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FDA approves new ADHD drug for children

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Re: FDA approves new ADHD drug for children

#11

Post by lazide »

Someone1234 wrote: post #8
alea_iacta_est wrote: post #5

We normalize our children behavior with pills while celebrating diversity in adults. Interesting times...

Do people "celebrate" ADHD-like dysfunction in adults? Seems like a lot of adults struggle substantially with those issues (in particular without a diagnosis).

If you overlap Elon Musks behavior (or a number of quite famous musicians) with ADHD diagnosis charts, you’re going to have a fun time.

Like most things, we celebrate the high functioning folks and denigrate those who aren’t. Kids are also expected to fall in line and be easy to manage, and those that aren’t get medicated.

Re: FDA approves new ADHD drug for children

#14

Post by dvcrn »

PragmaticPulp wrote: post #3

For anyone curious about the proposed mechanism of action, care of the Wikipedia page https://en.wikipedia.org/wiki/Viloxazine > Viloxazine, like imipramine, inhibited norepinephrine reuptake in the hearts of rats and mice; unlike imipramine, it did not block reuptake of norepinephrine in either the medullae or the hypothalami of rats. As for serotonin, while its reuptake inhibition was comparable to that of desipram…

Reads a bit like Strattera/Atomoxetine with some mild GABA-effects? Although up-regulating GABA-B doesn't sound great in the long run

> More recent research has found that the mechanism of action of viloxazine may be more complex than previously assumed.[12] It appears to act as a potent antagonist of 5-HT2B receptors and as a potent agonist of 5-HT2C receptors.[12] These actions may be involved in its effectiveness for ADHD.[12]

This line here is interesting though. Curious to see where this research is going

Re: FDA approves new ADHD drug for children

#15

Post by lazide »

PragmaticPulp wrote: post #6
nickysielicki wrote: post #2

The drug: https://en.wikipedia.org/wiki/Viloxazine tl;dr: It's an SNRI, like Effexor or Cymbalta.

> tl;dr: It's an SNRI, like Effexor or Cymbalta. The mechanism of action section specifically says that it did not block norepinephrine reuptake in the studied brains of rats (only in heart tissues) and that the serotonin reuptake inhibition was very weak. The mechanism of action is more complex, involving 5-HT2B antagonism and 5-HT2C agonism and some downstream upregulation of GABA-B in certain brain areas. It's lik…

It’s a real shit show is what it is. If you compare those side effects the ACTUAL side effects of stimulants in kids and adults with ADHD (for instance, it reduces drug dependency, addiction, hyperactivity in ADHD folks while having the opposite effect on those who do not have ADHD), it’s clear this should be unethical to prescribe for anyone stimulants would be effective on.

The only reason it even really comes up is the OMG stimulants are evil crowd who don’t want to even look at the reality of the situation.

Re: FDA approves new ADHD drug for children

#17

Post by nerdbaggy »

Seems that lots of people only think ADHD people have a hard time paying attention. If it was that simple I would be so happy. Here are just a few of the things I struggle with.

- Will power. People with ADHD struggle sooooo much with will power. It’s a constant struggle with everything in life and really wears you down.

- Constantly putting on a fake front pretending you don’t have ADHD.

- Rejection sensitivity

- Feeling inadequate, and unset at yourself for not being able to perform like peers

- Emotions swinging from happy to angry in a flash

- not being able to maintain friendships

- People thinking it’s not a real condition. Unless you have it you can’t even come close to understanding how much of a challenge every day is.

- Medication only helps with the attention issue for maybe 8 hours. It doesn’t help with the other 95% of the issues

This is by far the best what is it like https://gekk.info/articles/adhd.html and here is the corresponding HN https://news.ycombinator.com/item?id=22129777

Re: FDA approves new ADHD drug for children

#18

Post by thonos »

lazide wrote: post #11
Someone1234 wrote: post #8

Earlier quoted context omitted.

Do people "celebrate" ADHD-like dysfunction in adults? Seems like a lot of adults struggle substantially with those issues (in particular without a diagnosis).

If you overlap Elon Musks behavior (or a number of quite famous musicians) with ADHD diagnosis charts, you’re going to have a fun time. Like most things, we celebrate the high functioning folks and denigrate those who aren’t. Kids are also expected to fall in line and be easy to manage, and those that aren’t get medicated.

If you have resources and time to let your ADHD brain go free it can be fun, but it becomes a struggle when you try to be a working adult with normal job.

I'm not even talking about 'not being able to concentrate' because that's easily fixed with medicine. nowadays But ADHD is so much more involved on the emotional and psychological level.

My childhood was mostly 'driven by impulsivity', so having medicine available to me back then doesn't sound bad.

Re: FDA approves new ADHD drug for children

#19

Post by runawaybottle »

nerdbaggy wrote: post #17

Seems that lots of people only think ADHD people have a hard time paying attention. If it was that simple I would be so happy. Here are just a few of the things I struggle with. - Will power. People with ADHD struggle sooooo much with will power. It’s a constant struggle with everything in life and really wears you down. - Constantly putting on a fake front pretending you don’t have ADHD. - Rejection sensitivity - Fe…

None of you ever want to hear it, but everyone goes through this. It’s the human condition.

I’m an addict, and I’ve just justified with Herculean levels of mental gymnastics to keep abusing drugs/alcohol. There’s nothing you can say to me, I will convince myself it’s fine.

Edit: I spent most of my youth playing video games for 5+ hours daily. I had zero work ethic. It caught up to me and I worked hard to fix it, and believe it or not, it took years to fix (because I spent years being a slacker).

You are not going to just compete in this world for top grades and jobs if you are that behind in discipline, and I learned this the hard way.

But again, there’s a drug for that if you need a intermittent fix.

Re: FDA approves new ADHD drug for children

#20

Post by nerdbaggy »

runawaybottle wrote: post #19
nerdbaggy wrote: post #17

Seems that lots of people only think ADHD people have a hard time paying attention. If it was that simple I would be so happy. Here are just a few of the things I struggle with. - Will power. People with ADHD struggle sooooo much with will power. It’s a constant struggle with everything in life and really wears you down. - Constantly putting on a fake front pretending you don’t have ADHD. - Rejection sensitivity - Fe…

None of you ever want to hear it, but everyone goes through this. It’s the human condition. I’m an addict, and I’ve just justified with Herculean levels of mental gymnastics to keep abusing drugs/alcohol. There’s nothing you can say to me, I will convince myself it’s fine. Edit: I spent most of my youth playing video games for 5+ hours daily. I had zero work ethic. It caught up to me and I worked hard to fix it, and…

Spoken like somebody who doesn’t have ADHD. It sound stupid but it’s the truth. You can’t come close to relating if you don’t have it.
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