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FDA approves new ADHD drug for children

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Re: FDA approves new ADHD drug for children

#42
post #22

Earlier quoted context omitted.

None of you ever want to hear it, but everyone goes through this. It’s the human condition. I’m an addict, and I’ve just justified with Herculean levels of mental gymnastics to keep abusing drugs/alcohol. There’s nothing you can say to me, I will convince myself it’s fine. Edit: I spent most of my youth playing video games for 5+ hours daily. I had zero work ethic. It caught up to me and I worked hard to fix it, and…

> None of you ever want to hear it, but everyone goes through this. It’s the human condition. Comments like this make me angry because it shows how much of a disconnect there is with taking ADHD serious. It's like saying to a depressed person to "just don't be sad and focus on something fun". Sure everyone struggles, but imagine those struggles cranked up by 20x. You overthink EVERYTHING, you're driven by random impu…

>Sure everyone struggles, but imagine those struggles cranked up by 20x. You overthink EVERYTHING, you're driven by random impulses that make you focus on something new and shiny, that make you yourself believe that this is not an impulsive, but this time something worth committed to it, just to lose interest 2 weeks later.

I'm still having a hard time seeing this as a debilitating condition, I can relate to all the things you said and undoubtably taking drugs like modafinil or ritalin turn me super productive and focused, but I don't want to be medicating day in day out, tolerance grows too fast.

End of the day responsibilities forced me to stick with things after I lose interest, sure I may be 20% as productive as I would be if I was super interested and I spend 80% of the time distracted because I'm bored, but 100% is usually 5x of what people consider the norm anyway.

Re: FDA approves new ADHD drug for children

#43

ADHD, diabetes, depression, anxiety, heart disease, suicide and obesity are all labels for defects of human physiology that exist or come to exist from sitting and focusing on one thing (usually alone) for long periods of time. Labeling in this way has the funny consequence of taking onus off the societal arrangement that creates these conditions. I wonder, is this an active discussion in the medical community? The e…

ADHD isn’t a modern malady. It’s been around for centuries. Just under different names.

Here’s a reference from the 400’s BC: He [Hippocrates] was known to have made at least one reference to some patients who could not keep their focus on any one thing for long and had exceptionally quick reactions to things around them. He thought the cause was an “overbalance of fire over water” and recommended a bland diet that included fish but little other meat, a lot of water, and lots of physical exercise.

Re: FDA approves new ADHD drug for children

#44
post #23

Earlier quoted context omitted.

It's weird right, because the experience _is_ something everyone goes through but for adhd individuals it is more difficult in a way that's quantifiably describable but difficult to quantitatively convey

It’s called ‘inability to accept that you need to actually put more effort into things, and it’s not going to be fun’. Again, been there, done that. What is one of the classic bullshit things about it again, you can ‘hyperfocus’ on things you like but can’t on things you don’t like. Gosh. Yeah that’s everyone, and everyone sucks it up and finds a way to deal with it.

Go in with and open mind and read this article https://gekk.info/articles/adhd.html

Re: FDA approves new ADHD drug for children

#45

For anyone curious about the proposed mechanism of action, care of the Wikipedia page https://en.wikipedia.org/wiki/Viloxazine > Viloxazine, like imipramine, inhibited norepinephrine reuptake in the hearts of rats and mice; unlike imipramine, it did not block reuptake of norepinephrine in either the medullae or the hypothalami of rats. As for serotonin, while its reuptake inhibition was comparable to that of desipram…

I found this very informative: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473988/

It seems to increase 5-HT by 500% (as well as NE and dopamine) in the prefrontal cortex. This hopefully makes it more effective than the other pure NRIs that have been used for ADHD.

The fact that it has less of a cardiovascular impact than a classical NRI or stimulant is neat as well.

Re: FDA approves new ADHD drug for children

#46
post #22

Earlier quoted context omitted.

