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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

nature.com

21–30 of 88 posts

Re: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

#21
post #7

Am I the only one who finds this caloric restriction stuff depressing? If starving for 50 years will increase my life I don't even want to know about it. Stupid science. Next they're going to tell us that a combination of caloric restriction & celibacy will do even more.

Well, orgasm results in a surge of prolactin which is known to have certain negative effects. There's arguably a case for keeping orgasm frequency low.

Re: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

#22
post #6

So if you don't eat much you may live longer. It will certainly FEEL longer.

While stated as sarcasm, this is a very reasonable concern. Suppose we can extend human life with Calore Restriction, but at the cost of having to slow person's activity to the point that the overall amout of actions (work, leisure etc.) remains the same as during shorter, more intense life. Would that still be worth it? What would a person gain through longer lifespan if she was limited to roughly the same amout of…

Just thinking all futurism here, but it could be useful in the case where we don't need as much physical activity but rely more on thinking, or if we have things pretty automated and just need to wait for things that take a long time.

Re: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

#24

The test is lab grade monkey chow vs. less lab grade monkey chow. I don't think one can extrapolate that eating less calories on a very high quality and low toxin source of calories is better. Monkeys do best on perfectly ripe and fresh tropical fruits. Is that what they were eating? I really doubt it.

To be fair, monkeys eating a bunch of processed lab grade crap is probably a better approximation for the modern human than an optimal diet.

Re: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

#26
post #7

Am I the only one who finds this caloric restriction stuff depressing? If starving for 50 years will increase my life I don't even want to know about it. Stupid science. Next they're going to tell us that a combination of caloric restriction & celibacy will do even more.

Ageing has been such an insurmountable problem, any methods that indicate that there are ways to somewhat control it are promising and can lead to other discoveries.

Perhaps CR only invokes the release of hormones that have a protective effect on cells. Replicate the hormone and perhaps actual caloric restriction may not be necessary.

Re: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

#27
post #17

Earlier quoted context omitted.

I kind of agree, quality of live is important as well

If you could live forever on the condition that you did not eat, would you say no?

> If you could live forever on the condition that you did not eat, would you say no?

It entirely depends on how that condition materialized. Would I be hungry forever (but somehow live)? Then no.

If I would never be hungry, then that sounds wonderful.

Re: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

#28
post #6

So if you don't eat much you may live longer. It will certainly FEEL longer.

While stated as sarcasm, this is a very reasonable concern. Suppose we can extend human life with Calore Restriction, but at the cost of having to slow person's activity to the point that the overall amout of actions (work, leisure etc.) remains the same as during shorter, more intense life. Would that still be worth it? What would a person gain through longer lifespan if she was limited to roughly the same amout of…

Why speculate when we already have some data on activity levels under CR?

http://en.wikipedia.org/wiki/Calorie_restriction#Activity_le...

Re: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

#29
post #26
post #7

Am I the only one who finds this caloric restriction stuff depressing? If starving for 50 years will increase my life I don't even want to know about it. Stupid science. Next they're going to tell us that a combination of caloric restriction & celibacy will do even more.

Ageing has been such an insurmountable problem, any methods that indicate that there are ways to somewhat control it are promising and can lead to other discoveries. Perhaps CR only invokes the release of hormones that have a protective effect on cells. Replicate the hormone and perhaps actual caloric restriction may not be necessary.

OK crusso. I like the way you think.

From now on you are now in charge of all budgets, articles, blogs, tweets and laboratories relating to CR research. May I suggest that your first fiat be that CR will henceforth only be referred to by acronym.

Re: Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

#30

I thought about doing CR for a while - I read the "120 Year Diet," and was considering giving it a try. Then I met up with a couple who was into hardcore CR. I had dinner with them. Two things made me decide not to do it: 1) they seemed frail and weak - the man seemed to have a constant runny nose. I felt that if he fell down he would break his hip. The risk of injury and death from physical weakness seemed like it w…

Ketogenic diet combined with intermittent fasting can be simple solution for this. Ketogenic diet controls your appetite and having one meal a day helps you to control your calorie intake.
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