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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#211

Post by bitexploder »

amelius wrote: post #197
miki123211 wrote: post #115

I swear, Semaglutide is reverse Asbestos. It's something we found and started using to one specific problem, but it later turned out that it has lots of other, extremely wide-ranging consequences. Except that in this case, these consequences are positive.

Semaglutide reduces appetite. Who could have known that eating less will have positive effects? Maybe we should try consuming less in general and see what the effects are. Is there a semaglutide for my shopping habits? Maybe ban ads?

GLP-1 does a lot more than just stomach signaling. It shrinks visceral fat, it's been shown to clear liver fat, and it actually increases mitochondrial efficiency similar to if you were to do endurance work/cardio. There's a lot going on with it. That's kind of what the parent is talking about, all these second-order effects that were not obvious. There is also evidence of down-regulated mTOR signaling and epigenetic protection. And these aren't all just bullshit, big pharma funded studies either.

Re: Semaglutide linked to lower predicted dementia risk

#212

Post by card_zero »

llm_nerd wrote: post #155
outworlder wrote: post #116

Earlier quoted context omitted.

> Fructose can cause fatty liver It is also a large contributor to rising triglycerides levels and uric acid due to the way it is metabolized. Which in turn contributes to high blood pressure. It also makes Acetyl-CoA, which stimulates lipogenesis. It is not even true that it is 'blood sugar invisible'. 30-50% of the fructose is converted in glucose and that's visible. The rest won't be available until you start burn…

>The world didn't suddenly decide to get less active all of a sudden In many ways, yes it did . There is a shocking decline in active calories in every developed country, and it has been exported to the developing world as well. People are astonishingly lazy, on the average. Like, Christ, it's so bad that the recommendation to take a brief, slow walk after meals is revolutionary now. Because the average person just w…

But there's the exercise paradox, which is that it doesn't work.

https://en.wikipedia.org/wiki/Exercise_paradox

Possibly it works in the extremes, but if so, it's modern and unnatural.

Re: Semaglutide linked to lower predicted dementia risk

#213

Post by ambicapter »

SecretDreams wrote: post #207
tokai wrote: post #180

Earlier quoted context omitted.

It wasn't even funded in the way funding a study usually means. That an entity handed over money to a research group. The study was done by employers in their work time for their salary. Its a Novo Nordisk study, and as you say its right there in the open. Pointing an llm against the paper to (wrongly) realize this is a real tragedy of literacy.

I think it rubs plenty of laymen the wrong way to not make it a bit more explicitly known. The world could use a bit less nuance in our headlines these days.

It's never enough for purity tests.

Re: Semaglutide linked to lower predicted dementia risk

#216

Post by amelius »

bitexploder wrote: post #211
amelius wrote: post #197

Earlier quoted context omitted.

Semaglutide reduces appetite. Who could have known that eating less will have positive effects? Maybe we should try consuming less in general and see what the effects are. Is there a semaglutide for my shopping habits? Maybe ban ads?

GLP-1 does a lot more than just stomach signaling. It shrinks visceral fat, it's been shown to clear liver fat, and it actually increases mitochondrial efficiency similar to if you were to do endurance work/cardio. There's a lot going on with it. That's kind of what the parent is talking about, all these second-order effects that were not obvious. There is also evidence of down-regulated mTOR signaling and epigenetic…

> It shrinks visceral fat, it's been shown to clear liver fat

The brain is 60% fat, so I'm not running to the pharmacy yet.

Re: Semaglutide linked to lower predicted dementia risk

#217

Post by eapressoandcats »

SubmarineClub wrote: post #170
eapressoandcats wrote: post #119

Earlier quoted context omitted.

They also clearly have some impacts on metabolism. It’s well known that a challenge with dieting isn’t just eating less, it’s metabolic changes that make weight loss harder. GLP-1’s avoid that.

> metabolic changes that make weight loss harder Which are vastly overblown. I diet every year as part of bodybuilding, at a range of intensities and durations, and have never had issues with sudden metabolic changes that make it harder to lose weight.

That’s very nice for you, but it is a phenomenon that is well documented by research: https://pmc.ncbi.nlm.nih.gov/articles/PMC4989512/

Re: Semaglutide linked to lower predicted dementia risk

#218

Post by eapressoandcats »

gruturo wrote: post #157
eapressoandcats wrote: post #119

Earlier quoted context omitted.

They also clearly have some impacts on metabolism. It’s well known that a challenge with dieting isn’t just eating less, it’s metabolic changes that make weight loss harder. GLP-1’s avoid that.

They do slow down the metabolism, yes. They seem to also act on some reward mechanism - making some stuff (not just food. Alcohol, gambling, porn, smoking, other drugs have anecdotally been reported to feel less attractive / addictive) have a reduced pull on one's will. They also measurably delay gastric emptying - to the point that some medicines, meant to be taken on an empty stomach, are not safe to take within up…

It’s not clear to me that they slow down metabolism consistently, although that does seem to be the effect in some people.

I rather think the opposite is true, that by increasing signals that the body is satiated in many cases it is avoiding a metabolism slowdown caused by hunger.

Re: Semaglutide linked to lower predicted dementia risk

#220

Post by conception »

bityard wrote: post #137
wolfy1993 wrote: post #94

Earlier quoted context omitted.

I'm not sure how the medical establishment ignores this, from my understanding (and please correct me if I'm wrong as I'm not fact checking myself in this moment) - the association between the two is largely linked to vascular dementia (obesity, hypertension, yadda yadda). I think it's hard to argue "The medical establishment" ignores diet as an important factor. I think the reality a lot of the time is doctors presc…

The medical establishment that I have familiarity with (in the US) pretty much only ever treats symptoms, not causes. Don't believe me? Next time you go to see your primary care physician, ask them what you should be doing to lower your risk of whatever malady tends to run in your family. (Diabetes, cancer, dementia, etc.) They're going to stare at you in blank confusion for a few seconds before making some vague sug…

Everyone pretty much knows how to be healthy- good diet (leafy greens, abstain frand exercise. Diets, fads, etc are all just ways people sidestep being slightly uncomfortable rather than limit what they eat and do. Lots of societal things male it harder, eg hyper-palatable foods/ads/overworked/food availability, but that’s the long and short of the root cause.
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