Live data from Hacker News

A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

nature.com

111–120 of 162 posts

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#111
post #50

Earlier quoted context omitted.

> It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now, while the food I used to eat honestly don't appeal to me any longer or tastes empty. Having tried this, by basically eating a lot of carrots, its uh, not the same as being full/satiated. Feeling like your stomach is full is just a completely different feeling f…

I wonder if the satiated feeling isn't from volume but from some nutrient showing up in blood or in intestinal detectors for something signaled as in short supply.

I think the satiated feeling is from your body having enough fat. Rich, heavy meals will trigger it.

Carbs cause the opposite, they trigger the need to eat more (carbs).

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#112
post #58

Earlier quoted context omitted.

A calorie measures the heat released by setting the food on fire, which is not how your body metabolizes food. It's a proxy. You should be measuring the ATP yielded by eating food. For example, a molecule of glucose yields 32 ATP when metabolized, yet a molecule of DHA yields 136 molecules of ATP - nearly twice as many as predicted by the "calories" proxy. However, in the absence of oxaloacetic acid (as when the live…

> You should be measuring the ATP yielded by eating food. The closest practical approximation of this is the calorie measurement we assign to foods. Sure our metabolic processes are not equivalent to a calorimeter - but its easier to measure calories than to account for the specific metabolic process each gram of macronutrient you consume goes through. So for all practical purposes, and in the context of hormonal eff…

You clearly didn't read the rest of my comment.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#113
post #105
post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Gym bro science gets a bad rap here for whatever reason, but I’d bet dollars to donuts that you’re better off following a 1970s bodybuilder diet (scaled appropriately) than whatever the latest garbage the FDA and USDA are pushing. Sure plenty of it is nonsense, like eating 6 meals a day, but it’s mostly harmless nonsense. That’s in stark contrast to the food pyramid recommendation to eat a couple loafs of bread each…

People hate on the dietary guidelines a lot but adherence is only 50-60% in the US.

A slight overconsumption of grains, large overconsumption of meat, and massive under consumption of vegetables and fruits and dairy.

I looked this up recently. On my phone but googling “adherence of us population to dietary guidelines” may help.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#114
post #50

Earlier quoted context omitted.

> It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now, while the food I used to eat honestly don't appeal to me any longer or tastes empty. Having tried this, by basically eating a lot of carrots, its uh, not the same as being full/satiated. Feeling like your stomach is full is just a completely different feeling f…

not to get down in the weeds but carrots aren't that fibrous, but their *available fiber content goes up 2.5x when you cook them, from about 2g per stick to 5g. leafy greens, especially kale, are better for filling up. and you still need protein and fat on top of that.

I will try this.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#115

Earlier quoted context omitted.

Advice from a T2 Diabetic and regular Keto dieter. If you have never given up sugar before, it will take at least 6-8 weeks of non-use before the cravings go away. These will be some of the hardest weeks too. 1) everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most p…

> everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most processed and store bought foods. Realistically how do you avoid sugar like this? Soft drinks, candy, and other artificial stuff are easy enough to avoid, but most bread? Fruits? What are you supposed to eat and…

An easy way to get most of the way there:

- Minimal to no fruit (that includes tomato).

- Don't eat anything that comes in a package or that has an ingredients list more than 1 item long (so, frozen broccoli is fine, as long as there's no extra stuff in the bag).

- Don't eat anything that your great grandparents wouldn't have had access to.

Some things, like bell peppers, will start tasting like candy after a few weeks of this.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#116
post #63

Earlier quoted context omitted.

For increased satiety, even when eating little, an additional factor is that the food should not be too soft, like most of the industrially made food is, but it should need some time of vigorous chewing. There are many vegetables, fruits and nuts that require a decent amount of chewing. There are also some kinds of home-made bread that require much more chewing than the industrial soft bread, while also being much ta…

Got any chewey bread recipes?

Another poster has already given a good recipe.

Besides such more elaborate recipes, after a little experimentation it is also possible to make bread with simplified recipes and preparation.

For example, in most days I make a bread to be eaten at breakfast, which needs less than 20 minutes for making, distributed over a duration of less than an hour.

