Earlier quoted context omitted.
Your equation is correct in a Newtonian universe, but does not consider relativistic effects. Generally when we talk about an object's acceleration, we are talking about its acceleration in its own reference frame. By definition, an object's velocity in its own reference frame is always 0, so acceleration does not become more difficult (ignoring the fact that the surrounding matter will be impacting you at higher spe…
So why is it difficult to maintain a constant acceleration? Is 1g really that impractical right now?
Jokes aside, there's no fuel source we know of that would allow a ship to accelerate continuously for 50 years at 1g.