FDA approves new ADHD drug for children
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Re: FDA approves new ADHD drug for children
#2The drug: https://en.wikipedia.org/wiki/Viloxazine
tl;dr: It's an SNRI, like Effexor or Cymbalta.
Re: FDA approves new ADHD drug for children
#3For anyone curious about the proposed mechanism of action, care of the Wikipedia page https://en.wikipedia.org/wiki/Viloxazine
> Viloxazine, like imipramine, inhibited norepinephrine reuptake in the hearts of rats and mice; unlike imipramine, it did not block reuptake of norepinephrine in either the medullae or the hypothalami of rats. As for serotonin, while its reuptake inhibition was comparable to that of desipramine (i.e., very weak), viloxazine did potentiate serotonin-mediated brain functions in a manner similar to amitriptyline and imipramine, which are relatively potent inhibitors of serotonin reuptake.[11] Unlike any of the other drugs tested, it did not exhibit any anticholinergic effects.[11]
> More recent research has found that the mechanism of action of viloxazine may be more complex than previously assumed.[12] It appears to act as a potent antagonist of 5-HT2B receptors and as a potent agonist of 5-HT2C receptors.[12] These actions may be involved in its effectiveness for ADHD.[12]
> It has also been found to up-regulate GABAB receptors in the frontal cortex of rats.[13]
As always, a drug's effects cannot be interpreted simply by looking at binding affinities. It's important to focus on the actually human clinical trials. The binding affinities are interesting in the context of neuroscience and drug research, but less so for treatment decisions.
Re: FDA approves new ADHD drug for children
#4The drug: https://en.wikipedia.org/wiki/Viloxazine tl;dr: It's an SNRI, like Effexor or Cymbalta.
> It is a racemic compound with two stereoisomers, the (S)-(–)-isomer being five times as pharmacologically active as the (R)-(+)-isomer.[14]
I can't wait until 2041 when this is phased out and we get "esviloxazine" for $300+/month.
Re: FDA approves new ADHD drug for children
#5We normalize our children behavior with pills while celebrating diversity in adults. Interesting times...
Re: FDA approves new ADHD drug for children
#6The drug: https://en.wikipedia.org/wiki/Viloxazine tl;dr: It's an SNRI, like Effexor or Cymbalta.
> tl;dr: It's an SNRI, like Effexor or Cymbalta.
The mechanism of action section specifically says that it did not block norepinephrine reuptake in the studied brains of rats (only in heart tissues) and that the serotonin reuptake inhibition was very weak. The mechanism of action is more complex, involving 5-HT2B antagonism and 5-HT2C agonism and some downstream upregulation of GABA-B in certain brain areas. It's likely there are additional mechanisms that are not fully understood yet.
tl;dr: It's nothing like an SNRI like Effexor or Cymbalta. Always defer to actual patient outcomes in clinical studies instead of trying to infer a drug's effects based on binding affinities.
Re: FDA approves new ADHD drug for children
#7Kids dont like to sit in seats for 7 hours per day and look at a board. Interesting.
Re: FDA approves new ADHD drug for children
#8We normalize our children behavior with pills while celebrating diversity in adults. Interesting times...
Do people "celebrate" ADHD-like dysfunction in adults? Seems like a lot of adults struggle substantially with those issues (in particular without a diagnosis).
Re: FDA approves new ADHD drug for children
#9The drug: https://en.wikipedia.org/wiki/Viloxazine tl;dr: It's an SNRI, like Effexor or Cymbalta.
My first thought when I read the list of side effects was "this sounds like a bit like an antidepressant". Then I saw (from the original AP article) that it was, in fact, originally marketed as an antidepressant in Europe.
Re: FDA approves new ADHD drug for children
#10The drug: https://en.wikipedia.org/wiki/Viloxazine tl;dr: It's an SNRI, like Effexor or Cymbalta.
> tl;dr: It's an SNRI, like Effexor or Cymbalta. The mechanism of action section specifically says that it did not block norepinephrine reuptake in the studied brains of rats (only in heart tissues) and that the serotonin reuptake inhibition was very weak. The mechanism of action is more complex, involving 5-HT2B antagonism and 5-HT2C agonism and some downstream upregulation of GABA-B in certain brain areas. It's lik…
> It is a selective norepinephrine reuptake inhibitor (NRI).[1]
From the first paragraphe on wikipedia...