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There's an important detail missing: the dose. I gather that the therapeutic dose is on the order of 500 mg/day. So did they eat 10x that, 100x that, or what?
Given it's a bulk cleaning product, they'd need some damn finely calibrated scales to measure out anything more precise than "a pinch". Which clearly isn't good when 3x the clinical dose will land you in hospital.
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Yeah, which only establishes that the baseline understanding the common person has when taking drugs is to take the recommended dose. And nowhere was Trump saying "go crazy".
Alternately, that (legally-mandated?) warning is there because a non-negligable portion of the population needs regular reminders that more isn't always better.
People come up with crazy, brain dead ideas all the time. There are flat earthers for crying out loud.
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From the page linked in the article: "A man has died and his wife is under critical care after the couple, both in their 60s, ingested chloroquine phosphate, an additive commonly used at aquariums to clean fish tanks.". Did he literally just consume fish tank cleaner? That seems like a really easy way to mess up dosing.
yes, that is precisely what happened
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Lithium, valproic acid, anticoagulants and -mycin antibiotics (topical excluded) and all anti-depressants are not available OTC in the US. Acetaminophen has a therapeutic index of close to 8, much better than chloroquine.
I am not really sure why you think I was listing only OTC drugs. Chloroquine does require a prescription in the US, so comparison with other prescription drugs seems entirely reasonable to me. Two points on the topic of OTC drugs in the US: 1. Unfortunately you can buy Lithium as a supplement in the US. I have seen bottles of it for sale on Amazon. 2. Having seen enough accidental (not to mention intentional) overdos…
You are correct that there is a "gray market" for some compounds. The FDA won't come after you for selling lithium carbonate as long as you're not touting it as a medicine. I assume that if it became widespread enough and people got injured, those products would be pulled off the market pretty quickly.
My comments of the TI for acetaminophen was more that it was larger than that for chloroquine. No drug is "safe", but some are safer than others.
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Verbatim quote from the President: "if things don’t go as planned, it’s not going to kill anybody." Edit: Yes, I realize what he probably meant . I know how meds work. I still think he should have chosen his wording more carefully.
This quote does not literally say or imply one should self medicate. This quote in context appears to misrepresent the lethal dosage of the medication.
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Luckily a lay person cannot get medical grade chloroquine. They can purchase a chemical to use in aquariums, but that is not medication. Those chemicals are not regulated, and may contain all sorts of other compounds that could kill humans, or have an incorrect amount of chloroquine. Sorry, no matter what the president says, self-medicating is nuts.
It’s obviously nuts to take medical advice from Donald Trump. However, some people will do it, which makes it irresponsible to give such advice, even obliquely.
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Acetaminophen doesn’t belong in this conversation with the other drugs. I don't see why not? It's a good example where the max therapeutic dose (4000mg/day) is within 2X of the toxic dose range (7500mg-10000mg/day). And even the max therapeutic dose can be toxic to the liver. And it's exceptionally easy to accidentally overdose if you don't read product labels, since you could be taking multiple products that contain…
Almost no one should be taking 4g of acetaminophen a day. That’s definitely going to be toxic given enough time. It doesn’t belong in convo with other drugs because it requires far less monitoring. It’s also not taken chronically like the other drugs. Or shouldn’t be, at least.
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Post a link because I right now I have no reason to believe you.
He probably means this: https://www.fiercebiotech.com/medtech/fda-expands-access-to-... But that has nothing to do with HIV, neither do garlic and beetroot have anything to do with nitric oxide.
"Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications."
https://www.ncbi.nlm.nih.gov/pubmed/7555034
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A relevant data point. I don't think this is a good way to share public health information. @realdonaldtrump 7:13 AM - 21 Mar 2020 HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine. The FDA has moved mountains - Thank You! Hopefully they will BOTH (H works better with A, International Journal of Antimicrobial Agents)..... ....be put…
Seems completely reasonable to me. He says "have a real chance". He's not promising they work and stating that he and the FDA are doing everything they can to find treatments.
Dr Fauci spoke right after Trump first brought up the drug and confirmed it’s something not yet proven as a treatment, except some early studies in France, but something that should be looked into. Trump brought it up a few minutes later, again in the context of the FDA approving it for study.
Regardless, I’m sure it made a lot of doctors and pharmacists cringe hearing any drug brought up. I saw a lot of people afterwards saying Trump was recommending it as a treatment without any context, so in a politically charged sound-bite era there will always be the risk of it being misinterpreted... or people willfully ignoring the context and Guinea-pigging themselves.
One good thing is that it already requires a doctors prescription to buy (same with Canada).
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Are you arguing that the chloroquine they took, as chloroquine phosphate, is different from the chloroquine that's used to treat malaria? That's more than "a similar name". It's the same name. From what I've read, both chloroquine and hydroxychloroquine are used to treat inflammation. So is it chloroquine vs hydroxychloroquine that you're referring to?
I'm not qualified to comment on what differences exist between chloroquine and hydroxychloroquine, I'm pointing out that aquarium cleaner tablets are not medicine. Even if the names are the same, you have no idea what a tablet like that is cut with.
But still, fish aren't people. So using anything except pharmaceutical grade is dangerous.
0) https://www.reef2reef.com/threads/chloroquine-phosphate.1923...