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Anti-ageing compound set for human trials after turning clock back for mice

theguardian.com

81–90 of 243 posts

Re: Anti-ageing compound set for human trials after turning clock back for mice

#83
post #80

Earlier quoted context omitted.

if they are successful (which I hope they are) then we're talking about pushing back retirement until 90 or maybe 95 right? Which I would be totally OK with. Imagine how much more scientific progress we could make if we had 70-year veterans of their field with the sharp mind of a 27-year-old!

Is that the goal of life? Incessant scientific progress?

For me? Yeah, pretty much.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#84
post #37

Researchers injected a chemical called nicotinamide adenine dinucleotide, or NAD, which reduces in the body as we age. The addition of this compound led to the radical reversal in the ageing of the mice. While this is pretty cool, it seems that the most immediate effect would be a higher availability of adenosine triphosphate (ATP), meaning more energy "currency" for the body's machinery to work with [1] [2] (someone…

One "philosophical question" which we already know the answer to, is at least in the short term and as a rare tool its not going to change much of anything. For example according to key metrics blah blah my grandmother's bypass surgery restored her circulation to that of a young woman blah blah but it hardly turned her into a sorority girl or whatever sociological blather. Ditto my grandfathers gallbladder removal.

To some extent an old dude with no medical conditions to complain about is just going to be an old dude with no medical conditions to complain about. You'll get to hear more Fox News talking points instead of medical symptoms.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#85
post #37

Researchers injected a chemical called nicotinamide adenine dinucleotide, or NAD, which reduces in the body as we age. The addition of this compound led to the radical reversal in the ageing of the mice. While this is pretty cool, it seems that the most immediate effect would be a higher availability of adenosine triphosphate (ATP), meaning more energy "currency" for the body's machinery to work with [1] [2] (someone…

“Personally, I’ve been hearing all my life about the Serious Philosophical Issues posed by life extension, and my attitude has always been that I’m willing to grapple with those issues for as many centuries as it takes.” -Patrick Hayden

It's funny, I have a friend who is a full-time professional philosopher (teaches at a university) and you would not believe the amount of earnest essay writing there was in the philosophy community about Miley Cyrus's performance at the VMAs (something I've not actually seen myself). All sorts of theories about Freud and Hegel and this and that. Look Philos, I said to him, she got up on stage and did a little dance and that's really all there was to it.

The moral of this story is, serious philosophical issues have absolutely no bearing on real life. So full steam ahead says I! The longer we can prolong life, the greater leverage we can extract from experience, imagine being immersed in a subject for hundreds of years, what could you not do in a minute what would take someone with even decades of experience, years?

Re: Anti-ageing compound set for human trials after turning clock back for mice

#86
post #58
post #22

Earlier quoted context omitted.

Actually, before we started to "poop in the hole", the rates of infectious diseases were way lower.

What are you talking about? (serious question)

The era between the end of nomadic lifestyle but before civil engineering of water and sewer systems aka the centuries where the average woman had 14 kids and watched 12 of them die before adulthood. It kinda sucked.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#87
post #21

> "with scientists set to look at how the theory of age reversal can be used to treat diseases such as cancer, dementia and diabetes." Alzheimer's medications can generally improve cognition. Age-reversal medications might work even better if used at an early age. I always see articles, media, and papers focusing on how something new can be used to treat some existing disease. But what I'm always thinking is "can I u…

> It's a strange disconnect. I know everyone is thinking what I'm thinking, but you never see this in the articles. Is it some kind of taboo? Sure. It's ridiculously selfish. As you age, you realize your success in all things eventually boils down to experience and ability to execute. Ability to execute wanes with age, as experience is accumulated, so it balances out. Now imagine a spry 20 year old with 60 years of e…

Employment, the economy, and success are not zero-sum. Someone getting a job doesn't mean someone loses a job. Someone succeeding doesn't mean someone else is failing.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#88
post #60
post #21

Earlier quoted context omitted.

> It's a strange disconnect. I know everyone is thinking what I'm thinking, but you never see this in the articles. Is it some kind of taboo? Sure. It's ridiculously selfish. As you age, you realize your success in all things eventually boils down to experience and ability to execute. Ability to execute wanes with age, as experience is accumulated, so it balances out. Now imagine a spry 20 year old with 60 years of e…

This is a good opportunity to apply the "reversal test": you say the status quo is better than an envisaged alternative, so let's see how it looks if that alternative is the status quo and someone proposes to switch to what we have now. So: Imagine a world in which people (let's say) stay at 25-year-old health until the age of about 90, and then die quickly. And suppose, in this world, that someone comes along and sa…

We already have that substance its called HFCS. That and ethanol.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#89
post #65
post #60

Earlier quoted context omitted.

This is a good opportunity to apply the "reversal test": you say the status quo is better than an envisaged alternative, so let's see how it looks if that alternative is the status quo and someone proposes to switch to what we have now. So: Imagine a world in which people (let's say) stay at 25-year-old health until the age of about 90, and then die quickly. And suppose, in this world, that someone comes along and sa…

This is silly. You have absolutely no clue what a future with a "25-year-old health until the age of about 90" would look like. Not even close. There are literally millions of things, from the economy to social structure, that would be impacted. It's not possible to even remotely predict.

Neither do you! So stop trying to predict that it's necessarily a bad or "selfish" thing.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#90
post #22
post #13

Earlier quoted context omitted.

Yes. http://dresdencodak.com/2009/09/22/caveman-science-fiction/

Actually, before we started to "poop in the hole", the rates of infectious diseases were way lower.

Wait, what? Pooping in a (deep) hole, as opposed to, say, against a tree, is extremely good for people. Especially people who don't wear shoes.

Ref: http://endtheneglect.org/2012/01/how-the-outhouse-helped-sav...

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