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GLP-1 drugs linked to lower death rates in colon cancer patients

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#111

Post by 01100011 »

rootusrootus wrote: post #85
cerved wrote: post #34

Earlier quoted context omitted.

Well glp1 doesn't make you want to eat broccoli. Just less in general

Actually there is a very real effect on which foods you find appealing and which ones are kind of gross. It’s a thing the food companies have been studying, and their own studies show that people on GLP1s tend to skip the junk food aisle and head towards the produce section instead.

Oddly enough semaglutide is making me crave sugar more. It might be the frequent sensation of having low blood sugar. Idk.

It does make me choose more dense meals though since I know I can't eat that much due to delayed gastric emptying. But I have to budget some room for prunes to counteract the constipation. It definitely makes you think about what you eat.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#112

Post by hexbin010 »

surfsvammel wrote: post #59

I am on GLP-1 (very low dose), and I’ve found that it seems to help me moderate my alcohol consumption as well. Maybe some thing like that could also be contributing to the effect.

Same here. There's less wanting it but also, if I do indulge even one small glass of wine, the side effects are awful: broken sleep, acid reflux and a hangover the next day. It really slaps you in the face for indulging

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#113

Post by l5870uoo9y »

cyrusradfar wrote: post #81
jl6 wrote: post #22

> However, the study authors emphasize that more research is needed to confirm these mechanisms and determine whether the survival benefit observed in this real-world analysis represents a direct anti-cancer effect or an indirect result of improved metabolic health Given it’s an observational study, I would bet on the latter. It’s really hard to know you’ve controlled for all confounding factors, and there’s a strong…

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

There is no such thing as water fasting. I would characterize it as an eating disorder.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#114

Post by WillPostForFood »

cess11 wrote: post #103
exabrial wrote: post #80

Earlier quoted context omitted.

This is a great example of a straw-man attack.

No, it is not. They said that since someone, which is typically a fictive person, had spent a lot of money, they deserve to restrict physical persons' access to supposedly life saving substances. I would like to know how far they take that position.

How many people do you feel liek you are personally responsible for killing because you haven't given 100% of your disposal income to food relief? Hundreds? Thousands?

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#115

Post by _cenw »

itchyouch wrote: post #95
cyrusradfar wrote: post #81

Earlier quoted context omitted.

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

An interesting FYI is a comment made by Peter Attia on his podcast. He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss. They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects. It seems like GLP1, even in skinny patients (…

(Outer) Thigh, upper arms and stomach are the on-label injection sites for these drugs.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#116

Post by _cenw »

robbomacrae wrote: post #4
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

There have been some. I've heard about eyesight related issues. A quick google found this article [0] where results showed that people using GLP-1 drugs were 68.6 times more likely to develop certain types of vision problems. [0]: https://www.aao.org/newsroom/news-releases/detail/do-glp-1-d...

A large drop in HbA1c does cause early worsening of diabetic retinopathy. Regardless of how it's achieved. So expect some noise in generalized data.

Personally, I went from mild background retinopathy to PDR and getting laser treatment in about 3 months. My ophthalmologist (who has an academic background) didn't really know if this diagnosis had the same "quality" of someone who "naturally" progresses to PDR, but some studies say it's transient.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#117

Post by CobrastanJorji »

richwater wrote: post #67
surfsvammel wrote: post #59

I am on GLP-1 (very low dose), and I’ve found that it seems to help me moderate my alcohol consumption as well. Maybe some thing like that could also be contributing to the effect.

Is there evidence for addiction tendencies in general? Or is it something specific to alcohol?

From my friends on GLP-1s, I'm pretty sure that it's mostly that it makes you really sick fairly quickly when you drink even in moderation.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#118

Post by cyrusradfar »

amenhotep wrote: post #106
trallnag wrote: post #94

Earlier quoted context omitted.

Awesome insight. It's not the disability I have, it's that I have never tried healing by fasting. Of course. Because my body was always busy trying to eat food instead of fixing and regrowing all the malformed tissue. Because that's how it works. When a person without legs starts to fast, the legs will suddenly develop.

It would be sensible for you to examine and interrogate why reading a general and fairly anodyne opinion about what might be a solution to a problem some people have led you to interpret it as a prescriptive and judgemental suggestion about the specific problem you specifically have.

Appreciate the thoughtful retort. Have a good one.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#119

Post by ashdksnndck »

cess11 wrote: post #64
exabrial wrote: post #21

Earlier quoted context omitted.

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

Kind of weird to assume other people think it's fine to exchange human lives for money. Is it ethical for me to pay someone to murder you? Does it matter if it costs me a large amount of money or not?

Why do we pay doctors? Are they evil if they refuse to go to work for free?

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#120

Post by cyrusradfar »

l5870uoo9y wrote: post #113
cyrusradfar wrote: post #81

Earlier quoted context omitted.

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

There is no such thing as water fasting. I would characterize it as an eating disorder.

Umm.

Sources?

  - https://en.wikipedia.org/wiki/Fasting
  - https://zerolongevity.com/blog/the-history-of-fasting/
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