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Long Covid: major findings, mechanisms and recommendations

nature.com

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Re: Long Covid: major findings, mechanisms and recommendations

#131

Post by nerdponx »

EMM_386 wrote: post #14

I was diangosed with syncope on standing shortly after getting Covid (the first time). I'd never experienced anything like this before in my life, but suddenly the world would fade to black if I stood up too soon from a reclined position. I also experienced intense brain fog. I actually scheduled a doctors appointment specifically for "brain fog" at the time and they were confused as to what I was explaining. All I c…

It would be nice if the medical profession actually had some kind of handle on brain fog. It can be debilitating.

Re: Long Covid: major findings, mechanisms and recommendations

#132

Post by nerdponx »

d_sem wrote: post #7

Fascinating read. I'm glad to see these findings get serious attention by researchers. It was really frustrating getting dismissed by my local physician when sharing symptoms like sugar sensitivity, fatigue, and focus issues. It was like being perpetually tipsy for months. It was a big shock as a knowledge worker to have to relearn how focus. I hope they further study vaccines as well. In my anecdotal case my long co…

Meanwhile long Covid sounds more or less like the chronic health problems I've had since ~2014 (which nearly ruined my life).

In my case it seems to be autoimmune, so maybe that's part of what's happening with long Covid as well.

There are various protocols (mostly dietary) that attempt to help, under names like "Autoimmune Paleo". It all seems under-studied. Maybe now that millions of people are having the same symptoms, there might be some movement on it.

That or GSK will come up with a drug that doesn't really help and has a lot of side effects but the medical community will declare the problem solved and move on.

Re: Long Covid: major findings, mechanisms and recommendations

#133

Post by dontlaugh »

Izkata wrote: post #82
twawaaay wrote: post #25

Earlier quoted context omitted.

I feel for you. This is such a strange virus. My whole family got covid so I expected to be next. But I only needed to take 2 days off at work and I paused my training for just 3 days and was almost back to my normal HR/pace in less than a week since I got first symptoms. It took me 3 more weeks before I started getting negative test results.

> This is such a strange virus. This effect was previously known as post-viral fatigue. It's not unique to covid.

What is unusual is how long it lasts and, to some extent, how severe it can be.

Re: Long Covid: major findings, mechanisms and recommendations

#134

Post by karim79 »

I tested positive in mid-February 2022. I had been double vaxxed with the second one administered on Christmas Eve of 2021.

The symptoms started with swollen red feet (which I somehow dismissed) followed by really strange vivid dreams that night. The following day I woke up in the morning and was unusually tired, and so took a nap on the couch and silenced my phone for a while.

I was feeling relatively normal post-nap. Later in the evening before sleep time I took my dog for a walk. It was -2C outside and the air felt warm as it hit my face, and as I was walking the stairs back up into my flat (on the third floor) my legs felt abnormally weak, and at that stage I took a test, which was a solid positive.

That same night I contracted a high fever and informed all my co-workers. I don't recall having had a virus where I would literally spend minutes/hours self-negotiating to get a glass of water, or go to the toilet, and for the first four-five days I had no appetite whatsoever. I was in and out of sleep for that period and fully devoid of energy for about ten days. I tested negative on the ninth days.

For the next three weeks, I had almost no energy, little ability to concentrate - overall it took about a month to get back on my feet and about two months to feel "normal" again.

Overall, I think there's something to long covid, but I'm no doctor.

Re: Long Covid: major findings, mechanisms and recommendations

#135

Post by dTal »

RandomWorker wrote: post #26
thewizardofaus wrote: post #10

Covid fatigue is no joke. As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep. I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal". The most frustrating thing is…

That sucks. My experience was to get back to training fairly soon (2 weeks after fever went away). After that training session I knew I should rest more and took an additional 2 weeks off. Then built back up my regular training starting at 10% volume and increasing at 10% increases each week. After 3 months I was back to regular volume. My suggestion is that everyone take at least two weeks off, and build up volume v…

If you were "training" 2 weeks after the fever went away, congratulations - you didn't have long covid.

