I too suffered from wrist pain and fatigue in the past. The experimentation with different layouts helped a little but it felt like micro-optimization. What actually resolved the problem was switching to an unorthodox ergonomic keyboard where none of the keys required straining or unnecessary effort (kinesis advantage, using a different one these days). Also, most common problems were caused by placement of special k…
What helped we is switch from C++ to Ruby. I see analogy to guitar player here too. And Dvorak of course. I can use it on notebook.
This is a great point. Some languages have terrible ergonomics - those which rely heavily on brackets which are poorly placed on a keyboard. Ergodox layouts tend to map brackets to the second layer on ER,DF,CV keys to mitigate this. But it's better for languages to not require braces at all.