Lisp will never be popular. Everyone likes to kiss the ass of Lisp, and talk about how transformative and powerful it is, then they go and write a bunch of Python or Ruby or Lua or Perl or anything other than Lisp, because infix is just much much more readable. When was the last time you went to a math class and the professor wasn't using infix notation? Even the Common Lisp Hyperspec has to resort to infix notation…
So the question now is, are those of us who have no problem with prefix notation merely a random minority of the population, like people who are left-handed, or are we a minority like say the minority who are good at math, or the minority who used the Internet in 1995?
I'm not saying for sure we are. Even after all these years, I still can't say for sure whether ordinary programmers will ever be able to deal with prefix notation. But I also don't feel it's safe to dismiss the possibility.