You cannot exercise your way out of Long Covid, or other postviral fatigue syndromes - it presents identically to Chronic Fatigue Syndrome. Any attempt to exercise - even something as small as a short walk, or in severe cases merely taking a shower - results in a hard crash that feels completely unlike exercise fatigue, and can effectively confine you to bed for days. And every time you provoke a crash, you set back your recovery, potentially permanently. And you can't really tell by feel what your limits are, you just have to work it out analytically and be conservative. And the whole time, your brain feels like mush.

It's really no joke.

Re: Long Covid: major findings, mechanisms and recommendations

#136

Post by yratsor »

My experience is that after two doses of Pfizer I had unexpected positive side effects, such as increased performance (e.g. I can do a lot more push-ups) and my allergy symptoms (runny nose) have significantly decreased. Do you know any research on unexpected positive side effects?

Re: Long Covid: major findings, mechanisms and recommendations

#137

Post by Invictus0 »

SergeAx wrote: post #127
thewizardofaus wrote: post #10

Covid fatigue is no joke. As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep. I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal". The most frustrating thing is…

> walk longer than a minute without needing to lay down for the rest of the day and sleep I'm sorry, do you mean it literally?

Not OP but yes, literally. A friend of mine has long covid, used to run marathons. For a time he was unable to go up the stairs without crashing hard.

Re: Long Covid: major findings, mechanisms and recommendations

#138

Post by incrudible »

Animats wrote: post #124
dehrmann wrote: post #53

Earlier quoted context omitted.

> 30% - 40% of the population disabled? That assumes likelihood of getting long covid doesn't drop after successive infections.

> That assumes likelihood of getting long COVID doesn't drop after successive infections. It's not looking good. December 2022 study [1][2]: "The risk of hospitalization, organ damage, and death rises markedly with repeat COVID-19 infection. Assistant professor of medicine Amy Barczak shared a Nature study that used data from the Veteran’s Administration to assess the cumulative risk of post-infection effects in peop…

People always cite the Veterans affair study to support the claim that reinfections are more severe, without citing this paragraph that makes it clear that this study can not support that claim:

Our analyses should not be interpreted as an assessment of severity of a second infection versus that of a first infection, nor should they be interpreted as an examination of the risks of adverse health outcomes after a second infection compared to risks incurred after a first infection.

I am not aware of any study that supports the claim that reinfections are worse.

Re: Long Covid: major findings, mechanisms and recommendations

#139

Post by PaulKeeble »

throw_nbvc1234 wrote: post #50
Animats wrote: post #45

This is really bad. Important points: * About 10% of people getting COVID get some form of long COVID. * There's long term damage. At least years. Maybe permanent in some cases. * You can get COVID more than once.[1] Somewhere above 6-10% of infections are re-infections, and that number increases over time. Immunity seems to last 3-18 months. What is this going to look like in 5 years? 30% - 40% of the population dis…

You're missing the variable of how severe the long covid symptoms are. If it's 10% long covid and 10% of those are serious it's only 1% of total covid cases. Unless you're using a loose definition of "disabled".

According to the ONS data 75% are impacted on day to day basis by their Long Covid and 25% are severely impacted. This likely maps to Mild, Moderate and Severe from ME/CFS definitions roughly. Its a lot of people disabled and an awful lot very severely disabled.

Re: Long Covid: major findings, mechanisms and recommendations

#140

Post by seydor »

EMM_386 wrote: post #14

I was diangosed with syncope on standing shortly after getting Covid (the first time). I'd never experienced anything like this before in my life, but suddenly the world would fade to black if I stood up too soon from a reclined position. I also experienced intense brain fog. I actually scheduled a doctors appointment specifically for "brain fog" at the time and they were confused as to what I was explaining. All I c…

Maybe you just lost weight during covid?
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