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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

371–380 of 430 posts

Re: Semaglutide linked to lower predicted dementia risk

#371

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A lot of this largely is not true. People think that paleothic humans ate a lot of meat - they did not. They ate very little meat, we eat the most meat we’ve ever eaten now. And the meat they did eat was lean game meat. It was high in unsaturated fats - like our modern day oils. Not like a steak. A steak is a product of farming. It’s a new invention, Yes oils are “refined”, but humans have been eating unsaturated oil…

People in certain regions always ate a lot of meat. For example, the Inuit don't really have anything else to eat. Nothing edible grows that far North. And they are neither obese nor suffer from classical diseases of civilization, until they start eating highly processed modern food. The Maasai are also known to eat a lot of meat and dairy.

I'm sure you can eat a diet fairly high in meat and dairy and be healthy, IF you are lean enough and exercise enough. However, I can pretty confidently say the Intuit did not eat nearly as much meat and dairy as modern Americans. And, the meat they did eat was not the same because it was wild, not farmed.

But, humans have been eating unsaturated fat from nuts, seeds, and meat for millennia. Unsaturated fat is not the devil. We have very strong evidence that a diet high in meat, particularly farmed red meat, is both carcinogenic and causes heart disease. When you look at high processed diets across the globe today, you'll notice they have similarities:

1. Extreme consumption of fatty, farmed meats

2. Very little fruits, vegetables, nuts, and other foods high in fiber

3. Processed shelf-stable goods

4. Extreme portion sizes

When people look at the Mediterranean diet, it's not just that they eat much more food high in unsaturated fat as opposed to saturated fat. They also eat less and move much more.

Re: Semaglutide linked to lower predicted dementia risk

#372

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Real sugar in your soda pop? What are you, a health nut? Must be a real my body is a temple sort. Seriously though, it's a dogshit thing to consume whether it is sweetened with HFCS or sucrose. "Even today, a Soda with 'real sugar', at least for me, is far more satiating" Did you know that in the acidic environment of a cola, sucrose quickly degrades into fructose and glucose (and if it didn't, your enzymes literally…

The idea that there’s some magic ingredient that makes soda a healthy choice is why discussion of “Junk food” Is so weird

I have thus far been unsuccessful at carbonating tea and coffee, and I have tried. Carbonated stuff tastes better, to me. And I love iced tea. However at night a diet caffeine free soda is much nicer to drink than decaf tea, and I always have said the day I drink decaf coffee is the day I give it up, as coffee isn't that delicious.

Re: Semaglutide linked to lower predicted dementia risk

#373

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

I have a very similar situation: on it for about a year, 220lbs to 180 at age ~40. Also very active: weight lifting / biking / swimming and - the sport that made me realize I needed to loose weight - rock climbing. I've always been very outdoorsy-adventurous, and climbing/mountaineering is the natural sort of "end game" for this lifestyle. My weight never really got in the way of anything else in my life (maybe my se…

Thanks for the details, really liked your posting this.

As a former Climber, moved to an area that doesn’t have a decent rock Gym and bought a house, this is inspiring. I have a chance to climb again and it will require losing some weight loss. I’m just a hair into the overweight category at the doctor.

One question: how tall are you?

Re: Semaglutide linked to lower predicted dementia risk

#374

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At the risk of being argumentative I had a horrible diet for the past ~10 years and carried 50 extra pounds. However I also exercised a lot as a hobby and to my shock my glucose and other bloods always came out in the normal range. This year I started Mounjaro and dropped the 50 pounds. Curious to see what my next checkup shows.

I had horrible diet and no excersise for many years. Still skinny. One person says nothing about the whole pop.

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Re: Semaglutide linked to lower predicted dementia risk

#375
post #310

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And it becomes even harder when you mix any of those two criteria, let alone more. Then factor in your environment. It is way easier to eat healthily in Italy than in the US. (Maybe that is what you meant with Food desert.)

