Ozempic shows anti-aging effects in trial • Hacker News Board

Re: Ozempic shows anti-aging effects in trial

#191

Post by stavros » Tue, Aug 05, 2025, 10:18 PM UTC

throwawaylaptop wrote: post #142

radiofreeeuropa wrote: post #58

Earlier quoted context omitted.

It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. Like, I figured we were just never going to solve it, given the two possibilities were "radically re-engineer US culture such that moving to the US doesn't make previously-skinny people fatter" (with other countries heading the same direction as us needing to make similar moves, one supposes) or "find…

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of Ozempic. Once he saw what stopping the cravings for certain foods can do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird bionic arm implant.

Re: Ozempic shows anti-aging effects in trial

#192

Post by snek_case » Tue, Aug 05, 2025, 10:20 PM UTC

Aurornis wrote: post #111

noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

> Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. I feel like I've seen and heard more of the opposite: The trend is to avoiding anything that might make someone feel blame for arriving in their situation. With obesity the trend is to blame some combination of "our food supply", trending science topics like microplastics or th…

Genetics do factor. It's not just a question of genetics affecting metabolism. People literally don't feel hunger with the same intensity as one another. It's like sex drive. There are both very horny people and asexuals out there. There are also people who routinely forget to eat. For many people though, the notion of "forgetting to eat" seems completely alien, because those signals are much stronger for them.

Re: Ozempic shows anti-aging effects in trial

#193

Post by throwawaylaptop » Tue, Aug 05, 2025, 10:28 PM UTC

radiofreeeuropa wrote: post #187

throwawaylaptop wrote: post #185

Earlier quoted context omitted.

[flagged]

Run a study of your approach and show good results over a cohort for 2+ years and you'll make an entire sub-field of medical scientists very happy. [EDIT] It's not that your approach can't work, it's that if (for example) people had as hard a time following the directions for condoms as they do following diet & workout plans, we'd never allow condoms to be sold as contraceptives, they'd not even be close to being OK…

[flagged]

Re: Ozempic shows anti-aging effects in trial

#194

Post by throwawaylaptop » Tue, Aug 05, 2025, 10:29 PM UTC

leidenfrost wrote: post #182

throwawaylaptop wrote: post #151

Earlier quoted context omitted.

Inaccurate in my opinion. Let's say you eat 2500 calories a day usually. But you want to lose weight so you reduce it to 1800. Except your calories are from pop tarts. If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter. If you ate 1800 calories of pop tarts once a day in 1 hour, you might maintain weight or loose a little. Maybe. If you h…

Insulin control is about managing hunger more than a direct cause for weight. You don't even need to do keto or wacky "just meat" diets to handle insulin. Protein consumption prevents insulin spikes for around 1-2 hours after eating. Also, proteins and fats slow down digestion. Turns out, the good old Mediterranean diet is spot-on for a healthy lifestyle.

? Insulin is not about management of hunger. I think you got your hormones mixed up.

But yes, meat and vegetables is basically what I'd recommend. Never pasta or bread or sugar unless you need help gaining weight.

Re: Ozempic shows anti-aging effects in trial

#195

Post by Levitz » Tue, Aug 05, 2025, 10:31 PM UTC

hinkley wrote: post #124

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

You've got a crowd of people raised in a Calvinist society who think nothing good comes without suffering, you've got people who feel this is a cheat where discipline should win out, and you have a bunch of people who are used to all easy solutions coming with either a bad lottery ticket or externalities on other people/the environment. They can all agree that they're waiting for the other shoe to drop. That said, we…

You've also got the crowd who would argue that there's nothing wrong with being fat in the first place and that are scared of society pressing on this matter again after years of pushback.

Re: Ozempic shows anti-aging effects in trial

#196

Post by mullingitover » Tue, Aug 05, 2025, 10:45 PM UTC

quickthrowman wrote: post #168

mullingitover wrote: post #135

Earlier quoted context omitted.

The cynic in my thinks this will its undoing. Some huge fraction of alcohol profits come from a small portion of drinkers. If these G* peptides help these poor people their drinking under control, it would take a huge wrecking ball to the profits, and thus to the taxes. Can't have that.

Reduced healthcare, policing, and other costs that are paid for with tax dollars from lower alcohol consumption would almost certainly be a net gain over the piddly tax revenue from alcohol consumption sales.

So you're saying it's also going to harm the revenues of the health care industrial complex and the police state? That's not going to help its case.

Re: Ozempic shows anti-aging effects in trial

#197

Post by XorNot » Tue, Aug 05, 2025, 10:51 PM UTC

const_cast wrote: post #103

jfim wrote: post #75

Earlier quoted context omitted.

What are the incentives for people to be fat, out of curiosity? Do you mean farm subsidies for corn, for example?

At a low level, yes, corn, but at a high level: more consumption = more money. Everyone benefits from you being fat. Your doctors, your car manufacturer, food manufacturers, everyone. Except maybe health insurance. But they're not hurt too too much.

There is no doctor on Earth who goes to work and thinks "thank god for fat people or I wouldn't have a business".

There's plenty of doctors and surgeons who wish there were less fat people, because they enormously complicate doing surgery on and managing in hospitals.

Re: Ozempic shows anti-aging effects in trial

#198

Post by parineum » Tue, Aug 05, 2025, 10:56 PM UTC

throwawaylaptop wrote: post #183

tuesdaynight wrote: post #174

Earlier quoted context omitted.

Just scale that solution to millions of people and the comparison will be relevant.

If you told millions of people that bread, sugar, pasta and bread are basically killing them, and to flat out stop eating them.. you probably would help people lose weight (and save many lives too). My dad has finally understood that grains are for people that need help maintain weight or gaining weight. No fat person should ever be eating them.

If I told you billions of people eat bread, sugar and pasta and it wasn't "basically killing them" (whatever that means)...

It's strange to make the culprit of a modern epidemic foods that have been with us for millenia.

Re: Ozempic shows anti-aging effects in trial

#199

Post by throwawaylaptop » Tue, Aug 05, 2025, 11:00 PM UTC

parineum wrote: post #198

throwawaylaptop wrote: post #183

Earlier quoted context omitted.

If you told millions of people that bread, sugar, pasta and bread are basically killing them, and to flat out stop eating them.. you probably would help people lose weight (and save many lives too). My dad has finally understood that grains are for people that need help maintain weight or gaining weight. No fat person should ever be eating them.

If I told you billions of people eat bread, sugar and pasta and it wasn't "basically killing them" (whatever that means)... It's strange to make the culprit of a modern epidemic foods that have been with us for millenia.

Billions of people were not overweight when they ate those things. They did not eat them 3+ times a day.

I said in my other posts.. if someone needs help maintaining or gaining weight, eat those things.

If you are overweight, you should be eating ZERO of them.

"Basically killing them" means whatever the current obesity and type 2 diabetes epidemic means.

Re: Ozempic shows anti-aging effects in trial

#200

Post by throwawaylaptop » Tue, Aug 05, 2025, 11:03 PM UTC

XorNot wrote: post #157

throwawaylaptop wrote: post #142

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

No but its a lot easier for people who've had trouble and gets results, which is all that matters.

Heroine would also help them lose weight also. Maybe cocaine too, but I'm not sure. So it's not "all that matters".

What matters is, are the negative side effects and long term consequences better for you than the alternatives. One of them is "remaining fat". The other is "doing what other people have proven works.. cut all carbs".