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Anti-ageing compound set for human trials after turning clock back for mice

theguardian.com

181–190 of 243 posts

Re: Anti-ageing compound set for human trials after turning clock back for mice

#181
post #142
post #101

Hmm... As I'm new here I'm a little confused. I posted the same article yesterday but this one posted by Mizza got picked up quite heavily. Does the poster's "karma" have something to do with it? Or is it just a coincidence?

Sundays typically are more accepting of this kind of content. I also posted a link to the article in Cell as a comment with the submission. shrug It's really just timing though.

;) Thanks for the response.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#182
post #64
post #52

Earlier quoted context omitted.

This post fills me with questions. Foremost: What makes anti-aging technology unnatural compared to other medical treatments? To take one example, the smallpox vaccine was initially considered unnatural, and an affront to God[1]. [1] http://abob.libs.uga.edu/bobk/whitem10.html

I think it's fair to call most medical treatments unnatural. That doesn't make them bad, but it should make us thoughtful and careful. Natural systems are often, thanks to evolution and adaptation, complicated and delicately balanced. I think reflexive appeals to tradition and novelty are both kind of dumb. But if people are going to err, I'd rather they erred on the side of tradition: at least that shit has been dem…

[deleted]

Re: Anti-ageing compound set for human trials after turning clock back for mice

#183
post #25

Earlier quoted context omitted.

Well I do see this quote: "Turner said a “magic pill” that reverses ageing is several years away, partially due to the cost of the compound, which would be about $50,000 a day for a human." So in guessing there's some special processing of the compound or a special way to get it into each cell somehow.

Currently, you can buy NADH, which seem different, or NAD+ precursors (Niacin, Niacinamide) or Niagen ( https://chromadex.com/Ingredients/NIAGEN.html ), which is proprietary and suppoedly increasing NAD+ levels. It's pretty expensive as of now compared to Niacin, but, still, $50/month isn't that much. Combining Niagen with Resveratrol should do the trick.

I've been taking Niacinamide + Resveratrol for over 2 years. Honestly, I don't see any positive effect, but neither I see any negative effects either. Given I'm 40 now, I'm not 100% sure if this is a negative or a positive outcome. For example, without any supplementation, maybe I should've aged more... but how can I know for sure. My point it, as long as the supplement is orthomolecular, the negative side of spending a few dollars per month is well-justified.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#184
post #177
post #25

Earlier quoted context omitted.

Currently, you can buy NADH, which seem different, or NAD+ precursors (Niacin, Niacinamide) or Niagen ( https://chromadex.com/Ingredients/NIAGEN.html ), which is proprietary and suppoedly increasing NAD+ levels. It's pretty expensive as of now compared to Niacin, but, still, $50/month isn't that much. Combining Niagen with Resveratrol should do the trick.

Any expected or potential side effects?

I've been taking Niacinamide + Resveratrol for over 2 years. Honestly, I don't see any positive effect, but neither I see any negative effects either. Given I'm 40 now, I'm not 100% sure if this is a negative or a positive outcome. For example, without any supplementation, maybe I should've aged more... but how can I know for sure. My point it, as long as the supplement is orthomolecular, the negative side of spending a few dollars per month is well-justified.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#185

Earlier quoted context omitted.

More accurately, professional philosophers don't have any particular standing to discuss "serious philosophical issues." At any point in the discussion on whether people have a right to die, or whether it was ok to use tissue from aborted fetuses for stem cell research or whether we need universal health care, has anyone ever asked, "Well, what do the philosophers think?" (I have nothing against philosophers, btw. I…

> At any point in the discussion on whether people have a right to die, or whether it was ok to use tissue from aborted fetuses for stem cell research or whether we need universal health care, has anyone ever asked, "Well, what do the philosophers think?" Yes, many people. In civilised countries that are not all about "pop culture" and where science is not supposed to be half about marketing stuff to people -- people…

> In civilised countries [...]

Name one.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#186

Earlier quoted context omitted.

The flip side to that argument is that right now life is short, and so I try and fit as many wonderful experiences into it as I can. If life were long I could put everything off until tomorrow. And that doesn't sound good to me.

I've thought about this once or twice before. I wonder how we would view life if we didn't die from aging or disease, but only accidents, like a fire, car crash, gun shot, etc. What would happen to religion? Do you choose to continue aging, die, and take your chances with the heaven you've been saying exists, or do you take the new pill, and live forever? If you take the pill, what does that say about your faith in t…

You can't live forever because the universe won't last forever. The earth will die out much sooner, of course.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#187

Earlier quoted context omitted.

Neither do you! So stop trying to predict that it's necessarily a bad or "selfish" thing.

Boom. This was a great rebuttal, I just needed to say that.

No one cares

Re: Anti-ageing compound set for human trials after turning clock back for mice

#189
post #94

Earlier quoted context omitted.

Cancer is a big treatment problem. Well here I am a tired old 95 year old cancer cell, too tired and sore to start reproducing madly and my hosts blood chemistry is too F'ed up anyway for me to grow, so I'll just sit here in my lung cell sized recliner and watch Fox News with my host... Ah I see now after some treatment I feel I'm in the body of a healthy 25 year old and I'm absolutely bursting with energy... lets ge…

Correct me if I'm wrong, but if this were an accurate metaphor, wouldn't cancer incidence decrease with age, rather than increase?

Cancer does decrease with age. I read it somewhere that it is some professor's pet theory but they do have some evidence.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#190
post #96
post #52

Earlier quoted context omitted.

This post fills me with questions. Foremost: What makes anti-aging technology unnatural compared to other medical treatments? To take one example, the smallpox vaccine was initially considered unnatural, and an affront to God[1]. [1] http://abob.libs.uga.edu/bobk/whitem10.html

Wouldn't this treatment system create an immense selection pressure against irrational belief? So kids born to families who think its an affront to god would not have the social / cultural / monetary resources to even begin to compete with kids born to more rational families? Not that I'm saying a selection pressure against irrational belief would be a negative or a problem, I'm just saying it would be strongly selec…

Only if people who take this anti-aging have more offspring. It's quite possible the opposite would be true.. "oh there is no rush, maybe next decade"
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