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Long Covid: major findings, mechanisms and recommendations

nature.com

91–100 of 229 posts

Re: Long Covid: major findings, mechanisms and recommendations

#91
post #90

Earlier quoted context omitted.

[flagged]

> Repeated vaccination is likely not going to be a scientifically justified strategy. It is kinda of amazing to me sometimes just how selectively people can parse an evidencebase

https://jackanapes.substack.com/p/cdc-finally-released-its-v...

It’s more amazing how due to cognitive dissonance people deny something obvious.

Re: Long Covid: major findings, mechanisms and recommendations

#92

Earlier quoted context omitted.

Significantly worse than the flu - multi systemic organ damage. The narrative that covid is like the flu, is both wildly inaccurate as this paper explains, and also dangerous, leading to a more cavalier attitude towards covid prevention.

Maybe I'm being generous to the parent, but I also would like a comparison to the flu. Not because I don't believe covid is significantly worse (when I got it, it was way worse than the flu), but because I don't have a medical background and it is difficult to contextualize the actual risks here without some baseline where I have a decent intuition already built around. But where I disagree with the parent is the nee…

But have you actually had the flu? I ask, because most people say “oh, I had the flu” when in actuality they just had a common cold.

The flu, the real flu, knocks you on the ass so hard that you actively start considering that death is a possibility and that heading over to the hospital would be a good idea.

I’ve had the flu perhaps twice. Once as a child, once in my early 50s. The latter completely recalibrated my understanding of illness.

Re: Long Covid: major findings, mechanisms and recommendations

#93
post #7

Fascinating read. I'm glad to see these findings get serious attention by researchers. It was really frustrating getting dismissed by my local physician when sharing symptoms like sugar sensitivity, fatigue, and focus issues. It was like being perpetually tipsy for months. It was a big shock as a knowledge worker to have to relearn how focus. I hope they further study vaccines as well. In my anecdotal case my long co…

>In my anecdotal case my long covid symptoms resumed, along with additional symptoms like body bruising / bone pain for several weeks.

The term used in Germany for "long-covid like symptoms after vaccination" is "post-vac syndrome". Having seen something similar in English yet.

Re: Long Covid: major findings, mechanisms and recommendations

#94
post #90

Earlier quoted context omitted.

> Repeated vaccination is likely not going to be a scientifically justified strategy. It is kinda of amazing to me sometimes just how selectively people can parse an evidencebase

https://jackanapes.substack.com/p/cdc-finally-released-its-v... It’s more amazing how due to cognitive dissonance people deny something obvious.

If an interpretation of self reported raw monitoring data seems obvious to you and your favourite criminal justice lecturer on substack, but not to epidemiologists working in the field, well yeah probably just cognitive dissonance on their part.

> The CDC analysis shows that the number of serious adverse events reported in less than two years for mRNA COVID-19 vaccines is 5.5 times larger than all serious reports for vaccines given to adults in the US since 2009 (~73,000 vs. ~13,000).

Wait, the self report monitoring system that went from virtually unknown to a household name at a time the number of adult vax administrations skyrocketed.. detected an uptick in absolute number of adverse events? Stop traffic! This article is off to a great start.

Re: Long Covid: major findings, mechanisms and recommendations

#95
post #90

Earlier quoted context omitted.

> Repeated vaccination is likely not going to be a scientifically justified strategy. It is kinda of amazing to me sometimes just how selectively people can parse an evidencebase

https://jackanapes.substack.com/p/cdc-finally-released-its-v... It’s more amazing how due to cognitive dissonance people deny something obvious.

[flagged]

Re: Long Covid: major findings, mechanisms and recommendations

#96
post #74

This has basically nailed the stuff my wife developed “out of nowhere” toward the end of 2021. Wow. I wonder how one convinces doctors to take that seriously? It’s been a real nightmare.

My wife started to have many of the symptoms of long COVID starting around September of this year. No official diagnosis from her many doctors and specialists, just a constant barrage of co-pays and test after test after test. Some of her doctors say for certain it is not long COVID but they also say they do not know what it is... so... uh huh. Just have to keep on testing, and do the same test multiple times.

