post #150

Earlier quoted context omitted.

No, the symptom is being treated, not the underlying issue. And that's ok, but treating the underlying issue, when possible, is better, as the problem ceases to exist.

For many people, the "underlying issue" is fundamentally just being too hungry for how they live. GLP-1s absolutely treat that.

Sounds like they eat the wrong things. So learning to eat properly and stopping with GLP after a while sounds more reasonable to me.

Also that's how my mum got it in the swiss test run. It was never supposed to be long term, just to help change eating habits.

Re: What Ozempic does to the gut-brain axis

#345

Post by shlant »

brazukadev wrote: post #43
vidarh wrote: post #29

Earlier quoted context omitted.

Given that we know that diets and changing habits doesn't have lasting effects, what doesn't sit well with me is to risk my health to avoid taking a drug that helps.

changing habits do have lasting effects, I'm not part of this "we" that doesn't know that.

they have long lasting effects if the changes are long lasting. Almost never the case

Re: What Ozempic does to the gut-brain axis

#346

Post by shlant »

JumpCrisscross wrote: post #97
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

> almost all subjects regained the weight and reversed gains within 2 years Source? I thought it was 2/3rds of the weight regained, which is still a substantial long-term loss.

supposedly that comes mostly from observational studies whereas RCT's seem to show that at some point full regain will probably happen (although can take 1-2 years). The Observational studies don't seem to control for people stopping GLP-1's but still trying other drugs/weight loss methods which is where the discrepancy from RCT's seems to be.

Re: What Ozempic does to the gut-brain axis

#347

Post by shlant »

incognito124 wrote: post #66
sph wrote: post #44

Earlier quoted context omitted.

Very weird (or funny?) to use statins as an example of a ‘good and effective’ drug.

Why do you say that? My first exposure to statins was in https://myticker.com and they seem somewhat important

the vast majority of the anti-statin crowd are just regurgitating talking points they heard from people in their diet tribe - usually keto/carnivore

Re: What Ozempic does to the gut-brain axis

#349

Post by fouc »

mycall wrote: post #265
ceejayoz wrote: post #152

Earlier quoted context omitted.

What if you could intentionally eat good food? I've heard it widely described as reducing mental noise around food.

People can get fat by eating too much healthy food.

I think there's a bit of a caveat there, because that basically means eating reasonably high calorie food in sufficient quantities that starts violating the "healthy food" definition.

Re: What Ozempic does to the gut-brain axis

#350

Post by faangguyindia »

tsimionescu wrote: post #337
faangguyindia wrote: post #258

Earlier quoted context omitted.

If you are eating 2700kcal a day which is what an average male probably eats in West Why would you eat 2700+800 = 3500kcal? when you can do with 2700kcal?

Because you're feeling peckish. Because you hadn't had a good burger in a while. Because you saw a good looking pizza on TV and you can't order less than a full pizza. Because your mother made this good lasagna and would feel offended if you didn't eat a portion because you'd already eaten earlier. Because you're sadand tired and just don't want to also feel hungry, and eating a pack of oreos dipped in nutella is mor…

Never had this issue tbh, I maintain 12% bodyfat year around and cannot relate to people who just eat when there is no need to eat.
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