I had project in college on Prions. Some interesting things I remember: * Kuru (laughing disease) was transmitted from cannibalism. Women and children of the tribe were more likely to contract it because they were more often given the less palatable parts of the bodies, which included brains * Some countries do not trust American cattle because our standards for Prion screening are too low * Kentucky has issues with…
Wow, the Wikipedia page for Kuru says there’s a mutation of the Kuru prion that confers immunity to Kuru. That’s crazy to me, but makes sense from a selection perspective.
Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
171–180 of 195 posts
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#172Earlier quoted context omitted.
We take measures now, for tissues where prions are a possible transmission risk. The article mis-represented that. But: (1) there are only so many resources to go around. Should we be devoting them to vanishingly rare things rather than things that might actually affect you? (2) prions will never be a wildfire plague. They have little or no tranmissive ability, by nature of being absolutely naked protein. One step up…
The example in the article has very little transmissive ability because it grows in the brain and eyes. If there were a respiratory prion disease that could be much different. By nature of being a protein they are simpler and harder to eliminate than bacteria or viruses: > In a particularly vexing twist, prions are also nearly impervious to destruction, even when attacked using a strenuous combination of disinfectant…
As it is, very few proteins in humans have alternate favorable form (by luck or selection?). The exception appears to be the extremely complex and relatively new nervous system of mammals. I'd guess that our immune systems might be another place to look, but that is very highly tested.
Frankly, this seems like a susceptibility that is rare because it is chemically odd not that there is a lack of potential exploitation. Luckily, the range of creatures that share our respiration system far exceeds the range of creatures which share our recently evolved nervous system.
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#173Earlier quoted context omitted.
Nitpick but the step between virus and prion is a viroid; a naked piece of RNA. They mostly exist in plants to my knowledge and are basically the smallest possible infectious disease. The smallest viroids clock in at around 120 base pairs (240 nucleotides).
What's a virion? https://www.theguardian.com/society/2018/dec/10/mysterious-p...
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#174Earlier quoted context omitted.
I don't care whether or not it's a "twist". I care that there is an entire class of pathogen that we don't know how to sterilize a surface of.
You just use bleach and then autoclave: >"combining autoclaving (even at 121 degrees C) with a sodium hydroxide treatment is extremely effective." https://www.ncbi.nlm.nih.gov/pubmed/10658760
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#175Earlier quoted context omitted.
> I've had strange eye problems that my doctor hasn't been able to explain, and I feel like my cognition is declining You could also explain this with low-level heavy metal exposure, e.g. mercury, as well as a large amount of other possibilities :-) I thought hard if I should write this, as a joke and only the above line at first, but here it goes. Having read your second paragraph too, that is pretty much exactly wh…
Can I ask how you were exposed to mercury?
The first thing I found was, after having first dismissed it as esoterics when I found it on the net, that I had a candida problem. Proven by the significant immediate effect of taking Nystatine (anti-fungal) and a doctor confirmed it. Later I even got Fluconazole, an internal antifungal, again with huge effects. Just an aside, funnily enough, the warts on the sole of my feet that every doctor would say were caused by a virus disappeared by 95% after Fluconazole.
Anyway, I learned Candida never is a cause but itself just a symptom, and since I had none of the conditions that are listed in the text books that might cause it I had to continue looking. Heavy metal poisoning was one of the only options that would explain the Candida, but also everything else. And I had only one possible source: amalgam fillings.
When the tests confirmed high levels of mercury in my hair as well as in my urine I still was not completely sure: It was high but not high enough to explain the severity of my issues. The doctor I went to said it was high enough to justify starting chelation, but I must have something else. I had the remaining three fillings removed with special equipment and protection. I had had three or four removed decades earlier without protection, just normal drilling, at the beginning of my CS study, and now something made sense: At the time I had suddenly, out of nowhere and pretty much overnight, developed almost-asthma level pollen allergy, and for half a year I had severe problems with the right leg joint. I never went to a doctor for the joint because the symptoms clearly showed me it was not "physical", I can't explain it with a few words. I also developed severe insomnia and - as I understand now but not at the time - "dumb". I had always been good at math, for example, but suddenly it was a problem. Stuff that today, after all my chelation, again looks very easy to me. I still passed and I was still very good at everything more practical so getting through the study was no problem. At the time I completely ignored all those sudden issues and took it as "that's just live".
Everything started to improve greatly during the first year of chelation, and after the fifth or so DMPS treatment in the following weeks the tissue around my right-side thyroid became very active. That was very curious, because I had had a double-sized right thyroid with a nodule for at least two decades, re-diagnosed just a year prior. Recommendation back then was surgery to get rid of the nodule. The tissues in that area became active after two or three DMPS treatments. I went to the endocrinologist again when I felt nothing else there. He did an ultrasound, and when he was done he started casually looking through his notes and became more and more agitated. He asked me to lie down again and he repeated the ultrasound, right side only this time. At the end the result still was this: Thyroid size nearly completely normal, and the nodule had disappeared completely. That was the point when I actually believed that yes, I had found the source of the problem.
