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Long Covid: major findings, mechanisms and recommendations

nature.com

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Re: Long Covid: major findings, mechanisms and recommendations

#21

Post by godelski »

squidsoup wrote: post #12
roenxi wrote: post #5

As always, it is difficult to assess this sort of thing without a reference to the flu. As far as I can tell, in daily life we are continuously encountering people with various chronic problems and systemically under-calling the impact of them. It is a total coincidence if a body is functioning at full capacity. If COVID increases the hazard ratios there isn't much I can do. As far as I can tell, everyone is going to…

Significantly worse than the flu - multi systemic organ damage. The narrative that covid is like the flu, is both wildly inaccurate as this paper explains, and also dangerous, leading to a more cavalier attitude towards covid prevention.

Maybe I'm being generous to the parent, but I also would like a comparison to the flu. Not because I don't believe covid is significantly worse (when I got it, it was way worse than the flu), but because I don't have a medical background and it is difficult to contextualize the actual risks here without some baseline where I have a decent intuition already built around. But where I disagree with the parent is the need for this paper to specify those distinctions as I'm not the target audience.

I can read data and understand it, but any good data scientist knows that you need real expertise in a domain to contextualize that data. It would be naive to think that my understanding of data directly translates to a strong understanding of this work. I'm not the domain expert.

Re: Long Covid: major findings, mechanisms and recommendations

#22

Post by alchemist1e9 »

Alex3917 wrote: post #8
soderfoo wrote: post #4

Unease and woe are the two feelings I'm left with after my quick layman reading of the article. Think I am most concerned with the reproductive implications, which seem under researched. Coupled with the unrelated decline in sperm count the past decade... I'm hoping my ruminations are just me catastrophizing. Can anyone more medically and scientifically literate provide some context to temper my doom and gloom?

> Can anyone more medically and scientifically literate provide some context to temper my doom and gloom? Most of these issues stem back to endothelium damage. And the good news is that, in addition to taking all the vaccines you're eligible to get, there are a bunch of other things you can do to strengthen and protect your endothelium, e.g. doing HIIT and taking ACE inhibitors. The one risk we (afaik) don't really k…

Except for me and many others long covid symptoms got worse after vaccination. Additionally new research is uncovering serious and significant risks for the vaccine with fairly marginal protection benefits.

Re: Long Covid: major findings, mechanisms and recommendations

#23

Post by weaksauce »

stubish wrote: post #15
roenxi wrote: post #5

As always, it is difficult to assess this sort of thing without a reference to the flu. As far as I can tell, in daily life we are continuously encountering people with various chronic problems and systemically under-calling the impact of them. It is a total coincidence if a body is functioning at full capacity. If COVID increases the hazard ratios there isn't much I can do. As far as I can tell, everyone is going to…

> As far as I can tell, everyone is going to get COVID This is a common feeling, but remember: You can greatly affect the probability of an infection through precautions. And if unlucky, you can greatly affect the number of times you get infected through precautions. Fewer infections, fewer rolls of the dice. As far as I'm aware, I'm still infection free and hope to remain so. I am in a much better situation than mos…

> And if unlucky, you can greatly affect the number of times you get infected through precautions.

not to mention that even if you do get sick it's a continuum of sickness. you can get a little sick by getting a little bit of the virus and having an immune system that can handle that with ease. you can have the same immune system but spent too much time with your SO that got covid and was giving you a huge viral load of it that your immune system couldn't handle. masking up when out using an n95 is a layer that lets a little bit in if you are around someone sick.

people seem to think "oh it's a crapshoot if i get bad covid or not" no it's a confluence of reasons that you could get sicker than you would have otherwise. masking, off hours shopping, delivery, working from home, not going to really crowded places. that's all stuff you can do even if you don't plan on getting updated vaccines which you should.

Re: Long Covid: major findings, mechanisms and recommendations

#24

Post by _kulang »

thewizardofaus wrote: post #10

Covid fatigue is no joke. As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep. I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal". The most frustrating thing is…

Similar experience — and interestingly it can be seen in my resting heart rate over time and VO2 inference on my watch. The acute fatigue was quite bad (and is what people seem to talk about) but the milder lingering fatigue reduced my running and lifting performance across the board and left me tired in the late afternoon rather than the evening. It’s not life altering per se, but it impacted my routines and productivity noticeably.

