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Anti-ageing compound set for human trials after turning clock back for mice

theguardian.com

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Re: Anti-ageing compound set for human trials after turning clock back for mice

#41

Post by ganeumann »

kps wrote: post #27
ChuckMcM wrote: post #4

I always wonder about this quote, “Whether that means we’ll all live to 150, I don’t know, but the important part is that we don’t spend the last 20 to 30 years of our lives in bad health.” Imagine a process that makes you feel like you are 25 right up until you body gives up at a physical age of 100 or something. Do you end up doing riskier things because you don't "feel" old? And if you did would you die sooner? It…

Personally, I probably do riskier things when I do feel old. Tick... tick... tick....

It's not the feeling old, it's the realization that you have, in fact, spent the first half of your life not doing the things you wanted to do. And then the realization that you better get a move on if you want to get them done.

Motorcycles, Porsches, divorce + remarriage to a much younger woman, angel investing. You know, the mid-life crisis.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#42

Post by criley2 »

maratd wrote: post #21
fragsworth wrote: post #8

> "with scientists set to look at how the theory of age reversal can be used to treat diseases such as cancer, dementia and diabetes." Alzheimer's medications can generally improve cognition. Age-reversal medications might work even better if used at an early age. I always see articles, media, and papers focusing on how something new can be used to treat some existing disease. But what I'm always thinking is "can I u…

> It's a strange disconnect. I know everyone is thinking what I'm thinking, but you never see this in the articles. Is it some kind of taboo? Sure. It's ridiculously selfish. As you age, you realize your success in all things eventually boils down to experience and ability to execute. Ability to execute wanes with age, as experience is accumulated, so it balances out. Now imagine a spry 20 year old with 60 years of e…

It's perfectly fair for the 20 year old, because they won't compete. It's not fair to the 50 or 60 year old, who has to compete with someone who has equal experience but is younger.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#43

Post by _random_ »

pvnick wrote: post #37

Researchers injected a chemical called nicotinamide adenine dinucleotide, or NAD, which reduces in the body as we age. The addition of this compound led to the radical reversal in the ageing of the mice. While this is pretty cool, it seems that the most immediate effect would be a higher availability of adenosine triphosphate (ATP), meaning more energy "currency" for the body's machinery to work with [1] [2] (someone…

Ageing is a genetic disease. It has to be cured. We evolved to adapt to specific environment. Now that we are changing this environment we must change ourselves as well. Everyone should be given an option to die but it should be just one of a few options.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#44

Post by KVFinn »

From Aubrey De Grey:

Short answer is it’s not all that big a deal in biomedical terms. It’s a great discovery in terms of understanding mitochondria, and it provides a new way to rejuvenate mito function, but it doesn’t tell us that rejuvenating mito function in isolation in an otherwise still-old animal is a good idea -- and there have for many years been other ways to rejuvenate mito function which have not led to longer lifespan in rodents, notably acetyl-L-carnitine combined with alpha-lipoic acid (which has been marketed as Juvenon).

Re: Anti-ageing compound set for human trials after turning clock back for mice

#45

Post by _random_ »

olalonde wrote: post #16
fragsworth wrote: post #8

> "with scientists set to look at how the theory of age reversal can be used to treat diseases such as cancer, dementia and diabetes." Alzheimer's medications can generally improve cognition. Age-reversal medications might work even better if used at an early age. I always see articles, media, and papers focusing on how something new can be used to treat some existing disease. But what I'm always thinking is "can I u…

The same is true of artificial intelligence. For example, articles always mention that brain simulation would help us understand brain diseases (alzheimer, schizophrenia, etc.) better and barely mention the much bigger implications of strong AI (like that it might be the last thing humans ever need to invent).

Maybe most people are not capable of understanding the possibilities of a strong AI? It's not like we will just have a nice sounding personal assistant.

Re: Anti-ageing compound set for human trials after turning clock back for mice

#46

Post by Mizza »

KVFinn wrote: post #44

From Aubrey De Grey: Short answer is it’s not all that big a deal in biomedical terms. It’s a great discovery in terms of understanding mitochondria, and it provides a new way to rejuvenate mito function, but it doesn’t tell us that rejuvenating mito function in isolation in an otherwise still-old animal is a good idea -- and there have for many years been other ways to rejuvenate mito function which have not led to…

Where are you getting this from?

Re: Anti-ageing compound set for human trials after turning clock back for mice

#47

Post by indrax »

ams6110 wrote: post #17
salient wrote: post #12

Earlier quoted context omitted.

I'd rather have the choice. I have no choice with ageing. The same is true of "immortality". What immortality really means is that you kind of have a choice of not disappearing forever (well unless a car runs you down or something, but in the future that can probably be fixed, too, by "backing ourselves up").

Rather selfish? We'll have enough problems in the coming decades with geriatric baby boomers, you now want to give people the option to live forever?

You want to let everyone die to maintain solvency?

Re: Anti-ageing compound set for human trials after turning clock back for mice

#48

Post by [deleted] »

pvnick wrote: post #37

Researchers injected a chemical called nicotinamide adenine dinucleotide, or NAD, which reduces in the body as we age. The addition of this compound led to the radical reversal in the ageing of the mice. While this is pretty cool, it seems that the most immediate effect would be a higher availability of adenosine triphosphate (ATP), meaning more energy "currency" for the body's machinery to work with [1] [2] (someone…

[deleted]

Re: Anti-ageing compound set for human trials after turning clock back for mice

#49

Post by rtfeldman »

pvnick wrote: post #37

Researchers injected a chemical called nicotinamide adenine dinucleotide, or NAD, which reduces in the body as we age. The addition of this compound led to the radical reversal in the ageing of the mice. While this is pretty cool, it seems that the most immediate effect would be a higher availability of adenosine triphosphate (ATP), meaning more energy "currency" for the body's machinery to work with [1] [2] (someone…

Anti-aging has nothing more to do with immortality than does, say, curing a particular disease.

Aging is only one of many causes of death; if we solve that one, there's still heart disease, stroke, getting hit by a bus...

Re: Anti-ageing compound set for human trials after turning clock back for mice

#50

Post by _random_ »

maratd wrote: post #21
fragsworth wrote: post #8

> "with scientists set to look at how the theory of age reversal can be used to treat diseases such as cancer, dementia and diabetes." Alzheimer's medications can generally improve cognition. Age-reversal medications might work even better if used at an early age. I always see articles, media, and papers focusing on how something new can be used to treat some existing disease. But what I'm always thinking is "can I u…

> It's a strange disconnect. I know everyone is thinking what I'm thinking, but you never see this in the articles. Is it some kind of taboo? Sure. It's ridiculously selfish. As you age, you realize your success in all things eventually boils down to experience and ability to execute. Ability to execute wanes with age, as experience is accumulated, so it balances out. Now imagine a spry 20 year old with 60 years of e…

Your thought process is linear. Try to model the consequences. 20 yeas old people will be considered kids and that's it. Otherwise you should opt for euthanasia because 10 year olds have a hard time competing with you today.
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