It is baked in a microwave oven, which takes much less time than in a conventional oven and which is perfectly reproducible (the time depends on the microwave oven and on the amount of dough, so it must be found by experiments; in my oven @ 1000 W I use 13 minutes for dough made of 500 g of wheat flour, in a glass vessel covered by a lid).

Sometimes I add various spices, but even pure bread made only of wheat flour and water can be very good. I make the dough from wheat floor (with 12% proteins) + water having 75% of the mass of the floor. The dough is kneaded for a few minutes in a glass bowl, until becoming homogeneous and elastic. Then it is left 30 minutes, to become cohesive.

Then I wash for a few minutes the dough while kneading it, to remove a part of the starch, because I want to obtain a bread with high protein content, which causes more satiety than conventional bread, both due to the high protein content and by being more chewy. Then I bake it and I eat it after it cools enough. Of course, washing the dough is optional.

For softer bread, a leavening agent can be used. Nevertheless, when the dough is baked in a microwave oven, due to the internal heating, even the unleavened dough grows about 30% to 40% of what it would grow when leavened, due to the expansion of the incorporated air and water.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#117
post #82

I read a lot of good things about intermittent fasting. Is there a good canonical resource if I want to try it? Note that I am lifting weighs 3 times per week. Is IF still a good idea...? I don't feel confident that this is something that I can lift with my GP, as it is not part of their standard set of guidelines (?)

IF seems to be one of many techniques to restrict your overall calorie consumption. Each technique is suited to a different person's schedule, personality, vices etc. It's less about the chemistry happening in the body and more about the matching of diet to personality choices. As for IF while lifting? Depends on your goals.

OK! I was under the impression that it had tangible health benefits like better cardio-vascular health regardless of diet, better well-being/mood.

In other words, I assumed that IF is not just good for weight-loss or weight maintenance.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#118

Earlier quoted context omitted.

Don't drop sugar imo For all the similar reasons you gave, except - no sugar, no energy. You may wonder why a skinny af cyclist will happily consume 6k+ calories a day, as well as shovelling glucose gels down. Endurance athletes get it best: long distance cycling is just an all-day eating competition.

The analogy between salt and sugar does not really work. Sugar is not an essential nutrient. You can eat absolutely no sugar without any ill effect. If you eat some starchy vegetables, that provides all the carbohydrates you need. Even if you want to eat 6000 kcal as carbohydrates, you can eat that easily from rice/maize/bread/potatoes etc., with no sugar. In fact it is much easier to eat a huge amount of food when i…

For cycling, sugar (really a mix of glucose and fructose, which sucrose or sugar is an even mix of) is a necessary component to a fueling strategy because even a marginally fit individual will burn more in an hour than can be processed by the glucose pathway alone. The goal isn’t to meet some daily allotment, but to get as much high GI carbs into the bloodstream as your gut can take, as fast as possible. This has been linked to higher performance and reduced fatigue in the literature, not to mention this is what 100% of pros do (there are no keto pros).

One benefit of this, like you say, is you develop a general disgust for sweets and have no interest in them outside of training.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#119
post #31
post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

> What I've found is that matters is appetite: some people just get full way faster than others. This is a half truth. If you cut down portion size your stomach will shrink over time. I eat a lot less before feeling full now, and I only changed my life a year ago. It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now…

AFAIK the stomach remains the same size, but what changes is how your body processes hunger. I've noticed while fasting that after a while, my body gets used to reduced food intake. Then I can get full by eating considerably less than what I'd call a normal sized meal.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#120
post #58

Earlier quoted context omitted.

Hormones, appetite, metabolic diseases are all orthogonal to CICO. These can have an effect on how many calories you burn or how many calories you crave but at the end of the day, CICO is still law.

A calorie measures the heat released by setting the food on fire, which is not how your body metabolizes food. It's a proxy. You should be measuring the ATP yielded by eating food. For example, a molecule of glucose yields 32 ATP when metabolized, yet a molecule of DHA yields 136 molecules of ATP - nearly twice as many as predicted by the "calories" proxy. However, in the absence of oxaloacetic acid (as when the live…

What are you eating at 3500 calories a day that allows gluconeogenesis without intense exercise. From your comment this seems to indicate you are limiting carbohydrates. What does your diet consist of?
Post reply on HN