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Long Covid: major findings, mechanisms and recommendations

nature.com

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Re: Long Covid: major findings, mechanisms and recommendations

#121

Post by nikolay »

wkat4242 wrote: post #108
nikolay wrote: post #107

COVID-19 is no joke. I know people want to move on with their lives, but people should stick to N95/KN-95/KF-94/FFP2/FFP3 masks for the time being unless we want to create a massive health care crisis and ruin the global economy as the if people get reinfected every few months, this would be imminent!

Where I live people do get reinfected every few months because masks are gone, and this is not a major problem. Most of the long COVID cases stem from the first and second waves here.

We are talking long-term harm - it's too early to say people are just fine.

Re: Long Covid: major findings, mechanisms and recommendations

#122

Post by nikolay »

threadweaver34 wrote: post #111
nikolay wrote: post #107

COVID-19 is no joke. I know people want to move on with their lives, but people should stick to N95/KN-95/KF-94/FFP2/FFP3 masks for the time being unless we want to create a massive health care crisis and ruin the global economy as the if people get reinfected every few months, this would be imminent!

> people should stick to N95/KN-95/KF-94/FFP2/FFP3 masks for the time being Now that we have a vaccine and a bivalent booster, realize that you're suggesting masking for at least another 5 years. You said this, but it also has to be N95 at this point with how contagious it is. > people get reinfected every few months The realistic estimates are more like every year.

The boosters do almost nothing about XBB.1.5 and the upcoming strains - this is evolution at play! You can't use the same strategy we've used for the flu - this virus mutates much faster as it infects a lot more people.

Re: Long Covid: major findings, mechanisms and recommendations

#123

Post by weaksauce »

nradov wrote: post #99
weaksauce wrote: post #23

Earlier quoted context omitted.

> And if unlucky, you can greatly affect the number of times you get infected through precautions. not to mention that even if you do get sick it's a continuum of sickness. you can get a little sick by getting a little bit of the virus and having an immune system that can handle that with ease. you can have the same immune system but spent too much time with your SO that got covid and was giving you a huge viral load…

There is no reliable data to support your claim of a continuum of sickness based on the inoculum dose. https://doi.org/10.1093/cid/ciab903

you certainly must be kidding right? there might be a dearth of data on that because of the nature of ethics/how hard that is to test but if you are aware of the basic human immune system response to pathogens you would know that it's a few equations of things at a basic level.

virus particles are not smart... they infect cells and make more virus particles they don't have a mechanism that says ok slow down we infected enough to make the host sick... they just infect non-infected cells that are available to infect. for a thought experiment even if you took the replication aspect out of it the more virus cells in your body infecting more cells in your body it would make you sicker. counting in the fact that every infected cell will create more virus particles and a stronger first dose of virus particles that creates those factories would make you sicker all other things equal.

at a basic level you have some differential equations going: the B cells make the antibodies that kill the free virus particles. the T cells kill infected cells and inform the B cells to make specific antibodies.

just because this data is hard to obtain from empirical means doesn't mean that the basics of biology are that divergent from reality.

Re: Long Covid: major findings, mechanisms and recommendations

#124

Post by Animats »

dehrmann wrote: post #53
Animats wrote: post #45

This is really bad. Important points: * About 10% of people getting COVID get some form of long COVID. * There's long term damage. At least years. Maybe permanent in some cases. * You can get COVID more than once.[1] Somewhere above 6-10% of infections are re-infections, and that number increases over time. Immunity seems to last 3-18 months. What is this going to look like in 5 years? 30% - 40% of the population dis…

> 30% - 40% of the population disabled? That assumes likelihood of getting long covid doesn't drop after successive infections.

> That assumes likelihood of getting long COVID doesn't drop after successive infections.

It's not looking good. December 2022 study [1][2]:

"The risk of hospitalization, organ damage, and death rises markedly with repeat COVID-19 infection. Assistant professor of medicine Amy Barczak shared a Nature study that used data from the Veteran’s Administration to assess the cumulative risk of post-infection effects in people with one, two, and three or more SARS-CoV-2 infections, as compared to noninfected controls. The data show a consistent pattern of increased likelihood of hospitalization, cardiovascular effects, clotting and other blood disorders, diabetes, fatigue, gastrointestinal distress, kidney damage, mental health effects such as depression, musculoskeletal damage, neurological deficits, and pulmonary damage with each episode. Prior infection does not change the course of disease in subsequent infections, just the risk of severe complications."

