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Semaglutide linked to lower predicted dementia risk
201–210 of 430 posts
Re: Semaglutide linked to lower predicted dementia risk
#202Earlier quoted context omitted.
Not only that but high intakes of added sugars and fast-acting, high-glycemic carbohydrates are linked to an increased risk of cognitive decline and dementia. Excess simple sugars, particularly fructose and sucrose, promote insulin resistance, chronic inflammation, and vascular damage that impair brain function and accelerate neurodegeneration. So with other words, you diet is a major contributing factor here. The me…
I'm not sure how the medical establishment ignores this, from my understanding (and please correct me if I'm wrong as I'm not fact checking myself in this moment) - the association between the two is largely linked to vascular dementia (obesity, hypertension, yadda yadda). I think it's hard to argue "The medical establishment" ignores diet as an important factor. I think the reality a lot of the time is doctors presc…
It's easy to say "just diet ez" and it's hard to "just diet".
If you can administer a treatment as a simple one and done thing, that's alright. If it's a pill you got to take every day, that's pretty bad. More than once a day? Horrible. Why? Because a lot of patients just don't have it in them to take a pill 3 times a day consistently.
If it's purely an "exercise willpower" thing or a "change your lifestyle" thing? You might as well give up.
The medical establishment wants to do things that work. Telling people "go diet" doesn't work. Semaglutide, evidently, does.
Re: Semaglutide linked to lower predicted dementia risk
#203tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…
> This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases You act like all this is hidden, but the title of the article and the list of authors makes this self-evident. > Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline Sure, but the EVOKE studies were focused on something that could b…
You seem to be arguing that people shouldn't be skeptical, by default, of studies of products that are funded by the companies that make the products.
They funded this study as a prospective way of increasing the adoption and market share of their trademarked medication. It deserves skepticism.
Re: Semaglutide linked to lower predicted dementia risk
#204Earlier quoted context omitted.
I’m also active and fat. And to me being active is more important than losing weight; I’d rather continue to do those long 2000kcal bike rides on weekends than having a healthier BMI. I’ve heard stories of my own friends bonking during a ride and I decided that I wanted to err on the side of overeating. So semaglutide doesn’t interest me. You aren’t the only one I’ve heard who started to have no energy after being on…
People bonk because they're not eating enough DURING the ride. I'll eat (actually mostly drink) like 120-200g carbs on longer rides. Record is 700g during a 200km ride. I've seen big guys bonk too. It has very little to do with your BF% (although this is nuanced based on power zones and training 'durability' etc, etc).
Going back to my endurance days, I think people bonk because they aren't adapted. After a year or so of pushing through the bonk, and growing up with hypoglycemia if I didn't eat frequently, I got to where I could start out at 5am on an empty stomach and not eat until noon or later. If I did bonk, I'd sip V-8(yeah, really) and instantly recover.
Re: Semaglutide linked to lower predicted dementia risk
#205Earlier quoted context omitted.
Being a competitive athlete is probably why you have no idea what I'm talking about (and maybe you're not in your 50s). You have a reason to keep your momentum and you are likely more regularly active than I was. Sure I lifted weights, but it was only 2-3 days a week for maybe 6 hours total.
Maybe start lifting weights again? 50 isn't a death sentence; I know a lot of competitive 50s-year-olds.
I'm trying but I've got a toddler and now it seems like every joint hurts. No time to get to a gym and no room for a decent home gym. I did start to do back day again at the Y when we go on the weekend for the pool. We'll see...
Re: Semaglutide linked to lower predicted dementia risk
#206Earlier quoted context omitted.
Not only that but high intakes of added sugars and fast-acting, high-glycemic carbohydrates are linked to an increased risk of cognitive decline and dementia. Excess simple sugars, particularly fructose and sucrose, promote insulin resistance, chronic inflammation, and vascular damage that impair brain function and accelerate neurodegeneration. So with other words, you diet is a major contributing factor here. The me…
> The medical establishment and big pharma simple ignores the fact that the biggest health risk for a human being is the "modern" high sugar diet The medical establishment isn’t ignoring this at all. They’ve been pushing for healthier diets forever. Primary doctors have always been pushing for healthy eating. That doesn’t mean patients welcome the advice or follow it. Everyone knows that eating high sugar diets and b…
> Everyone knows that eating high sugar diets and being overweight is unhealthy.
There is a lack of evidence that the public understands what healthy and healthy effectively mean to their day to day lives,
aside from “looking better”.
Re: Semaglutide linked to lower predicted dementia risk
#207Earlier quoted context omitted.
> This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases You act like all this is hidden, but the title of the article and the list of authors makes this self-evident. > Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline Sure, but the EVOKE studies were focused on something that could b…
It wasn't even funded in the way funding a study usually means. That an entity handed over money to a research group. The study was done by employers in their work time for their salary. Its a Novo Nordisk study, and as you say its right there in the open. Pointing an llm against the paper to (wrongly) realize this is a real tragedy of literacy.
I think it rubs plenty of laymen the wrong way to not make it a bit more explicitly known.
The world could use a bit less nuance in our headlines these days.
Re: Semaglutide linked to lower predicted dementia risk
#208tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…
Not only that but high intakes of added sugars and fast-acting, high-glycemic carbohydrates are linked to an increased risk of cognitive decline and dementia. Excess simple sugars, particularly fructose and sucrose, promote insulin resistance, chronic inflammation, and vascular damage that impair brain function and accelerate neurodegeneration. So with other words, you diet is a major contributing factor here. The me…
They controlled for BMI at least, so they knew that was going to be a common question. BMI is a pretty good proxy for that, and they still said that the majority of the effect came from the compound and not BMI.
Re: Semaglutide linked to lower predicted dementia risk
#209Earlier quoted context omitted.
Speaking as someone who had the same kind of reservations, I think you sound exactly like me, and if I had any advice to my past self, it would be "get on it as early as it's available, start much lower than anyone thinks is sane, and never ever stop". I got a concierge doctor who absolutely evaluates what I ask for skeptically, and pay for my GLP medications out of pocket, so I feel ethically totally comfortable wit…
What downsides have you experienced?
In my experience, basically all downsides can be solved by lowering the dose, and not escalating dosages as fast as the doctors tell you.
Re: Semaglutide linked to lower predicted dementia risk
#210Earlier quoted context omitted.
I don't buy that. You can buy a steak and a potato for two for less than a bag of Doritos. A banana costs far less than a candy bar. A bag of mixed nuts will provide many meals. Price out a bag of rice, a bag of beans, etc. > food companies' only interest is in maximizing profit Pleasing your customers is how profit is maximized. Besides, I bet if you were faced with two stores, one that charges $x for A, and another…
Where are you getting a steak and potato for 2 for less than a bag of Doritos? Is it a 50 lb bag of Doritos?
I can buy the day old steaks for $5-6, and a potato is maybe 50 cents. Doritos are $6.49.
A Hershey's chocolate bar is $3.99-$4.99. A banana is maybe 50 cents.