271–280 of 456 posts
Well, time to pick up Tylenol shares on the dip.
There is research correlating autism and mothers taking certain medications (painkillers, antidepressants). Since autism is hereditary, there is a significant chance that these mothers are autistic too. Autistic people have a vastly high risk of depression, and often have unusual pain thresholds, requiring more painkillers. I would not be surprised of the correlation was real, but the direction of action was reversed…
But I could certainly imagine that a mother with autistic traits could be someone who takes painkillers more often than the average person.
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If Paracetamol was invented today it would likely never receive an OTC (over the counter sale, meaning you can just buy it from a retail outlet the way you'd buy cough medicine or toothpaste) license in the UK. Yes, it's safe (and for a bunch of people including me, effective) at the licensed dose, but it's useless at about half that dose, and it's toxic, leading to very nasty deaths in some cases, at just about 3-4…
Always surprises me as an American in the UK how hostile the UK is to paracetamol. You buy it in like 300-pill packages in the US, and I've literally never heard of anyone having a single accidental over-dose. I'm not sure I've ever heard of anyone intentionally overdosing on it, but I guess I can't rule that out since I'm aware of who 1-2 people personally have taken "a handful of pills". The efficacy window of driv…
Earlier quoted context omitted.
If Paracetamol was invented today it would likely never receive an OTC (over the counter sale, meaning you can just buy it from a retail outlet the way you'd buy cough medicine or toothpaste) license in the UK. Yes, it's safe (and for a bunch of people including me, effective) at the licensed dose, but it's useless at about half that dose, and it's toxic, leading to very nasty deaths in some cases, at just about 3-4…
Always surprises me as an American in the UK how hostile the UK is to paracetamol. You buy it in like 300-pill packages in the US, and I've literally never heard of anyone having a single accidental over-dose. I'm not sure I've ever heard of anyone intentionally overdosing on it, but I guess I can't rule that out since I'm aware of who 1-2 people personally have taken "a handful of pills". The efficacy window of driv…
Earlier quoted context omitted.
> The only side-effect is euphoria. > … > the problem is with […] people misusing / abusing them. I think these two facts are inextricably linked, and is what makes them indirectly dangerous for some people.
I do not disagree. Ultimately, it is "pick your poison[1]". [1] Or others will pick it for you (control, regulation, whatever). You said "some people", which is true. I do not experience euphoria from opiates and I am sure I am not alone with this. In my case it is a blessing because I do have an addictive personality. Some other people do not get psychologically addicted to opiates despite euphoria. There is a great…
There's no avoiding it when it comes to some people's chronic pain but it's a tragedy we've ruined the reputation for opiate painkillers because they were prescribed for long periods which all but guarantees addiction. Folks in US hospitals have to unnecessarily suffer short term acute pain because squeamishness around prescribing effective painkillers in a situation where there's virtually no risk.
There is research correlating autism and mothers taking certain medications (painkillers, antidepressants). Since autism is hereditary, there is a significant chance that these mothers are autistic too. Autistic people have a vastly high risk of depression, and often have unusual pain thresholds, requiring more painkillers. I would not be surprised of the correlation was real, but the direction of action was reversed…
Yep. Two of my 5 are clearly HFA (1 diagnosed) and another shows strong indications. My wife and I have numerous family members that are somewhere on the spectrum. It's how this works.
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And nausea. Yuck.
Some people have it. Some do not. I have taken very large amounts of opiates before and I have never ever experienced nausea from them. I think you are not likely to experience it at lower doses from say, codeine or hydrocodone either, but honestly, it varies by individuals. It would suck if I experienced nausea, and it would equally suck if I experienced euphoria from opiates, because I have an addictive personality…
Here's the relevant study from earlier this year: https://hsph.harvard.edu/news/using-acetaminophen-during-pre... It's a meta-analysis that considered a bunch of individual studies, their effect size, and their quality. It claims that Tylenol use has increased alongside a 20-fold increase in autism rates, suggesting causation, and recommends immediate efforts to reduce Tylenol use during pregnancy. One objection that…
Every charlatan researcher grifting on bogus autism data really is just copying Andrew Wakefield's homework
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Sure it can. Type 2 diabetes is both hereditary and lifestyle/behavioral influenced . Same with cancer, if you have cancer in your family your risk of getting cancer is higher. I would say most medical issues are both. Heart disease, gout, obesity, hypertension,strokes,asthma etc.
Let me put this a bit differently: Type 2 diabetes is both genetic and can be acquired during one's life (e.g. through bad dietary choices). But a man who develops diabetes does not acquire genetic T2D by doing so - he cannot pass it on directly to his children.
How we pass on acquired traits to offspring is not well understood at all. We know there’s a mechanism, but not how it works or how selective it is.