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Ozempic shows anti-aging effects in trial

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Re: Ozempic shows anti-aging effects in trial

#271

Post by glp1guide »

noah_buddy wrote: post #20
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

I agree with this take but want to add that once everyone is doing it, these opinions will change drastically and everyone will pretend like they were never against it.

Another interesting question is where do people go from there? What is the next signal of virtue, I wonder.

Re: Ozempic shows anti-aging effects in trial

#272

Post by glp1guide »

hollerith wrote: post #19
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

The drug companies are very good at making new drugs with high profit potential look better than they are. I'm worried semaglutides are another fen-phen, Vioxx, Quaaludes, Trovafloxacin or OxyContin. One thing to watch for is effect size: how big of an anti-aging effect does Ozempic confer relative to other good interventions? Were the subjects doing other solid anti-aging interventions like the Fasting Mimicking Die…

Don't worry, GLP1 RAs are nothing like those other drugs. In fact I'd really challenge you to examine even one of the correlations there, the scale of research, use, known side effects, effectiveness is completely different.

The idea that people might only benefit from something like Ozempic a little if they were doing some other intervention before is irrelevant, because no one is doing those other interventions. Requiring people to suffer before providing useful, known-safe and well-researched medication is silly.

Medication is technology.

Re: Ozempic shows anti-aging effects in trial

#273

Post by CalRobert »

Levitz wrote: post #195
hinkley wrote: post #124

Earlier quoted context omitted.

You've got a crowd of people raised in a Calvinist society who think nothing good comes without suffering, you've got people who feel this is a cheat where discipline should win out, and you have a bunch of people who are used to all easy solutions coming with either a bad lottery ticket or externalities on other people/the environment. They can all agree that they're waiting for the other shoe to drop. That said, we…

You've also got the crowd who would argue that there's nothing wrong with being fat in the first place and that are scared of society pressing on this matter again after years of pushback.

As someone who was 100 pounds overweight for a long time, and now isn't, that mindset is really dangerous and preventing a lot of people from living life to its fullest.

There is never any reason to be cruel or unkind to people who are overweight, but pretending that it doesn't have negative consequences or is even "healthy for me" or whatever is really harmful.

Re: Ozempic shows anti-aging effects in trial

#274

Post by fortran77 »

glp1guide wrote: post #269
jjice wrote: post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

We think obesity is basically going to be gone in This is going to accelerate when every one and their mother (with industrial capacity) starts making generic Ozempic/Wegovy (Semaglutide) next year due to Canada's patent protection lapse[0]. https://glp1.guide/content/novo-nordisk-patent-protections-l...

I think that, just like with stomach reduction surgery, people are going to find a way to overeat and gain weight while taking Ozempic too.

Re: Ozempic shows anti-aging effects in trial

#275

Post by glp1guide »

lysecret wrote: post #23

It’s so fascinating that we just keep on finding more positive effects.

We also like to keep track of all the bad ones too[0] (tl;dr they're actually pretty reasonable).

It's amazing what lowering inflation, reducing body weight can do to the body. It's almost becoming irrelevant that GLP1 Receptor Agonists were originally for type 2 diabetes (i.e. reducing HbA1c) -- the effects are profound. Kidney health, heart health, overall health, longer lives -- all for the low low cost of gastrointestinal problems (which can be serious, especially if dehydrated).

[0]: https://glp1.guide/content/are-glp1-side-effects-all-the-sam...

Re: Ozempic shows anti-aging effects in trial

#276

Post by wonderwonder »

throwawaylaptop wrote: post #142
radiofreeeuropa wrote: post #58

Earlier quoted context omitted.

It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. Like, I figured we were just never going to solve it, given the two possibilities were "radically re-engineer US culture such that moving to the US doesn't make previously-skinny people fatter" (with other countries heading the same direction as us needing to make similar moves, one supposes) or "find…

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

I think its great you helped your dad lose weight but what is your issue with others choosing a different path? The health benefits of losing weight are massive . Why is it important to you that they do it how you want them to do it? Study after study has sung the praises of GLP-1s.

It appears that your major issue is that you are simply angry people are taking a short cut. Which seems odd, why would it bother you how someone lost weight, why not just be happy for them?

I got on GLP1s in January. I went from 6'1 240lb to 209lbs with defined abs benching 405lbs at 46 years old. I've worked out my entire life but never been lean like this. I like eating bread (steak, eggs, toast, ketchup and hot sauce is perhaps the single greatest breakfast in the history of the world. The toast is very important!) and potatoes are freaking incredible (mashed with Worcestershire sauce... bruv).

The bulk of my calories are protein but I generally eat what I want if I desire it. I just desire less of it. I had a roast beef sub from Jersey Mike's today with my kid, it was delicious. Their honey mustard is the bee's knees. I had a medium sub though and not a large.

The only change is now I essentially don't eat after 6pm. I just set that goal and the GLP-1 helped me keep it. The only side effects I have had is lower cholesterol and lower BP and that is while running 700mg of test. I'm going to hop on metformin next month after this cycle and target eliminating the fatty liver markers I have had for the last 20 years.

They work friend, they are good for you and they make people live happier healthier lives.

Embrace better living through chemistry.

Re: Ozempic shows anti-aging effects in trial

#277

Post by m463 »

glp1guide wrote: post #269
jjice wrote: post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

We think obesity is basically going to be gone in This is going to accelerate when every one and their mother (with industrial capacity) starts making generic Ozempic/Wegovy (Semaglutide) next year due to Canada's patent protection lapse[0]. https://glp1.guide/content/novo-nordisk-patent-protections-l...

> We think obesity is basically going to be gone in I wonder if this is for wealthy people

(...who might be the target market - being overweight might be a disease of affluence)

Re: Ozempic shows anti-aging effects in trial

#278

Post by esseph »

throwawaylaptop wrote: post #199
parineum wrote: post #198

Earlier quoted context omitted.

If I told you billions of people eat bread, sugar and pasta and it wasn't "basically killing them" (whatever that means)... It's strange to make the culprit of a modern epidemic foods that have been with us for millenia.

Billions of people were not overweight when they ate those things. They did not eat them 3+ times a day. I said in my other posts.. if someone needs help maintaining or gaining weight, eat those things. If you are overweight, you should be eating ZERO of them. "Basically killing them" means whatever the current obesity and type 2 diabetes epidemic means.

Hey, question, what's the most popular food across Asia?

Re: Ozempic shows anti-aging effects in trial

#279

Post by iwsk »

throwawaylaptop wrote: post #142
radiofreeeuropa wrote: post #58

Earlier quoted context omitted.

It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. Like, I figured we were just never going to solve it, given the two possibilities were "radically re-engineer US culture such that moving to the US doesn't make previously-skinny people fatter" (with other countries heading the same direction as us needing to make similar moves, one supposes) or "find…

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

It took you 10 years to get him to give up bread, sugar, potatoes? This approach would be hard to scale.

Re: Ozempic shows anti-aging effects in trial

#280

Post by grigri907 »

hinkley wrote: post #124
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

You've got a crowd of people raised in a Calvinist society who think nothing good comes without suffering, you've got people who feel this is a cheat where discipline should win out, and you have a bunch of people who are used to all easy solutions coming with either a bad lottery ticket or externalities on other people/the environment. They can all agree that they're waiting for the other shoe to drop. That said, we…

That first paragraph could be the preamble to every conflict in my life and it would be evergreen
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