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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

141–150 of 251 posts

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#141
post #71

Earlier quoted context omitted.

Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

Naproxen / Aleve?

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#142
post #4

This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.

I've been suffering from migraines since ~14yo, to the point that I can wake up and know if I'm going to get a migraine or not. I take naproxen, if I know I'll get a migraine I'll take 1x250mg, if I have a migraine I take 2-3x250mg depending on how severe it is. Cause of mine is generally lack of sleep when stressed so I make sure to sleep properly and don't let myself get stressed out, so I only get migraines ~once…

Just as a side hint: did you ever get your vitamin levels checked? I had migraines with aura a couple of times a week until I got a full vitamine check up on B vitamines and Q10. I had a huge lack of B12 plus Q10. I managed to compensate with supplements (the expensive ones from the pharmacy) and didn't have migraine now in 3 months. Might be worth looking into :)

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#143
I've had frequent migraines all my life (although it's much better now) and ibuprofen is the only thing that works.

As a kid, I would take 200mg whenever I had a headache. To this day, I still haven't switched to the adult dose of 400mg. I think a lot of people will find ibuprofen to be effective even at lower doses.

I'm sad to find that ibuorofen has so many negative side effects. For me, it's been a miracle drug. I rarely feel as good as I do after taking it. I generally feel happier, with clearer thoughts and less anxiety.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#144
post #112

Earlier quoted context omitted.

My guess is the down vote comes from someone thinking your comment sounds like you don't have any children or know what you are talking about. You don't give ibuprofen for pain during a fever, though doctors will say it can help because often times the source of the fever will cause pain like an ear infection or strep throat, you give it to reduce the temperature. There is a serious risk of seizure in children if you…

Why do you not help your kids when they are in pain?! This is truly shocking to me, it is definitely a cruel and inhumane sentiment.

I am sure there are nuances to your statement that get lost in the short text so I assume that you don't mean it quite as hyperbolic as it comes across but my immediate reaction to that sentence is: you can't protect your child from pain forever -- physical or emotional. How will they learn to handle it if they aren't exposed to it gradually?

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#145
post #71

Earlier quoted context omitted.

Sounds like the industry responding with "we cant really know guys, right?" I'm throwing away my Advil right now. Screw that.

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#147
post #35

Just had a kidney stone problem—first for me, quite painful experience. My ibuprofen dosage is 800mg every 8 hours, as needed. I had little choice. “Sustained” is the keyword of the study here. On another note, maybe this will drive alternative treatments such as CBD/marijuana for those who need to sustain their pain relief.

I’ve suffered from kidney stones off and on for years. Here’s what helps.

Make sure you’re drinking enough water. 2 gallons per day minimum. If your pee isn’t clear, you’re not drinking enough. I add flavor packets to mine to make it more palatable. I carry a water bottle with me all day. Went from an attack once a month to once a year.

Mix pain meds. It’s perfectly healthy. Don’t take 800 mg of ibuprofen. Take a normal dose of ibuprofen (200 mg) and a normal dose of tylenol. Then tylenol and naproxen. Then naproxen and aspirin.

Rotate them so you don’t get a megadose of any one. Each time take one that treats pain and one that treats pain and inflammation.

A low dose of multiple drugs works way better than a large dose of just one. You’ll find yourself taking a lot less medicine overall and you won’t be in as much pain.

Buy an electic heating pad and apply it to your lower back as soon as the symptoms start.

Hope this helps.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#148
post #71

Earlier quoted context omitted.

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

Naproxen / Aleve?

The naproxen molecule is very similar to ibuprofen, so I expect it would have similar effects.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#149
post #22

Earlier quoted context omitted.

Clearly you have never been in the USMC. In hind sight it was pretty stupid but I have taken up to 1600mg per day for several days/ weeks in a row. We pretty much call the 800mg tablets grunt candy.

Same in the Army. Headache, 800mg. Arm blown off, 800mg. Sigh.

And don't forget to drink water soldier!

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#150
From the paper:[0]

> The so-called “over-the-counter” mild analgesics (hereafter simply called “analgesics”), such as acetaminophen/paracetamol, acetylsalicylic acid/aspirin, and ibuprofen, are among the most commonly used pharmaceutical compounds worldwide (6, 7). Increasing evidence from recent years shows that exposure to analgesics can generate negative endocrine and reproductive effects during fetal life (6). Nonetheless, no in-depth studies have analyzed the effect of mild analgesics on the human pituitary–gonadal axis. In this context, ibuprofen is especially interesting because of its increasing use in the general population and in particular by elite athletes (8⇓⇓⇓–12).

So now I wonder about acetaminophen/paracetamol, and aspirin. And naproxen. Maybe that's why I need testosterone supplementation. In addition to the fact that I'm old.

0) https://www.pnas.org/content/115/4/E715.long

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