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Long Covid: major findings, mechanisms and recommendations

nature.com

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Re: Long Covid: major findings, mechanisms and recommendations

#111

Post by threadweaver34 »

nikolay wrote: post #107

COVID-19 is no joke. I know people want to move on with their lives, but people should stick to N95/KN-95/KF-94/FFP2/FFP3 masks for the time being unless we want to create a massive health care crisis and ruin the global economy as the if people get reinfected every few months, this would be imminent!

> people should stick to N95/KN-95/KF-94/FFP2/FFP3 masks for the time being

Now that we have a vaccine and a bivalent booster, realize that you're suggesting masking for at least another 5 years. You said this, but it also has to be N95 at this point with how contagious it is.

> people get reinfected every few months

The realistic estimates are more like every year.

Re: Long Covid: major findings, mechanisms and recommendations

#112

Post by TechBro8615 »

dehrmann wrote: post #109
TechBro8615 wrote: post #84

Earlier quoted context omitted.

I've also not been infected that I'm aware of, although there were a couple episodes that might have been Covid. I'm tempted to pay for a blood test to check for antibodies, it only costs about $60.

Won't the vaccine trigger the production of antibodies?

It's supposed to. Not everyone's had it injected into them though.

Re: Long Covid: major findings, mechanisms and recommendations

#113

Post by l3uwin »

throw_nbvc1234 wrote: post #50
Animats wrote: post #45

This is really bad. Important points: * About 10% of people getting COVID get some form of long COVID. * There's long term damage. At least years. Maybe permanent in some cases. * You can get COVID more than once.[1] Somewhere above 6-10% of infections are re-infections, and that number increases over time. Immunity seems to last 3-18 months. What is this going to look like in 5 years? 30% - 40% of the population dis…

You're missing the variable of how severe the long covid symptoms are. If it's 10% long covid and 10% of those are serious it's only 1% of total covid cases. Unless you're using a loose definition of "disabled".

That's still millions of people

Re: Long Covid: major findings, mechanisms and recommendations

#114

Post by ETH_start »

This is a very poor analysis. Its assertion that "long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections" is based on a study that neither accounts for misattribution of symptoms to COVID, nor the psychosocial effects of a COVID infection, e.g. the anxiety related to getting COVID, the isolation required of those who contract COVID, etc.

The best evidence available suggests most cases of "long COVID" are misattribution:

https://jamanetwork.com/journals/jamainternalmedicine/fullar...

Re: Long Covid: major findings, mechanisms and recommendations

#115

Post by graeme »

nradov wrote: post #99
weaksauce wrote: post #23

Earlier quoted context omitted.

> And if unlucky, you can greatly affect the number of times you get infected through precautions. not to mention that even if you do get sick it's a continuum of sickness. you can get a little sick by getting a little bit of the virus and having an immune system that can handle that with ease. you can have the same immune system but spent too much time with your SO that got covid and was giving you a huge viral load…

There is no reliable data to support your claim of a continuum of sickness based on the inoculum dose. https://doi.org/10.1093/cid/ciab903

I’m not sure the study’s conclusion follows from its data. We lack data on humans because we can’t study infectious dose directly. But they cite multiple animals studies with worse symptoms following higher doses

I didn’t spot this notable macaque study in their review, which found fever occurred only at higher infectious doses

https://journals.plos.org/plospathogens/article?id=10.1371/j...

Re: Long Covid: major findings, mechanisms and recommendations

#116

Post by jandrewrogers »

Animats wrote: post #45

This is really bad. Important points: * About 10% of people getting COVID get some form of long COVID. * There's long term damage. At least years. Maybe permanent in some cases. * You can get COVID more than once.[1] Somewhere above 6-10% of infections are re-infections, and that number increases over time. Immunity seems to last 3-18 months. What is this going to look like in 5 years? 30% - 40% of the population dis…

I’ve had COVID multiple times — I collect variants like Pokémon cards. The first one (pre-vaccine!) was nasty with a few lingering effects that went away after a month, the last was asymptomatic. In everyone I know that has had multiple infections — which is a lot of people these days — subsequent infections are much less consequential than the last, including lingering effects. This is what you would generally expect.

