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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#301

Post by NorthSouthNorth »

01100011 wrote: post #204
NorthSouthNorth wrote: post #187

Earlier quoted context omitted.

People bonk because they're not eating enough DURING the ride. I'll eat (actually mostly drink) like 120-200g carbs on longer rides. Record is 700g during a 200km ride. I've seen big guys bonk too. It has very little to do with your BF% (although this is nuanced based on power zones and training 'durability' etc, etc).

Going back to my endurance days, I think people bonk because they aren't adapted. After a year or so of pushing through the bonk, and growing up with hypoglycemia if I didn't eat frequently, I got to where I could start out at 5am on an empty stomach and not eat until noon or later. If I did bonk, I'd sip V-8(yeah, really) and instantly recover.

Yeah this was the attitude back in the day and I know some older guys with this mindset but the science on this is pretty clear.

It’s definitely one of, if not the most, currently focused on aspects of endurance sports outside of the actual training.

Re: Semaglutide linked to lower predicted dementia risk

#302

Post by procaryote »

ThrowawayTestr wrote: post #178
SubmarineClub wrote: post #167

Earlier quoted context omitted.

[flagged]

It's really not hard to not drink. It's really not hard to not do heroin. It's really not hard to...

Those are easier in many ways as you don't need heroin or alcohol to survive and can avoid it completely

If it's hard or not is more of a philosopical question about how much free will we have as people. Statistically they're all hard and not over-eating is the hardest.

Culturally and individually we do a lot of things that probably make the food one even harder

If you drink too much, the common answer is that you need to stop drinking. If you eat too much, we are very reluctant to talk about how you need to eat less. We prefer to talk about how it's someone else's fault and how powerless we are to do anything about it, including comforting lies about how eating less wouldn't work anyway, or how being overweight isn't bad really.

Re: Semaglutide linked to lower predicted dementia risk

#303

Post by onefish »

01100011 wrote: post #38

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

I have a very similar situation: on it for about a year, 220lbs to 180 at age ~40. Also very active: weight lifting / biking / swimming and - the sport that made me realize I needed to loose weight - rock climbing. I've always been very outdoorsy-adventurous, and climbing/mountaineering is the natural sort of "end game" for this lifestyle. My weight never really got in the way of anything else in my life (maybe my self esteem) but, this might offend some people, but climbing is a sport where you really cannot be even a little bit fat. It makes you painfully aware of your body weight. Most "good" climbers are built like bean-poles. I don't really need to be a "good" climber, just an "okay" and safe climber - I'm mostly interested in alpine trad below ~5.7. I still feel like I need to lose another 10lbs.

I was a fat kid growing up. I've had a BMI of 30±1 since age 12. I also have a family history of heart disease. Literally every male on my father's side for three generations has had a heart attack in their late 50s. We all have roughly the same body type. I already had hypertension in my mid 30s. Semaglutide has made me feel like there's hope.

Unfortunately, I can relate to the lower energy levels. While I'm no longer lugging an extra 40lbs around (a full pack!), I still bonk way faster. My gym sessions are way shorter. Luckily, I haven't lost much muscle mass, so I look great and it's been the "cut" I've never been able to achieve, but I'm sure if I ever wanted to "bulk" I'd have to go off it. I've found if I have a big trip or climb coming up, I have to take a way smaller dose the week, or even weeks, prior. I found this out the hard way when I puked on a climb in North Cascades. I just couldn't eat, and felt like shit the whole time.

The trick has been self managing my dose. I'm on compounded generic, so I can dose myself with my own needles. If I have a big trip coming up, I'll take like 25% of my maintenance dose for a week or two prior. This has been almost a superpower, because I'll get this massive burst of energy from the calorie intake. Im still not really sure if this is healthy, not the "taking 25%" part, but the fact that I feel like superman when I'm off it or on a low dose for a bit. Not sure what this says for someone who is basically taking semaglutide because their weight was holding them back from the activities semaglutide makes them too bonked to do anyways.

Re: Semaglutide linked to lower predicted dementia risk

#305

Post by nwienert »

Aurornis wrote: post #35
anonuser123 wrote: post #16

Read a interesting piece recently that Semaglutide reduces inflammation, and very likely the weight-loss and a lot of the other emerging benefits are likely the effects of reduced inflammation.

> and very likely the weight-loss and a lot of the other emerging benefits are likely the effects of reduced inflammation. That’s not correct. GLP-1s interact with satiety (fullness) circuits and reduce appetite. They also have minor effects delaying gastric emptying, meaning the stomach stays full longer. There is some early data suggesting that they might reduce some inflammation markers slightly more than weigh lo…

> The question now is if GLP-1s have additional anti-inflammatory influence.

This is well established, not at all a question.

> they might reduce some inflammation markers slightly more than weigh loss alone

There's no "slightly," It's going to be a news story for years to come. It's a broad spectrum anti-inflammatory drug of a breadth and efficacy never seen before.

Re: Semaglutide linked to lower predicted dementia risk

#306

Post by victorbjorklund »

zemvpferreira wrote: post #55
victorbjorklund wrote: post #22

Earlier quoted context omitted.

Doubt you can eat just pure fructose for 30 years and ”move” and avoid diabetes.

At the risk of being argumentative I had a horrible diet for the past ~10 years and carried 50 extra pounds. However I also exercised a lot as a hobby and to my shock my glucose and other bloods always came out in the normal range. This year I started Mounjaro and dropped the 50 pounds. Curious to see what my next checkup shows.

I had horrible diet and no excersise for many years. Still skinny. One person says nothing about the whole pop.

Re: Semaglutide linked to lower predicted dementia risk

#309

Post by [deleted] »

WarmWash wrote: post #67
Aurornis wrote: post #50

Earlier quoted context omitted.

That is the question now. Some studies have some early evidence that GLP-1s might reduce inflammation markers a little more than weight loss alone. Giving GLP-1s to normal weight people doesn’t work well because they can have to work harder to maintain their weight. That can be a real problem as people get older where maintaining muscle mass is important for quality of life and longevity. I remember how hard it was t…

My assumption was that GLP-1's don't suppress appetite so much as suppress the compulsion to eat when not necessary/more than necessary?

[deleted]

Re: Semaglutide linked to lower predicted dementia risk

#310

Post by spockz »

bluefirebrand wrote: post #274
SubmarineClub wrote: post #167

Earlier quoted context omitted.

[flagged]

It can be very hard to eat a healthy diet if you're poor or if you live in a food desert, or you have a dietary restriction, or some allergies...

And it becomes even harder when you mix any of those two criteria, let alone more. Then factor in your environment. It is way easier to eat healthily in Italy than in the US. (Maybe that is what you meant with Food desert.)
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