There isn’t really a diagnostic test for long covid. There’s been some interesting research and anecdotes around microclots and oxygen flow.

https://xdrx.substack.com/p/how-i-recovered-from-long-covid-...

Re: Long Covid: major findings, mechanisms and recommendations

#97

Earlier quoted context omitted.

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.0...

> new research is uncovering serious and significant risks for the vaccine The frequency of the reaction mentioned in this article is around 2 in 100,000 people. The frequency of death from covid is somewhere in the range of 1000-2000 in 100,000 people. I'll take the vaccine odds. > with fairly marginal protection benefits Your source says nothing about protection benefits being marginal. In fact, one of the author's…

As individuals those averages are looking at too large of a group. There are known subgroups with different risk profiles and grouping them together isnt helpful. You get very different risks from both for for example a healthy 60yo male.

We have had that data for a while and simplifications serve no benefit. Its not early 2020 anymore, as always, as we get more accurate data, we get to adapt some strategies based on that.

edit: Not to mention the difference in strains (omicron vs delta) as well as the confidence into the different risks (under counting (detection problem) vs over counting(hospitalized/dying from vs with covid)

Re: Long Covid: major findings, mechanisms and recommendations

#98
post #8

Earlier quoted context omitted.

> Can anyone more medically and scientifically literate provide some context to temper my doom and gloom? Most of these issues stem back to endothelium damage. And the good news is that, in addition to taking all the vaccines you're eligible to get, there are a bunch of other things you can do to strengthen and protect your endothelium, e.g. doing HIIT and taking ACE inhibitors. The one risk we (afaik) don't really k…

Except for me and many others long covid symptoms got worse after vaccination. Additionally new research is uncovering serious and significant risks for the vaccine with fairly marginal protection benefits.

I assume this is collecting some downvotes because it's unclear if the second sentence is supposed to apply specifically to the long covid population or the general population.

Based on the submitted paper, if it is intended to apply specifically to the long covid population, then it seems to be a reasonable comment. It did mention post-long-covid vaccinations seemed to be more harmful than helpful - something like ~15% found their long covid symptoms improved afterwards while ~20% had their symptoms worsen.

If that second sentence was intended to apply to the general population, then it's neither supported nor contradicted by the submitted paper. I don't believe it addressed risks outside of those already suffering from long covid. While it did address protection against long covid, it didn't come to a particular conclusion on the matter. It mentioned that studies on this aren't in general agreement yet, and pointed out a number of potential reasons for this, such as varying and potentially incomplete standards for discriminating between both long covid and control groups, in addition to the basic difficulties involved in keeping up with new strains.

As for other research... well that's a whole other thing.

Re: Long Covid: major findings, mechanisms and recommendations

#99
post #15

Earlier quoted context omitted.

> As far as I can tell, everyone is going to get COVID This is a common feeling, but remember: You can greatly affect the probability of an infection through precautions. And if unlucky, you can greatly affect the number of times you get infected through precautions. Fewer infections, fewer rolls of the dice. As far as I'm aware, I'm still infection free and hope to remain so. I am in a much better situation than mos…

> And if unlucky, you can greatly affect the number of times you get infected through precautions. not to mention that even if you do get sick it's a continuum of sickness. you can get a little sick by getting a little bit of the virus and having an immune system that can handle that with ease. you can have the same immune system but spent too much time with your SO that got covid and was giving you a huge viral load…

There is no reliable data to support your claim of a continuum of sickness based on the inoculum dose.

https://doi.org/10.1093/cid/ciab903

Re: Long Covid: major findings, mechanisms and recommendations

#100
post #56
post #41

Earlier quoted context omitted.

What are liver supper supplements? Is there any research on this?

I found popular ones on Amazon. I tried it because of doing research on my high numbers for Epstein-Barr (aka mono). I found via NIH papers that liver issues are common with mono patients so I figured I could be having that since there were no other obvious blood results. I had Covid beforehand and when I had extreme fatigue I had the mono tests done. The EBV numbers were off the charts and then I found some NIH pape…

It's funny you mention that—I had Mono over a decade ago and it was a long ordeal for me. Multiple weeks of fatigue and feeling like crap. Mono was way worse than Covid in my instance—but they felt very similar.
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