Earlier quoted context omitted.
Well that'll teach that poor bastard to ask a question here, good job!
Is it possible to ask a question in a patronising way?
I don't know, is it?
Ketamine has 'fast-acting benefits' for depression
161–170 of 215 posts
Re: Ketamine has 'fast-acting benefits' for depression
#162Re: Ketamine has 'fast-acting benefits' for depression
#163Earlier quoted context omitted.
Mowing up a gram of ket every weekend is going to kill any therapeutic benefits you get from it. That's different to a small dose once a month in a medically supervised environment. One big problem with recreational drugs (from personal experience) is that you get conditioned to them if you overuse them, then life seems sort of shit without them. With MDMA, you can even permanently lose the magic if you take too much…
Pretty sure the permanent damage thing is mostly a myth except you talk about a Seratonin syndrome which however doesn't increase in probability with the frequency you take it (mdma) I am not sure what the medical amount for ketamin would be, but i would think the average is more around 100mg a month (and using about every 3) within my circle. Which is not exactly that much. As far as I know are long term studies sti…
So the levels of neurotoxicity for MDMA are not known. It's almost certainly neurotoxic to some degree but not any where near the levels purported by that study that used massive amounts of meth on rats (remember alcohol is also neurotoxic).
However, over use can certainly habituate a user to it such that it "loses its magic" as in the psychoactive effect is far far far less than what it originally was.
Re: Ketamine has 'fast-acting benefits' for depression
#164Earlier quoted context omitted.
Imho, dissos are for short term depression fixing, you need them psychedelics to open your mind for long term.
Seconded. Try mushrooms, acid, or DMT. Maybe mushrooms if it’s your first time. Watch some trip report videos on YouTube to get an idea of what you’re in for. It doesn’t “cure” depression... it’s more like it gives you an audience with... something... that then tells you exactly what you need to know about life, the universe, and everything. It’s up to you to then make sense of it, integrate, and execute, which can i…
Ketamine is itself a psychedelic.
With all psychedelics, it's very important to integrate the insights you gain during the experience back in to your ordinary life, or they are likely to fade.
It's also important to use psychedelics constructively: with a constructive intention, with an experienced sitter that you trust, in a safe setting. There are lots of other things one can do to prepare. I'd recommend reading "The Secret Chief Revealed" and "The Psychedelic Explorer's Guide".[1][2]
[1] - https://www.amazon.com/Secret-Chief-Revealed-Myron-Stolaroff...
[2] - https://www.amazon.com/Psychedelic-Explorers-Guide-Therapeut...
Re: Ketamine has 'fast-acting benefits' for depression
#165Earlier quoted context omitted.
Doesn't ketamine stimulate growth in the same areas of the brain that exercise does, and does therapy prescribe routine daily exercise? I can imagine there being a great short term benefit to ketamine, as people who are severely depressed can't exercise due to the depression. Has there been any mention switching from ketamine to daily exercise, or doing both?
How often did you have depression? Especially major depressive episodes where you have trouble to even motivate yourself to move out of the bed or do ANYTHING but just "exist" and even that seems hard? If the answer is zero (which I think it is) do those who have it a favor and shut up. Depression is hard enough without "you just have to exercise, huahua" comments.
> If the answer is zero (which I think it is) do those who have it a favor and shut up
I get where you're coming from with this response - if you haven't been there, there is just no way you can understand how desperately bleak things can become.
But if someone is ignorant about mental health, why not try to educate that tell them to "shut up"?
We need to talk about these things, not humiliate and shut down anyone who doesn't understand.