Regarding an even more clear proof for amalgam fillings as the cause:
After about a year the doctor wanted to make an injection in to my buccal mucosa. It's just mucosa, so you don't need any force, but his needle ended up deep inside jaw bone. He found several places where the needle easily penetrated into bone. All those places where where amalgam fillings had been for two or three decades. He injected DMPS and just like in the thyroid area the are began to "work". Very actively. A year later the needle could not penetrate anywhere any more. The jaw remained a very very active area though for years, and it still reacted to chelation. An aside: The are had been OPG x-rayed a few times in the years before because I had finally gotten my crooked teeth fixed and jaw extension surgery too (now I have perfect bite and teeth, wonderful!!!). No doctor ever saw anything in my jaw. One wasn't sure about seeing a tiny shadow near one root - the one where I had the most issues and that was the most active later during chelation - but didn't take it serious enough and didn't follow up (when patients don't complain why would you if it's so subtle). But bone that can be penetrated by a needle easily is very broken. This shows how much (more) broken something has to be to show up even in an OPG x-ray.
My doctor never found anything else and now he too thinks that the only problem there ever was were the amalgam fillings. A lot - a lot! - of very interesting stuff happened to me, the chelators only paved the way out and started it, 99% of the actual work was done by my body (most chelators only work in extracellular space anyway). For example, there were three months of nightly 3-4 am kidney pain, but after the nephrologist found that despite elevated protein levels in urine there was no sign of kidney disease I didn't worry about it. It fit into the pattern of stuff happening at various times all over my body and my brain, a new phase starting every few months in another area of the body. For those three kidney pain months I simply got up when it started at 3 am or so, went to bed when it stopped at 5 am and slept until 10 and still got my sleep. No problem.
Even tough I'm a CS person, I actually have a background not in medicine, but (for fun and out of interest) I've also have many courses in biology, chemistry, org.chemistry, biochemistry, anatomy, physiology, neuroscience, several courses in each. I don't care about pathologies, I only wanted to understand the basics of biology and life and of human physiology.
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#176Slightly worrying given that I had a cataract operation in my mid-30s. OTOH, I suspect I should be far more worried about the health impact of filthy diesel.
Isn't cataract surgery removing something, only? FWIW, both my parents had cataracts removed, and my father who'd worn eyeglasses since the 1940's said he'd never seen better in his life. So, chin up.
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#177Slightly worrying given that I had a cataract operation in my mid-30s. OTOH, I suspect I should be far more worried about the health impact of filthy diesel.
the odds of this are about zero. the donor would have to have CJD, which is already exceedingly rare.
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#178Earlier quoted context omitted.
>Are you saying that the more complicated things are, the more it hints at a simulation? No, I'm saying that the fact that we can see down to a subatomic level which adds considerable complexity to a hypothetical simulation is not evidence that it is impossible that we live in a simulation. If you tried to describe a 2018 smartphone to Konrad Zuse in 1936 he'd have thought you were either quite mad or a science ficti…
> No, I'm saying that the fact that we can see down to a subatomic level which adds considerable complexity to a hypothetical simulation is not evidence that it is impossible that we live in a simulation. Okay, but I suggest you be a bit more careful with wording in the future. "These are both somewhat my logic" made it sound like the complexity was reinforcing the idea, rather than merely not completely disproving t…
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#179Prion disease is exceedingly rare. CJD is the most common, with an incidence of 1 per 1,000,000 person-years worldwide, inclusive of all transmission vectors (including medical procedures). Iatrogenic transmission is a rarer subset still: the riskiest transplants (with respect to CJD) are in the central nervous system. The UK tracked their transmission rates from 1970 to 2003 (a long period is needed because surgical…
There is a great hypothesis that I remember my dad telling me recently, although I can't remember where he heard it from, that the reason that prion disease is so rare in humans is because we're, historically, very cannibalistic, so resistance to prions was heavily selected for.
Re: Prions, Nearly Indestructible and Universally Lethal, Seed the Eyes of Victims
#180I had project in college on Prions. Some interesting things I remember: * Kuru (laughing disease) was transmitted from cannibalism. Women and children of the tribe were more likely to contract it because they were more often given the less palatable parts of the bodies, which included brains * Some countries do not trust American cattle because our standards for Prion screening are too low * Kentucky has issues with…
A few questions: * Do we have a good grasp on the number of prions in the world? My recollection from when MadCow became a big thing in the late 90s was that prions weren't even looked for and were hard to find as a general rule, but that was 20+ years ago. Might there be many common-but-harmless prions that we haven't even noticed? * WHY is brain consumption (both in humans and in animals) such a source of prions? W…
People talk about Mad Cow, Kuru, Creutzfeldt-Jacobs, Chronic Wasting Disease, Scrapie, and a dozen other diseases like they are not all manifestations of the same underlying problem with PRNP gene variants.