Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

Post reply on HN
Print view View original

271–280 of 430 posts

Re: Semaglutide linked to lower predicted dementia risk

#271

Post by xgkickt »

object-a wrote: post #106
hattmall wrote: post #42

Earlier quoted context omitted.

Treat junk food like cigarettes

What is junk food? For example — are cheeseburgers and French fries junk food? What about when you make them at home, or at a fancy restaurant without artificial ingredients? Is it certain additives? If McDonalds makes a happy meal without additives, is it no longer junk food? What does treat them like cigarettes mean? Tax them? Ban them within 15 feet of a building entrance? Put warning labels? Is giving or selling…

Like cigarettes, simply ban the advertising.

Re: Semaglutide linked to lower predicted dementia risk

#272

Post by [deleted] »

eapressoandcats wrote: post #119
WarmWash wrote: post #67

Earlier quoted context omitted.

My assumption was that GLP-1's don't suppress appetite so much as suppress the compulsion to eat when not necessary/more than necessary?

They also clearly have some impacts on metabolism. It’s well known that a challenge with dieting isn’t just eating less, it’s metabolic changes that make weight loss harder. GLP-1’s avoid that.

[deleted]

Re: Semaglutide linked to lower predicted dementia risk

#273

Post by keepupnow »

object-a wrote: post #150
wackget wrote: post #120

Earlier quoted context omitted.

Most of the time when people try to define healthy food vs. junk food in a fair and unbiased way, the line gets drawn at "whole foods" vs "processed foods". A typical burger meal is definitely processed food because the meat is processed mechanically and mixed from different sources (usually with added fat); the bun is made from refined flour and refined oils; and the fries are thinly-cut potatoes blanched and fried…

Why does grinding the meat at home make a huge difference vs grinding it in a factory? Depending on the cut you choose, the condiments you add, and the portion size, a hamburger at home could be Lot less healthy than a McDonald’s burger. McDonald’s patties don’t have any fillers afaict. The point is that “junk food” is a pretty amorphous and vague category. If you want to enforce portion or calorie restrictions you c…

[dead]

Re: Semaglutide linked to lower predicted dementia risk

#274

Post by bluefirebrand »

SubmarineClub wrote: post #167
OptionOfT wrote: post #158

Earlier quoted context omitted.

We're too soft on companies, but equally too hard on people who have a food addiction.

[flagged]

It can be very hard to eat a healthy diet if you're poor or if you live in a food desert, or you have a dietary restriction, or some allergies...

Re: Semaglutide linked to lower predicted dementia risk

#275

Post by zhivota »

Aurornis wrote: post #50
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

That is the question now. Some studies have some early evidence that GLP-1s might reduce inflammation markers a little more than weight loss alone. Giving GLP-1s to normal weight people doesn’t work well because they can have to work harder to maintain their weight. That can be a real problem as people get older where maintaining muscle mass is important for quality of life and longevity. I remember how hard it was t…

I'm normal weight and am on a low dose (1mg every 10 days) of tirzepatide. I'm able to maintain my weight at this dose, and I've seen improvements in inflammation and other blood markers as well. It's not impossible, it's just difficult to do within the normal health system parameters (specific dosages tested for weight loss, etc.). I use a gray market supplier direct from China and reconstitute the dose myself.

Re: Semaglutide linked to lower predicted dementia risk

#276

Post by zhivota »

Jaygles wrote: post #172
jaggederest wrote: post #117

Earlier quoted context omitted.

Speaking as someone who had the same kind of reservations, I think you sound exactly like me, and if I had any advice to my past self, it would be "get on it as early as it's available, start much lower than anyone thinks is sane, and never ever stop". I got a concierge doctor who absolutely evaluates what I ask for skeptically, and pay for my GLP medications out of pocket, so I feel ethically totally comfortable wit…

What downsides have you experienced?