It doesn’t follow that reinfection means everyone is going to get disabling long COVID eventually, especially if they weren’t susceptible the first couple times around. At least part of the reason most people don’t care about COVID much anymore is that (1) almost everyone has had it at this point and (2) if you survived the first one, there is ample empirical evidence that subsequent infections don’t have the same potential consequences so there is much less to worry about. This appears to be priced into most peoples’ view of COVID policy these days.

Re: Long Covid: major findings, mechanisms and recommendations

#117

Post by graeme »

threadweaver34 wrote: post #111
nikolay wrote: post #107

COVID-19 is no joke. I know people want to move on with their lives, but people should stick to N95/KN-95/KF-94/FFP2/FFP3 masks for the time being unless we want to create a massive health care crisis and ruin the global economy as the if people get reinfected every few months, this would be imminent!

> people should stick to N95/KN-95/KF-94/FFP2/FFP3 masks for the time being Now that we have a vaccine and a bivalent booster, realize that you're suggesting masking for at least another 5 years. You said this, but it also has to be N95 at this point with how contagious it is. > people get reinfected every few months The realistic estimates are more like every year.

I use an N95 myself, but have family who just use surgical but don’t hang out with sick people and get cautious in places with lots of people and they never got it

It’s very very contagious and you have higher odds with worse measures but it also isn’t magic.

Re: Long Covid: major findings, mechanisms and recommendations

#118

Post by jbritton »

kuhewa wrote: post #94
alchemist1e9 wrote: post #91

Earlier quoted context omitted.

https://jackanapes.substack.com/p/cdc-finally-released-its-v... It’s more amazing how due to cognitive dissonance people deny something obvious.

If an interpretation of self reported raw monitoring data seems obvious to you and your favourite criminal justice lecturer on substack, but not to epidemiologists working in the field, well yeah probably just cognitive dissonance on their part. > The CDC analysis shows that the number of serious adverse events reported in less than two years for mRNA COVID-19 vaccines is 5.5 times larger than all serious reports for…

There is a section in there “RESPONDING TO OBJECTIONS” to VAERS data. The CDC is not looking at absolute numbers.

Re: Long Covid: major findings, mechanisms and recommendations

#119

Post by kuhewa »

jbritton wrote: post #118
kuhewa wrote: post #94

Earlier quoted context omitted.

If an interpretation of self reported raw monitoring data seems obvious to you and your favourite criminal justice lecturer on substack, but not to epidemiologists working in the field, well yeah probably just cognitive dissonance on their part. > The CDC analysis shows that the number of serious adverse events reported in less than two years for mRNA COVID-19 vaccines is 5.5 times larger than all serious reports for…

There is a section in there “RESPONDING TO OBJECTIONS” to VAERS data. The CDC is not looking at absolute numbers.

For good reasons, which is why it is a peculiar choice of highlight for the criminal justice lecturer's substack article. You haven't supported your prior claim by linking it.

Re: Long Covid: major findings, mechanisms and recommendations

#120

Post by nikolay »

graeme wrote: post #117
threadweaver34 wrote: post #111

Earlier quoted context omitted.

> people should stick to N95/KN-95/KF-94/FFP2/FFP3 masks for the time being Now that we have a vaccine and a bivalent booster, realize that you're suggesting masking for at least another 5 years. You said this, but it also has to be N95 at this point with how contagious it is. > people get reinfected every few months The realistic estimates are more like every year.

I use an N95 myself, but have family who just use surgical but don’t hang out with sick people and get cautious in places with lots of people and they never got it It’s very very contagious and you have higher odds with worse measures but it also isn’t magic.

How do you know who's sick when 30-40% of people are asymptomatic? Also, the virus lingers in the air of closed spaces of hours.
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