Re: Ketamine has 'fast-acting benefits' for depression
#166I've posted this in other ketamine news stories before, but I'm offering it as a firsthand testimonial here. Ketamine was both the best and most depressing depression treatment option I've ever tried. Within a couple of weeks after having had the initial round of six treatments in two weeks, I was the most functional and productive human being I've _ever_ been - things that used to be impossible or utterly agonizing…
Ketamine and its analogs are known to have a rapidly developing and profoundly durable (some even say permanent) tolerance, and I find this is often glossed over, especially when studies don't evaluate it over a long enough time period I think Ketamine itself isn't a real solution but hopefully some of the isolated metabolites will be
> tolerance. I find this is often glossed over
This was specifically and prominently addressed by the article:
>> However, at 25 days the effects had levelled out.
>> The study's authors suggest it could offer an effective rapid treatment for people severely depressed and at imminent risk of suicide and could help in the initial stages of treatment, as most anti-depressants take four to six weeks to become fully effective.
They see it as a bridge treatment which is temporarily useful until anti-depressants kick in. Because, as it said, after 25 days the benefits begin diminishing... which sounds perfectly reasonable and has the added benefit of reducing the risks of addiction.
Re: Ketamine has 'fast-acting benefits' for depression
#167Earlier quoted context omitted.
> We pay $375 for a 40-minute infusion Having no knowledge on the matter, what's the price comparison to just buying ketamine illegally and taking it without a doctor's help? Depression is like (or possibly is ) a form of chronic pain. People suffering from it severely might be willing to do anything for relief. Here's good information that a currently-illegal drug can help but if you want to do it legally you might…
Ket will set you back anywhere from $50-$150 per gram, depending on where in the world you are, and is of varying quality. It looks like they're using up to 1/2 a gram for treatment. I think the most of that $375 goes towards staffing costs, rather than the drug itself. Ketamine though legitimate channels costs about $5-$10 per gram from what I've heard.
My doctor uses a sedative also to make sure you don't freak out during the treatment. I think most doctors do this. You need to factor that into the cost too.
Re: Ketamine has 'fast-acting benefits' for depression
#168My girlfriend receives ketamine treatment for her depression, so I’ve the results first hand. It’s truly astounding. She’s seen more improvement from the ketamine than from a decade of psychotherapy and traditional psychopharmacology. The only downside is the cost (it’s not covered by insurance) and the potential that there are long term side effects that have yet to be discovered. We pay $375 for a 40-minute infusio…
> We pay $375 for a 40-minute infusion Having no knowledge on the matter, what's the price comparison to just buying ketamine illegally and taking it without a doctor's help? Depression is like (or possibly is ) a form of chronic pain. People suffering from it severely might be willing to do anything for relief. Here's good information that a currently-illegal drug can help but if you want to do it legally you might…
> Having no knowledge on the matter, what's the price comparison to just buying ketamine illegally and taking it without a doctor's help?
It's way cheaper on the black market. The actual cost of manufacture isn't very high, and I don't think it falls under any patents needing licensing. Probably you're mostly paying for the labor.
Re: Ketamine has 'fast-acting benefits' for depression
#169Earlier quoted context omitted.
Ket will set you back anywhere from $50-$150 per gram, depending on where in the world you are, and is of varying quality. It looks like they're using up to 1/2 a gram for treatment. I think the most of that $375 goes towards staffing costs, rather than the drug itself. Ketamine though legitimate channels costs about $5-$10 per gram from what I've heard.
My doctor uses a sedative also to make sure you don't freak out during the treatment. I think most doctors do this. You need to factor that into the cost too.
Sedatives (probably benzodiazepines) are also very inexpensive (on the order of less than a dollar) compared to the $375 figure.
Re: Ketamine has 'fast-acting benefits' for depression
#170Ketamine is an anesthetic. Has anyone compared it to e.g. ibuprofen for this use case? Ibuprofen works very well for me when experiencing depressive symptoms. I'm down to about 2h max per depressive episode (logged at 10-30 depressing thoughts per minute, compared to none after). Mechanism intuitively "feels" inflammatory and looking at my logs seems related to exhaustion due to over-productivity, lack of rest, etc.
https://www.psychologicalscience.org/news/releases/experienc... Ibuprofen actually does work, believe it or not.
I appreciate the link! I find this all very fascinating.