Thankfully after 5 months I seem to have kicked it fully, and am ripe for another infection. Needless to say I got the bivalent booster before the holidays

Re: Long Covid: major findings, mechanisms and recommendations

#25

Post by twawaaay »

thewizardofaus wrote: post #10

Covid fatigue is no joke. As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep. I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal". The most frustrating thing is…

I feel for you. This is such a strange virus.

My whole family got covid so I expected to be next. But I only needed to take 2 days off at work and I paused my training for just 3 days and was almost back to my normal HR/pace in less than a week since I got first symptoms. It took me 3 more weeks before I started getting negative test results.

Re: Long Covid: major findings, mechanisms and recommendations

#26

Post by RandomWorker »

thewizardofaus wrote: post #10

Covid fatigue is no joke. As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep. I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal". The most frustrating thing is…

That sucks. My experience was to get back to training fairly soon (2 weeks after fever went away). After that training session I knew I should rest more and took an additional 2 weeks off. Then built back up my regular training starting at 10% volume and increasing at 10% increases each week. After 3 months I was back to regular volume. My suggestion is that everyone take at least two weeks off, and build up volume very conservatively. I’ve had lots of conversations with other people that love to train. It’s hard to take it easy and do less because we love training, but this protocol seems to work for many. Maybe it’s too conservative and everyone is different.

Re: Long Covid: major findings, mechanisms and recommendations

#27

Post by dontknowwhyihn »

alchemist1e9 wrote: post #22
Alex3917 wrote: post #8

Earlier quoted context omitted.

> Can anyone more medically and scientifically literate provide some context to temper my doom and gloom? Most of these issues stem back to endothelium damage. And the good news is that, in addition to taking all the vaccines you're eligible to get, there are a bunch of other things you can do to strengthen and protect your endothelium, e.g. doing HIIT and taking ACE inhibitors. The one risk we (afaik) don't really k…

Except for me and many others long covid symptoms got worse after vaccination. Additionally new research is uncovering serious and significant risks for the vaccine with fairly marginal protection benefits.

[flagged]

Re: Long Covid: major findings, mechanisms and recommendations

#28

Post by eismcc »

thewizardofaus wrote: post #10

Covid fatigue is no joke. As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep. I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal". The most frustrating thing is…

Similar situation. Did a 70.3 in June and then was laid out flat like I had never been before. My watch was telling me numbers that looked like I did a full Ironman every day. For months.

I found that liver support supplements made a measurable impact.

Re: Long Covid: major findings, mechanisms and recommendations

#29

Post by lotsofpulp »

squidsoup wrote: post #12
roenxi wrote: post #5

As always, it is difficult to assess this sort of thing without a reference to the flu. As far as I can tell, in daily life we are continuously encountering people with various chronic problems and systemically under-calling the impact of them. It is a total coincidence if a body is functioning at full capacity. If COVID increases the hazard ratios there isn't much I can do. As far as I can tell, everyone is going to…

Significantly worse than the flu - multi systemic organ damage. The narrative that covid is like the flu, is both wildly inaccurate as this paper explains, and also dangerous, leading to a more cavalier attitude towards covid prevention.

I have had Covid at least 2 times and influenza once in the last 2 or 3 years. The influenza is the one that knocked me on my ass and sent me to the doctor thinking I might have something more wrong with me. Covid was meh, not worse than any other sickness the toddlers bring home.

Re: Long Covid: major findings, mechanisms and recommendations

#30

Post by TurkishPoptart »

thewizardofaus wrote: post #10

Covid fatigue is no joke. As an Elite Athlete I'm training 20-30 hours a week. I got covid last year (triple vaxed) and it wiped me out for a good 6 months. It took me 3 weeks to be able to walk longer than a minute without needing to lay down for the rest of the day and sleep. I have dealt with fatigue problems for 6 months and only just now, do I feel like I'm getting "back to normal". The most frustrating thing is…

[flagged]
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