161–170 of 211 posts
Earlier quoted context omitted.
An interesting FYI is a comment made by Peter Attia on his podcast. He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss. They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects. It seems like GLP1, even in skinny patients (…
It shouldn't make any difference where you pin it, it's systemic it just has to be administered subcutaneously because it's a peptide and it isn't orally active. Don't listen to these YouTubers about health and fitness, most of them are clueless
Earlier quoted context omitted.
An interesting FYI is a comment made by Peter Attia on his podcast. He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss. They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects. It seems like GLP1, even in skinny patients (…
It shouldn't make any difference where you pin it, it's systemic it just has to be administered subcutaneously because it's a peptide and it isn't orally active. Don't listen to these YouTubers about health and fitness, most of them are clueless
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
Many Americans drive a car every day, even though ~40k people a year die in car accidents. Why? Because the benefits outweigh the risk. (my partner is on a GLP-1, and lost ~25 lbs in 3 months)
no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird
Compounded GLP-1s are still floating around in the US
I’ve never been extremely overweight but I hit a point where I had 30 pounds to lose, despite my height, and I can’t deal with the hunger amidst all my other life stresses.
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
I am sort of in your boat in seeing what may come. There are a few very rare conditions but the benefits seem to out weigh (ha, I will take the pun!) The down sides. While it might mean the incident rare of some things goes up, those that it reduces are far more impactful and where far more likely to have mortality issues. Sort of like how Chemotherapy is poisonous but potential has better long term odds, only chemo…
Which is ironic because someone at Microsoft once called the GPL "cancer".
Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.
Several members of my family are into glp-1 both for glucose control and for weight loss. Taking different brands (wegovy, ozempic and others.) They all mention.th terrible secondary effects when you eat something "forbidden" (tacos, cake or icecream e.g.) . Also It causes constipation apparently, which for most of them is not that much of an issue, but given that I've IBS-C, I'm happy to not have to take it.
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Some people stop using it due to personality changes.
Yeah I stopped because I didn't like the way it made me feel. I needed it because my blood sugar was way too high and it helped me drop close to 60 pounds in 6-8 months, but I did not like how it made me feel and I lost more muscle than I was happy with. I've gained about 15-20 pounds back, but I'm now much healthier overall. I like how my brain works and I didn't like something affecting or changing that because I c…
I'm not dismissing your overall point. I minimize my use of Adderall for that very reason.
> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong…
Interesting that GLP-1s might have different effects on cancer _incidence_ vs. cancer _survival_. A different study "GLP-1 Receptor Agonists and the Risk of Thyroid Cancer" was published in the Diabates Care journal in February 2023* The conclusion of the 2023 study: "we found increased risk of all thyroid cancer and medullary thyroid cancer with use of GLP-1 RA, in particular after 1–3 years of treatment." I wonder…
Below a table, it says "adjusted for social deprivation index, hypo- and hyperthyroidism, and use of other antidiabetic drugs..." -- but nothing about obesity.
What if the GLP-1-prescribed patients tended to be more obese?
no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird
(This refers to the U.S. Some other countries have more generics available.)