[1] https://www.harvardmagazine.com/2022/12/covid-reinfection

[2] https://www.nature.com/articles/s41591-022-02051-3

Re: Long Covid: major findings, mechanisms and recommendations

#125

Post by [deleted] »

nradov wrote: post #105
eismcc wrote: post #56

Earlier quoted context omitted.

I found popular ones on Amazon. I tried it because of doing research on my high numbers for Epstein-Barr (aka mono). I found via NIH papers that liver issues are common with mono patients so I figured I could be having that since there were no other obvious blood results. I had Covid beforehand and when I had extreme fatigue I had the mono tests done. The EBV numbers were off the charts and then I found some NIH pape…

What is the active ingredient of that supplement?

[deleted]

Re: Long Covid: major findings, mechanisms and recommendations

#126

Post by ImHereToVote »

jandrewrogers wrote: post #116
Animats wrote: post #45

This is really bad. Important points: * About 10% of people getting COVID get some form of long COVID. * There's long term damage. At least years. Maybe permanent in some cases. * You can get COVID more than once.[1] Somewhere above 6-10% of infections are re-infections, and that number increases over time. Immunity seems to last 3-18 months. What is this going to look like in 5 years? 30% - 40% of the population dis…

I’ve had COVID multiple times — I collect variants like Pokémon cards. The first one (pre-vaccine!) was nasty with a few lingering effects that went away after a month, the last was asymptomatic. In everyone I know that has had multiple infections — which is a lot of people these days — subsequent infections are much less consequential than the last, including lingering effects. This is what you would generally expec…

Looks like we got a reader. What are you reading for?

Re: Long Covid: major findings, mechanisms and recommendations

#127

Post by SergeAx »

thewizardofaus wrote: post #10

Covid fatigue is no joke. As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep. I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal". The most frustrating thing is…

> walk longer than a minute without needing to lay down for the rest of the day and sleep

I'm sorry, do you mean it literally?

Re: Long Covid: major findings, mechanisms and recommendations

#128

Post by wesapien »

I got Covid in November and I was fully jabbed but no boost. As soon as I felt something different, I performed nasal rinsing and added Iodine to it. I did this for the first 5 days twice a day. This was the crucial thing for me. I felt fine after the 4th day but still tested positive. I tested negative on the 10th day and I ended my self quarantine. Before that, I was already taking Zinc, Vitamin D3, Vitamin C for years. I feel normal and I'm very glad that whatever I did before and during infection seemed to have help me recover fast.

Re: Long Covid: major findings, mechanisms and recommendations

#129

Post by tasuki »

wesapien wrote: post #128

I got Covid in November and I was fully jabbed but no boost. As soon as I felt something different, I performed nasal rinsing and added Iodine to it. I did this for the first 5 days twice a day. This was the crucial thing for me. I felt fine after the 4th day but still tested positive. I tested negative on the 10th day and I ended my self quarantine. Before that, I was already taking Zinc, Vitamin D3, Vitamin C for y…

How do you know that what you did helped you recover fast?

As a data point, I also had Covid and also recovered fast, without any of these.

Re: Long Covid: major findings, mechanisms and recommendations

#130

Post by shawabawa3 »

moistly wrote: post #92
godelski wrote: post #21

Earlier quoted context omitted.

Maybe I'm being generous to the parent, but I also would like a comparison to the flu. Not because I don't believe covid is significantly worse (when I got it, it was way worse than the flu), but because I don't have a medical background and it is difficult to contextualize the actual risks here without some baseline where I have a decent intuition already built around. But where I disagree with the parent is the nee…

But have you actually had the flu? I ask, because most people say “oh, I had the flu” when in actuality they just had a common cold. The flu, the real flu, knocks you on the ass so hard that you actively start considering that death is a possibility and that heading over to the hospital would be a good idea. I’ve had the flu perhaps twice. Once as a child, once in my early 50s. The latter completely recalibrated my u…

Note that like COVID the flu has varying severity

You can catch the flu and have not much more than a cold or even be asymptomatic, then your grandma catches it off you and died from it

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