> None of you ever want to hear it, but everyone goes through this. It’s the human condition. Comments like this make me angry because it shows how much of a disconnect there is with taking ADHD serious. It's like saying to a depressed person to "just don't be sad and focus on something fun". Sure everyone struggles, but imagine those struggles cranked up by 20x. You overthink EVERYTHING, you're driven by random impu…

>Sure everyone struggles, but imagine those struggles cranked up by 20x. You overthink EVERYTHING, you're driven by random impulses that make you focus on something new and shiny, that make you yourself believe that this is not an impulsive, but this time something worth committed to it, just to lose interest 2 weeks later. I'm still having a hard time seeing this as a debilitating condition, I can relate to all the…

Think of the relation between being really sad and having crippling depression.

Now take “occasional ADHD symptoms” and ramp them up to the same degree. Get an idea of how this could be debilitating now?

Re: FDA approves new ADHD drug for children

#47

Seems that lots of people only think ADHD people have a hard time paying attention. If it was that simple I would be so happy. Here are just a few of the things I struggle with. - Will power. People with ADHD struggle sooooo much with will power. It’s a constant struggle with everything in life and really wears you down. - Constantly putting on a fake front pretending you don’t have ADHD. - Rejection sensitivity - Fe…

None of you ever want to hear it, but everyone goes through this. It’s the human condition. I’m an addict, and I’ve just justified with Herculean levels of mental gymnastics to keep abusing drugs/alcohol. There’s nothing you can say to me, I will convince myself it’s fine. Edit: I spent most of my youth playing video games for 5+ hours daily. I had zero work ethic. It caught up to me and I worked hard to fix it, and…

Everyone goes through this. You’re right. That’s why we have fairly common language for the experience. It’s human to feel all of these symptoms to some extent at some times. The differences are that the experience is debilitating for people with ADHD, much more frequent or omnipresent, and actually leads to substance abuse when untreated.

We’re not justifying anything. We want to be more well. Proper diagnosis, treatment and recognition helps with that.

Re: FDA approves new ADHD drug for children

#48
post #23

Earlier quoted context omitted.

It's weird right, because the experience _is_ something everyone goes through but for adhd individuals it is more difficult in a way that's quantifiably describable but difficult to quantitatively convey

It’s called ‘inability to accept that you need to actually put more effort into things, and it’s not going to be fun’. Again, been there, done that. What is one of the classic bullshit things about it again, you can ‘hyperfocus’ on things you like but can’t on things you don’t like. Gosh. Yeah that’s everyone, and everyone sucks it up and finds a way to deal with it.

One of the actual bullshit things about ADHD is that I often can't focus even on things I do like. Absolutely nothing convenient about that.

Re: FDA approves new ADHD drug for children

#49

Earlier quoted context omitted.

>Sure everyone struggles, but imagine those struggles cranked up by 20x. You overthink EVERYTHING, you're driven by random impulses that make you focus on something new and shiny, that make you yourself believe that this is not an impulsive, but this time something worth committed to it, just to lose interest 2 weeks later. I'm still having a hard time seeing this as a debilitating condition, I can relate to all the…

Think of the relation between being really sad and having crippling depression. Now take “occasional ADHD symptoms” and ramp them up to the same degree. Get an idea of how this could be debilitating now?

Yep - but from what I've seen in kids diagnosed as ADHD it's not really close, my nephew got diagnosed but realistically I can see myself being way worse at his age and still coming out functional without medication.

Re: FDA approves new ADHD drug for children

#50
post #36

ADHD, diabetes, depression, anxiety, heart disease, suicide and obesity are all labels for defects of human physiology that exist or come to exist from sitting and focusing on one thing (usually alone) for long periods of time. Labeling in this way has the funny consequence of taking onus off the societal arrangement that creates these conditions. I wonder, is this an active discussion in the medical community? The e…

ADHD is not a in the same class as “defects of human physiology that exist or come to exist from sitting and focusing on one thing (usually alone) for long periods of time.” Here is a better definition: ADHD represents the extreme end of the distribution of several highly correlated normal traits in the human population, just like intelligence. In this case, these are inattention (specifically distractibility, poor p…

We have partially lizard brains that evolved for running distances to pack hunt. If your expectations are that we should all be able to sit for 8-10 hours a day from the time we're children, it's easy to say some percent of us have a defect. The defect -- to me -- doesn't seem to be that some percent of our lizard brains can't do that. It seems to be in our expectations.
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