Ultimately the common thread in most of these cases seems to be a lack of purpose and meaning in life in general, not really an issue with the specific work environment. The purpose of life is to make meaningful human connections, become wiser, become a better person. This is something that some combination of family, traditional social structures and religion used to provide for a lot of people. "Create shareholder…
Some are lucky enough to get meaning from the default path of those around them, some have trouble finding a way that works for them.
Every person should consider what their own purpose is (and why, and what “purpose” even means for them) or they will be held in thrall to the social forces around them. If they don’t fundamentally align with those forces, they will have a bad time, and they may blame themselves rather than recognizing that they should seek a different path.