Earlier quoted context omitted.
Forget physical pain. Opiates make the mental pain, the pain of existence go away. Stress, business problems, finances, it's all manageable with opiates. Most people don't know just how much better human existence can be with a bit of tweaking to our chemistry. We accept we're no longer in our ancestral environment, why can't we accept that our default chemistry is suboptimal?
Suboptimal in what way? We create, develop, improve because we are unsatisfied, not because we are happy.
The pain of wanting is a very powerful pain. This is why the road to enlightenment requires you to give up your want.