Food Deserts are a concept that can exist anywhere but yes, I think they are more common in the rural USA. They are places that don't have nearby access to decent grocery stores, basically. Instead they have to buy all of their food from convenience stores. Imagine doing all of your food shopping at a gas station store because that's the only groceries around. That's a food desert. https://en.wikipedia.org/wiki/Food_…

Not just a rural thing. Plenty of poor areas in big cities have a dearth of affordable grocery stores.

Re: Semaglutide linked to lower predicted dementia risk

#376

Diabates can harm the brain either indirectly, through vascular damage, or directly through nerve cell degeneration. The latter is a less studied mechanism and can explain the benefit from GLPs. But I agree, it's not different than a low calorie diet. In the modern times of abundance and sedentary lifestyle, fasting makes wonders. So, if you have even one vascular risk factor, just cut your calories in half, just sto…

GLP-1 provides the only plausible way to do so.

This is just flat out untrue. Going a day or two without eating anything feels freeing and wonderful. You simply have some coffee and go through your day, drink water. By not eating anything at all it’s much easier. Even having a couple bites of food gets the body revved up to eat more. Fasting is a choice to simply not. To abstain. To stop and pause. This idea is so un American that I believe people are simply unaware and unable to process the notion.

Putting this idea in people’s mind, that they will be OK if they don’t eat for a day, would be revolutionary. However, companies want to sell things rather than simply give people a basic idea and open their world to possibilities.

Re: Semaglutide linked to lower predicted dementia risk

#377
post #336

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I think you’re misunderstanding the fat acceptance movement. It’s about separating the illness from the person, not about obesity health. In our society it would be impossible to be unaware that obesity is unhealthy. People go out of their way to be mean to fat people. The fat acceptance movement is essentially “please don’t do that”.

It’s both. There is a very vocal contingent who insist that obesity is not unhealthy.

Re: Semaglutide linked to lower predicted dementia risk

#378

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Just pattern matching as an autistic human. Similar results were seen on a ketogenic diet (and to some extent, intermittent fasting). What do they have in common? Sugar intake reduction. Is it surprising sugar potentially fuels cancer, contributes to dementia, etc? It shouldn’t be. It’s indirect and a casual connection. There is no health benefit to a high sugar or Western diet, only downside. I think calling it pois…

Thats due to caloric restriction. A high fat diet isn't going to helpful as well. To think that people cut sugar but continue to eat far too much meat and fat... yikes.

Lol there's only three macros. If you cut out carbs you necessarily increase protein and fat, for the same calories. Unless you are merely saying people should eat less; but that should go without saying.

Re: Semaglutide linked to lower predicted dementia risk

#379

Earlier quoted context omitted.

GLP-1 provides the only plausible way to do so.

This is just flat out untrue. Going a day or two without eating anything feels freeing and wonderful. You simply have some coffee and go through your day, drink water. By not eating anything at all it’s much easier. Even having a couple bites of food gets the body revved up to eat more. Fasting is a choice to simply not. To abstain. To stop and pause. This idea is so un American that I believe people are simply unawa…

This simply isn't how any addiction works. You can just as well say to an alcoholic to "just stop drinking". Humankind tried to rid itself of obesity for too long and it only kept getting worse. GLP-1 is the key.

Re: Semaglutide linked to lower predicted dementia risk

#380
post #367

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There are several studies now showing that recommendations like "losing weight" are taken less seriously by overweight patients.

Whether patients make good choices is completely independent from whether doctors provide everyone with equal quality of care. Specifically, doctors are less likely to investigate issues that can be explained by obesity than they are in non-fat people. For example, if you have high blood pressure and you are a normal weight your doctor will probably look into underlying conditions that can cause high blood pressure.…

Doctors are probably also less likely to look for other causes of chronic cough in smokers.

In general doctors are looking for the most obvious potential causes of a health problem. If someone on high dose anabolic steroids went to the doctor with him blood pressure, the doctor would probably tell them to cut out the steroids as the obvious answer rather than exploring other reasons the patient’s blood pressure might be high.

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