Thomas Jefferson is to blame and not one mention of taxes? I would be really surprised that some research wouldn't find that many of these office parks are built outside of the borders of major cities to avoid paying taxes, or were provided incentives by neighbouring municipalities to build further out and pay lower tax. The lower cost is attractive and allows the company to operate in a big shiny building that immed…
How does that explain that these low tax buildings are now being left empty in favor of options in the higher tax cities? If they were so desirable they wouldn't be sitting empty.
With respect to the particular building mentioned in the article, it is hardly surprising at all that the NIH is contracting its footprint given recent funding history.
Edit: As mentioned by another commenter, it turns out the NIH didn't move things downtown. Instead, it's just opened a brand new campus that's even further away.