Mine were mainly around bloating and abdominal pain, but I solved it by spacing the doses out further to once every 10 days (I'm already about as low as you can get at 1mg without making it difficult to measure accurately in the normal insulin syringe). My working theory is some people don't clear the drug as fast as the modeled rate, so once every 7 days starts to slowly accumulate. I didn't have symptoms until after 12 weeks on a weekly dose.

Re: Semaglutide linked to lower predicted dementia risk

#277

Post by phil21 »

to11mtm wrote: post #225
tacon wrote: post #147

Earlier quoted context omitted.

No, the evidence is that there is no significant difference in satiety. HFCS is 55% fructose / 45% glucose, while sucrose is 50% fructose / 50% glucose.

Well, There's at least this as a start... https://nutrition.org/sugars-created-equal-lets-talk-fructos... Not saying Sugar itself is much better, however, yes, there is research indicating that the two are metabolized differently, so that difference in composition should be considered.

I am entirely unconvinced that a 5% difference in fructose vs. glucose is a meaningful difference.

They carry the same health risks if eaten in the same amounts. The only thing that corn syrup could be blamed for here is being too cheap so it shows up in greater quantity and in more products than cane sugar might otherwise.

HFCS is just one of those fashionable things to be "concerned" about so we can all miss the forest through the trees.

Re: Semaglutide linked to lower predicted dementia risk

#278

Post by zhivota »

01100011 wrote: post #129
brianfryer wrote: post #30

Earlier quoted context omitted.

Semaglutide clears liver fat? I had no idea. I’m curious to know more about your protocol

My protocol was to take semaglutide As a consequence I ate less. Weirdly, I think I eat more sugar now but my total calorie intake is lower. I eat more sugar because sometimes it's the only thing that seems palatable or I'm trying to counteract the hypoglycemia feelings.

I have this same reaction sometimes, I don't have the desire to eat a full meal with protein and fat, but a little candy is palatable. It's probably not a good idea overall to be honest, it would be better to just "save up" hunger for a more balanced meal.

Re: Semaglutide linked to lower predicted dementia risk

#279

Post by phil21 »

throwaway82931 wrote: post #110
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

All my immediate family members are obese. I'm not (BMI 24.5, borderline overweight at the high end of normal, highest lifetime BMI was 29.5), but that's through strenuous, exhausting effort over decades. I also exercise regularly, though I've learned over time how disconnected exercise is from weight management. At my weight, I'm not a candidate for going on a GLP-1. I'm sure I could find an unethical doctor to pres…

> I'm sure I could find an unethical doctor to prescribe it if I looked hard enough

I'd say the only unethical doctors here would be the ones not prescribing it for you based on your description of your life and needs.

Guidelines are guidelines, not strict rules for a reason. BMI is not the end-all measurement to decide if you are a candidate for these drugs.

Find a competent doctor who understands GLP-1s and you might be surprised.

Re: Semaglutide linked to lower predicted dementia risk

#280

Post by phil21 »

object-a wrote: post #106
hattmall wrote: post #42

Earlier quoted context omitted.

Treat junk food like cigarettes

What is junk food? For example — are cheeseburgers and French fries junk food? What about when you make them at home, or at a fancy restaurant without artificial ingredients? Is it certain additives? If McDonalds makes a happy meal without additives, is it no longer junk food? What does treat them like cigarettes mean? Tax them? Ban them within 15 feet of a building entrance? Put warning labels? Is giving or selling…

> For example — are cheeseburgers and French fries junk food? What about when you make them at home, or at a fancy restaurant without artificial ingredients? Is it certain additives? If McDonalds makes a happy meal without additives, is it no longer junk food?

Yes, this is all junk food. It's not that difficult.

Eaten in moderation these things are fine. But they are highly palatable calorie dense meals that are not great for you over time and in huge quantity. A burger is generally speaking a burger, regardless of how fancy. Deep fried stuff is deep fried, regardless of the cut of the vegetable or how organically it was grown.

Your latter question is far more interesting to me. I don't have a solution for that really. Society gets what society demands. I don't know how you'd fix those incentives without seriously horrible second and third order effects.

Post reply on HN