This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.
Ozempic shows anti-aging effects in trial
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Re: Ozempic shows anti-aging effects in trial
#12I can't open this link but I wonder if the weight loss or the medicine itself is performing the anti-aging
I was just researching this myself before investing in LLY. For cardiovascular health, they see benefits even with people who are at a healthy BMI, which suggests therapeutic effects beyond just losing weight.
it could also suggest that BMI isn't a great metric, though, as has been in the news often lately.
regardless, thanks too.
Re: Ozempic shows anti-aging effects in trial
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Re: Ozempic shows anti-aging effects in trial
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Re: Ozempic shows anti-aging effects in trial
#15I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
Re: Ozempic shows anti-aging effects in trial
#16I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
Naturally skinny people hate Ozempic for the same reason I know many talented engineers who hate AI coding.
Re: Ozempic shows anti-aging effects in trial
#17I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
Naturally skinny people hate Ozempic for the same reason I know many talented engineers who hate AI coding.
As a talented engineer, I hate AI coding because it doesn't do what it says on the tin. If GLPs made people hallucinate weight loss that wasn't actually happening, I'd be angry about them too.
Re: Ozempic shows anti-aging effects in trial
#18I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
There were even people who felt this way about anesthesia too. To survive in that era, they had to believe that suffering was somehow good for healing (or at least good spiritually) and talked about anesthesia as if it were cheating the natural god-given order.
Re: Ozempic shows anti-aging effects in trial
#19I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
The drug companies are very good at making new drugs with high profit potential look better than they are. I'm worried semaglutides are another fen-phen, Vioxx, Quaaludes, Trovafloxacin or OxyContin.
One thing to watch for is effect size: how big of an anti-aging effect does Ozempic confer relative to other good interventions? Were the subjects doing other solid anti-aging interventions like the Fasting Mimicking Diet (FMD)? If not, the 2 interventions might affect the same pathways with the result that if you are doing FMD, you get no additional benefit from Ozempic.
Fen-phen is particularly interesting here because people reported that not only did it help them lose weight, it gave them more willpower and changed their personalities for the better.
Re: Ozempic shows anti-aging effects in trial
#20I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat.
(From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve.
My opinion is to wait long enough to validate there are no long term harms, but beyond that, yeah, adjust the priors, it could be a modern aspirin.